Bioadhesive Membrane Constructs to Augment Tendon Repair

生物粘附膜结构增强肌腱修复

• 批准号: 7669485
• 负责人: Bruce P Lee
• 金额: $ 13.41万
• 依托单位: NERITES CORPORATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7669485
• 关键词: Adhesions; Adhesives; Allografting; Amino Acids; Animal Model; Area; Binding; Biological; Biomechanics; Biomimetics; Breathing; Catechols; Collagen Fiber; Communities; Dermal; Dermis; Development; Devices; Dopa; Drug Formulations; Early Mobilizations; Environment; Evaluation; Exhibits; Family suidae; Fiber; Frequencies; Government; Human; Immobilization; In Vitro; Incidence; Injury; Marines; Mechanics; Medical; Membrane; Meniscus structure of joint; Metals; Methods; Modeling; Mussels; Natural regeneration; Orthopedics; Oxidants; Patients; Persons; Phase I Clinical Trials; Phase II Clinical Trials; Polymers; Postoperative Pain; Postoperative Period; Prevalence; Property; Proteins; Recovery; Rehabilitation therapy; Research; Resistance; Rotator Cuff; Safety; Saline; Secure; Site; Small Intestinal Submucosa; Specific qualifier value; Sterilization for infection control; Surface; Surgical complication; Surgical sutures; Techniques; Tendon Injuries; Tendon structure; Testing; Time; Tissues; Transplanted tissue; Water; Wound Healing; achilles tendon; adhesive polymer; aging population; biomaterial compatibility; bone; crosslink; improved; in vivo; injured; injury and repair; interest; new technology; novel; public health relevance; repaired; sample fixation; scaffold; success

DESCRIPTION (provided by applicant): The frequency with which tendon injuries are occurring is increasing due to medical advances that allow an increasingly aging population to remain physically active longer than previously possible. There is a great deal of controversy among the orthopedic community regarding the best and most effective method of treating such injuries. While progress has been made in improving the method of fixation of torn tendons, there remains a need to further enhance the currently employed methods to allow for earlier rehabilitation and fewer incidences of post-operative pain, surgical complications, and rerupture of the repaired tissues. Conventional methods of augmentation secure the injured tissue and/or graft at only a few points via suture, thus placing a great strain at the suture sites. By better securing the graft to the repair, and dispersing the tension over the entire graft surface, the patient can potentially begin post-operative rehabilitation much sooner. Early mobilization has been found to be critical in regenerating well-organized and functional (fibers in) tendons. Marine mussels provided the inspiration for the new technology presented in this proposal. By releasing rapidly hardening, tightly binding adhesive proteins, marine mussels have the ability to anchor themselves to various surfaces in a wet, turbulent, and saline environment. Both natural proteins and their synthetic mimics have been shown to bind strongly to various substrates ranging from biological tissues to metal surfaces. In this proposal, biomimetic synthetic adhesives will be combined with a natural scaffold to create a novel bioadhesive membrane. The intent of such a construct is to create a repair that is stronger than sutures alone by securing the material over the entire surface area being repaired. The feasibility of using such a material as an augmentation device for tendon repair will be tested. PUBLIC HEALTH RELEVANCE: Injuries of tendons have been occurring with increasing prevalence over the last several decades. Current fixation methods and materials have exhibited mixed success, but each has limitations. The development and evaluation of a novel bioadhesive membrane construct to augment tendon repair is described here.

描述（由申请人提供）：由于医疗进展，肌腱损伤发生的频率正在增加，这使得越来越老化的人群的身体活跃时间比以前可能更长。关于治疗此类伤害的最佳和最有效方法，骨科界之间存在很大的争议。尽管在改善肌腱骨肌腱的固定方法方面取得了进展，但仍需要进一步增强当前使用的方法，以允许较早的康复和术后疼痛，手术并发症以及修复组织的重新爆发的发生率。 传统的增强方法仅通过缝合线将受伤的组织和/或移植物固定在几个点上，从而在缝合部位放置了很大的应变。通过更好地将移植物固定到维修中，并将张力分散在整个移植物表面上，患者可能会更快地开始术后康复。已经发现早期动员对于再生良好的肌腱和功能性（纤维）至关重要。 海洋贻贝为本提案中提出的新技术提供了灵感。通过释放快速硬化，紧密结合的粘合剂蛋白，海洋贻贝可以在潮湿，湍流和盐水环境中锚定在各种表面上。天然蛋白质及其合成模拟物均已证明与从生物组织到金属表面的各种底物强烈结合。在此提案中，仿生合成粘合剂将与天然脚手架结合使用，以产生一种新型的生物粘附膜。这种结构的目的是通过在整个表面积上固定材料来创建比单独缝合的维修。将测试使用这样的材料作为肌腱修复的增强装置的可行性。 公共卫生相关性：在过去的几十年中，肌腱的伤害一直在发生。当前的固定方法和材料表现出不同的成功，但每种都有局限性。这里描述了一种新型生物粘附膜结构增强肌腱修复的开发和评估。