MAGNETIC FIELD THERAPY IN DIABETIC PERIPHERAL NEUROPATHY

糖尿病周围神经病的磁场治疗

• 批准号: 7718522
• 负责人: A. Gordon Smith
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718522
• 关键词: Affect; Amputation; Calcium Channel; Computer Retrieval of Information on Scientific Projects Database; Daily; Diabetes Mellitus; Diabetic Neuropathies; Electromagnetic Fields; Fire - disasters; Frequencies; Funding; Grant; Hour; Institution; Nerve; Nerve Fibers; Nerve Regeneration; Nicotinamide adenine dinucleotide; Pain; Patients; Peripheral Nervous System Diseases; Physiologic pulse; Pulse taking; Quality of life; Refractory; Research; Research Personnel; Resources; Risk; Score; Sensory; Sodium; Source; Time; United States National Institutes of Health; diabetic; disability; foot; foot sole; improved; magnetic field; magnetic therapy; painful neuropathy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diabetic neuropathy (DPN) affects 50% of patients with diabetes, resulting in degeneration of the longest nerves, resulting in sensory loss, pain and weakness. Pain and risk for foot amputation are the most common associated disabilities. Pain in DPN results from abnormal firing of small nerve fibers with accumulation of sodium and calcium channels. Pulsed magnetic fields induce extremely low-frequency (ELF) currents, which cause nerves to become refractory to further firing. We hypothesize that directing a magnetic field into the soles of the feet may reduce abnormal nerve firing responsible for DPN pain. Objectives: To determine if two hours of daily Pulsed Electromagnetic Field Therapy (PEMF) in subjects with painful DPN over a three-month period of time can: 1. Reduce neuropathic pain scores 2. Improve quality of life 3. Result in nerve regeneration.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 糖尿病神经病（DPN）影响50％的糖尿病患者，导致最长的神经退化，导致感觉丧失，疼痛和无力。脚截肢的疼痛和风险是最常见的相关残疾。 DPN的疼痛是由于钠和钙通道积累的小神经纤维的异常发射引起的。 脉冲磁场会诱导极低的频率（ELF）电流，这会导致神经变得难治性，从而进一步发射。 我们假设将磁场引导到脚底上可能会减少导致DPN疼痛的神经发射异常。 目的：确定在三个月内患有DPN疼痛的受试者的每日脉冲电磁场​​治疗（PEMF）是否可以： 1。降低神经性疼痛评分 2。提高生活质量 3。导致神经再生。