COBRE: Eukaryotic Pathogens Innovation Center (EPIC)

COBRE：真核病原体创新中心（EPIC）

基本信息

批准号：
10666653
负责人：
JAMES Culvin MORRIS
金额：
$ 221.43万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-15 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10666653
关键词：
Advisory Committees African Trypanosomiasis Amebic colitis Antifungal Agents Antiparasitic Agents Area Aspergillosis Aspergillus fumigatus Assistantship Award Azoles Bioinformatics Biology Bioterrorism Cardiovascular Diseases Cell Separation Centers of Research Excellence Chagas Disease Classification Collaborations Colon Carcinoma Communicable Diseases Communication Complex Country Cryptococcus Detection Development Diagnosis Disease Dynein ATPase Dysentery Educational workshop Environment Environmental Risk Factor Equipment Evolution Faculty Faculty Recruitment Fostering Funding Fungal Meningitis Genomics Global Change Goals Grant Helminths Host Defense Human Image Incidence Infection Infrastructure Institution Interdisciplinary Study Knowledge Leadership Light Macrophage Malaria Medical Meningitis Mentors Modeling Musculoskeletal Diseases Oxidants Parasites Parasitic Diseases Phase Pilot Projects Postdoctoral Fellow Poverty Probability Program Research Project Grants Regulation Research Research Personnel Resource Allocation Role Scientist South Carolina Stress Stroke Student recruitment Toxoplasmosis Training Trichomonas Infections Trypanosoma United States National Institutes of Health Universities Vaccines Virulence Zebrafish base climate change college dietary supplements drug discovery emerging pathogen graduate student human disease imaging facilities innovation insight lipidomics member multidisciplinary neglect neglected tropical diseases pathogen primary amebic meningoencephalitis programs recruit response skills success targeted treatment tenure track tissue regeneration transmission process vector

项目摘要

PROJECT SUMMARY/ABSTRACT Eukaryotic pathogens are the causative agents of some of the most devastating and intractable diseases of humans, including malaria, amebic dysentery, African sleeping sickness, Chagas disease, trichomoniasis, aspergillosis, cryptococcal fungal meningitis, toxoplasmosis and primary amebic meningoencephalitis (PAM). The global impact of these diseases is immense. It is noteworthy that many of these pathogens are the causative agents of neglected tropical diseases (NTDs), neglected diseases of poverty (NDPs) and/or are classified as bioterrorism agents. Importantly, infections caused by eukaryotic pathogens are increasing in the US due to globalization. The primary goal of this COBRE proposal is to increase the number of NIH-funded scientists in the state of South Carolina by supporting a world-class research center, the Eukaryotic Pathogens Innovation Center (EPIC), at Clemson University (CU). The scientific focus of EPIC is a multidisciplinary study of important global eukaryotic pathogens. EPIC is the first-and-only in the state with a focus on infectious diseases, and the first- and-only in the country with a focus on eukaryotic pathogens. Four projects from target junior investigators will be supported. Their projects are 1) Regulation mechanisms of Trypanosome brucei axonemal dynein, 2) Functional roles of ncRNA, afu-182, in azole response and pathobiology of Aspergillus fumigatus, 3) Investigating the function of macrophages in the efficacy of anti-fungal drugs in larval zebrafish, and 4) Evaluating anti-parasitic diazacyclobutenes. These investigators will be matched with external and internal mentors who are established NIH-funded researchers. The projects will be supported by a well-organized Administrative Core and two state-of-the-art Scientific Cores in Genomics, and Imaging/Cell Sorting. The center also has a substantial infrastructure base and significant institutional support. For example, CU will recruit two additional faculty members and two post-doctoral fellows to expand activities of this center over the course of the project period. Pledges of graduate assistantships, equipment, and space further exemplify the institutional commitment. The continuation of this COBRE-funded center will significantly expand research in South Carolina and will facilitate recruitment, training, and retention of a critical mass of investigators with cross-disciplinary skills in this important research area.

项目概要/摘要真核病原体是一些最具破坏性和棘手疾病的病原体人类，包括疟疾、阿米巴痢疾、非洲昏睡病、恰加斯病、滴虫病、曲霉病、隐球菌真菌性脑膜炎、弓形虫病和原发性阿米巴脑膜脑炎 (PAM)。这些疾病的全球影响是巨大的。值得注意的是，许多这些病原体都是致病菌。被忽视的热带病 (NTD)、被忽视的贫困疾病 (NDP) 和/或被归类为生物恐怖主义代理人。重要的是，由于以下原因，美国由真核病原体引起的感染正在增加全球化。 COBRE 提案的主要目标是增加 NIH 资助的科学家数量南卡罗来纳州通过支持世界一流的研究中心真核病原体创新中心（EPIC），克莱姆森大学（CU）。 EPIC 的科学重点是对全球重要问题进行多学科研究真核病原体。 EPIC 是该州第一个也是唯一一个专注于传染病的机构，也是第一个- 并且-仅在专注于真核病原体的国家。目标初级研究人员的四个项目将得到支持。他们的项目是 1) 布氏锥虫轴丝动力蛋白的调节机制，2) ncRNA，afu-182，在烟曲霉的唑反应和病理学中的功能作用，3) 研究巨噬细胞在斑马鱼幼体抗真菌药物疗效中的功能，以及4)评估抗寄生虫二氮杂环丁烯。这些调查员将与外部和内部导师相匹配，他们是建立了 NIH 资助的研究人员。这些项目将得到组织良好的行政核心和基因组学和成像/细胞分选两个最先进的科学核心。该中心还拥有大量基础设施基础和重要的制度支持。例如，CU将额外招聘两名教师成员和两名博士后研究员，以在项目期间扩大该中心的活动。研究生助学金、设备和空间的承诺进一步体现了机构的承诺。这该 COBRE 资助的中心的延续将显着扩大南卡罗来纳州的研究范围，并将促进在这一重要领域招募、培训和留住足够数量具有跨学科技能的调查人员研究领域。