Clemson University Genomics and Bioinformatics Facility (CUGBF)

克莱姆森大学基因组学和生物信息学设施 (CUGBF)

• 批准号: 10666659
• 负责人: CHRISTOPHER L PARKINSON
• 金额: $ 48.48万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666659
• 关键词: Applications Grants; Architecture; Award; Bioinformatics; Biological Sciences; Biology; Centers of Research Excellence; Communities; Computational Biology; Computers; Data; Data Analyses; Data Files; Data Science; Development; Education; Education and Outreach; Educational workshop; Epigenetic Process; Equipment; Event; Faculty; Funding; Generations; Genes; Genetic; Genomic medicine; Genomics; Goals; Health; High Performance Computing; Human Genetics; Human Resources; Information Sciences; Infrastructure; Institution; Investments; Laboratories; Magnetic Resonance Imaging; Measures; Memory; Mission; Modeling; Molecular; Nucleic acid sequencing; Performance; Phase; Pilot Projects; Postdoctoral Fellow; Process; Publications; Pythons; Research; Research Personnel; Resources; Reverse Transcriptase Polymerase Chain Reaction; Science; Secure; Services; South Carolina; Specialist; Strategic Planning; Structure; Students; Supercomputing; Supervision; System; Teacher Professional Development; Technology; Therapeutic Intervention; Training; United States National Institutes of Health; Universities; Variant; bioinformatics infrastructure; bioinformatics tool; college; complex data; computer infrastructure; computing resources; design; doctoral student; empowerment; equipment acquisition; expectation; faculty research; genome resource; genome sciences; genome sequencing; genomic tools; graduate student; human capital; improved; innovation; insight; member; next generation; next generation sequencing; pathogen; peer; precision medicine; programs; therapeutic development; therapy development; tool; training opportunity; transcriptome sequencing

Project Summary/Abstract Genomics and bioinformatics are the currency in today’s Life Science research. A major obstacle for junior faculty from IDeA states is the lack of state-of-the-art facilities and training opportunities commonly found in states with substantial NIH funding. This often hinders the generation of preliminary data necessary to be competitive for NIH R01 funding. The implementation of advanced tools to measure and interpret gene dynamics and genomic architecture is vital to the study of eukaryotic pathogens for the development of therapeutic intervention. Genomic level analyses and bioinformatics are a developing field, with rapidly emerging new standards and technologies that provide insight into the fundamentals of eukaryotic biology. Most life science researchers are not experienced in the use of bioinformatics and genomics. Therefore, we propose the continuation of the bioinformatics specialists hired under COBRE Phase I, hire an additional wet lab technician to handle our rapidly increasing load and then bolster the genomics, computational and bioinformatic infrastructure and educational outreach via the Clemson University Genomics and Bioinformatics Facility (CUGBF) throughout Phase II. The enhanced CUGBF is structured into three complementary parts: 1) a molecular laboratory with genomics and next-generation sequencing (NGS) resources, 2) a bioinformatics laboratory with high performance computing resources, & 3) the personnel and equipment at the Clemson University Center for Human Genetics- Genomics Sciences laboratory (CUCHG-GSL which is supported by a COBRE in Human Genetics). Having all three allows the enhanced CUGBF to offer a comprehensive service package from extraction and next-generation sequencing of nucleic acid to the complex data analysis and interpretation. Through this model, CUGBF has designed, executed, and educated EPIC TIs and CU faculty to enable the integration of genomics and bioinformatics into their research programs. The Primary goal of this COBRE Phase II core enhancement proposal is to continue to enhance the current physical and human capital for genomics and computational infrastructure of the CUGBF and integrate genomic data and computational resources into the TI’s and CU faculty research programs.

项目概要/摘要 基因组学和生物信息学是当今生命科学研究的一个主要障碍。 对于来自 IDeA 州的初级教师来说，缺乏最先进的设施和培训机会 常见于拥有大量 NIH 资金的州，这通常会阻碍生成。 获得 NIH R01 资助所需的初步数据 实施。 测量和解释基因动态和基因组结构的先进工具对于 研究真核病原体以开发基因组水平的治疗干预。 分析和生物信息学是一个发展中的领域，新标准和技术迅速出现 提供对大多数生命科学基础知识的深入了解的技术。 研究人员在使用生物信息学和基因组学方面没有经验。 建议继续聘用 COBRE 第一阶段的生物信息学专家， 额外的湿实验室技术人员来处理我们快速增加的负载，然后支持基因组学， 通过克莱姆森大学的计算和生物信息基础设施以及教育推广 大学基因组学和生物信息学设施 (CUGBF) 贯穿第二阶段。 CGBF 由三个互补的部分组成：1) 基因组学分子实验室 和下一代测序（NGS）资源，2）具有高水平的生物信息学实验室 性能计算资源，以及3）克莱姆森大学的人员和设备 人类遗传学中心-基因组科学实验室（CUCHG-GSL，由 人类遗传学中的 COBRE）。拥有这三者使得增强的 CGBF 能够提供 从核酸提取到新一代测序的综合服务包 通过这个模型，CUGBF 设计了， 执行和教育 EPIC TI 和 CU 教师，以实现基因组学和 COBRE II 期核心的主要目标。 增强建议是继续增强现有的物质和人力资本 CGBF 的基因组学和计算基础设施，并整合基因组数据和 TI 和 CU 教师研究项目的计算资源。