SEVERE ASTHMA RESEARCH PROGRAM

严重哮喘研究计划

• 批准号: 7718576
• 负责人: Benjamin Gaston
• 金额: $ 3.02万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718576
• 关键词: Ammonia; Asthma; Computer Retrieval of Information on Scientific Projects Database; Funding; Glutathione Disulfide; Goals; Grant; Hydrogen Peroxide; Institution; Nitric Oxide; Nitrogen Oxides; Oxidation-Reduction; Patients; Protocols documentation; Reduced Glutathione; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Universities; Virginia; cytotoxic; improved; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is part of the Severe Asthma Research Program (SARP) sponsored by the NHLBI. The goal of the program is to characterize the distinguishing features of severe asthma in order to improve management protocols. At the University of Virginia, the investigators will test the following three hypotheses: 1. Breath condensate pH, ammonia and reduced glutathione values are lower in patients with severe asthma than in patients with mild asthma and in controls. 2. Breath condensate hydrogen peroxide and oxidized glutathione concentrations are higher in patients with severe asthma than in patients with mild asthma and in controls. 3. Airway redox changes in severe asthma result in loss of cytoprotective nitrogen oxides and formation of cytotoxic nitrogen oxide.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该协议是 NHLBI 赞助的严重哮喘研究计划 (SARP) 的一部分。 该计划的目标是描述严重哮喘的显着特征，以改进治疗方案。 在弗吉尼亚大学，研究人员将测试以下三个假设： 1. 重度哮喘患者的呼吸冷凝液 pH、氨和还原型谷胱甘肽值低于轻度哮喘患者和对照组。 2. 重度哮喘患者的呼吸冷凝物过氧化氢和氧化型谷胱甘肽浓度高于轻度哮喘患者和对照组。 3.严重哮喘中气道氧化还原的变化导致细胞保护性氮氧化物的丧失和细胞毒性氮氧化物的形成。