ROLE OF TETRAHYDROBIOPTERIN DEFICIENCY IN CARDIOVASCULAR FUNCTION WITH AGING

四氢生物蝶呤缺乏对衰老过程中心血管功能的作用

• 批准号: 7719547
• 负责人: Gary L. Pierce
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719547
• 关键词: Adult; Affect; Aging; Animals; Biological Availability; Cardiovascular Physiology; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Elderly; Exercise; Funding; Grant; Human; Institution; Lead; Measures; Nitric Oxide; Oxidative Stress; Production; Relative (related person); Research; Research Personnel; Resources; Role; Source; Stress; Training; United States National Institutes of Health; Vasodilation; age related; human data; sedentary; tetrahydrobiopterin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The age-related decrease in nitric oxide availability constitutes one of the mechanisms by which advancing age adversely affects the cardiovascular function (i.e. endothelial dependent vasodilation and arterial compliance) in humans. There are several potential mechanisms by which nitric oxide production may be reduced with aging. However, current animal and human data sugesst that increased oxidative stress may lead to an absolute and/or relative decrease in BH4, leading to a subsequent decrease in nitric oxide bioavailability. Because advancing age is associated with increased oxidative stress level, it is resonable to hypothesis that the age related changes in cardiovascular function may be, at least in part, due to a decrease in BH4 bioactivity. In contrast, endurance exercise training is associated with a more favorable cardiovascular function and decreased oxydative stress level. Therefore, it is also resonable to hypothesize that the more favorable cardiovascular profile associated with regular exercise may be, at least in part, due to a greater BH4 bioavailability. Consequently, the specific aim of this study is to measure the caridovascular function before and after administering BH4 in young and older sedentary adults and in endurance exercise-trained older adults.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 一氧化氮可用性与年龄相关的降低构成了一种机制之一，即促进年龄对人类的心血管功能（即内皮依赖的血管舒张和动脉依从性）的机制之一。有几种潜在的机制可以随着衰老而减少一氧化氮的产生。但是，当前增加氧化应激的动物和人类数据可能导致BH4的绝对和/或相对降低，从而导致一氧化氮生物利用度的随后降低。由于增长年龄与氧化应激水平升高有关，因此可以使假设与年龄相关的心血管功能的变化至少部分是由于BH4生物活性的降低。 相比之下，耐力运动训练与更有利的心血管功能和氧应力水平降低有关。因此，假设与定期运动相关的更有利的心血管剖面可能至少部分是由于BH4生物利用度较高，这也可以引起共鸣。因此，这项研究的具体目的是测量在年轻和年长的久坐成年人以及接受耐力运动训练的老年人中给药之前和之后的颈椎功能。