CHRONIC LUNG DISEASE IN VERY LOW BIRTH WEIGHT INFANTS

极低出生体重婴儿的慢性肺病

• 批准号: 7718488
• 负责人: CHRISTIAN CON YOST
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718488
• 关键词: Birth; Blood; Chronic lung disease; Computer Retrieval of Information on Scientific Projects Database; DNA; Development; Enrollment; Funding; Genes; Genetic Polymorphism; Genotype; Grant; Infant; Informed Consent; Institution; Life; Measurement; Mechanical ventilation; Observational Study; Platelet Activating Factor; Research; Research Personnel; Resources; Serum; Source; United States National Institutes of Health; Very Low Birth Weight Infant; day; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a prospective observational study to determine whether there is an association between the presence of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms and the development of chronic lung disease in very low birth wight infants. Infants 1500 grams at birth who require mechanical ventilation will be enrolled in the first 5 days of life after obtaining informed consent. A total of 1 ml of blood will be drawn and utilized for isolation of DNA for genotyping and for measurement of PAF-AH activity in serum.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这是一项前瞻性观察性研究，旨在确定血小板激活因子乙酰水合酶（PAF-AH）基因多态性之间是否存在关联与非常低的出生生育婴儿中慢性肺部疾病的发展。需要机械通气的婴儿在出生时1500克，将在获得知情同意后的前5天内入学。总共将抽取1 mL的血液，并用于分离DNA，以用于基因分型和测量血清中的PAF-AH活性。