PARTIAL AND COMPLETE GROWTH HORMONE BLOCKADE IN POLYCYSTIC OVARY SYNDROME

多囊卵巢综合征的部分和完全生长激素阻断

• 批准号: 7716885
• 负责人: JULIE LUND SHARPLESS
• 金额: $ 0.38万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716885
• 关键词: Affect; Age; Complex; Computer Retrieval of Information on Scientific Projects Database; Disease; Functional disorder; Funding; Goals; Grant; Heart Diseases; Hormone Antagonists; Hyperandrogenism; Infertility; Institution; Insulin Resistance; Insulin-Like Growth Factor I; Physiological; Polycystic Ovary Syndrome; Research; Research Personnel; Resources; Somatotropin; Source; Syndrome; United States National Institutes of Health; Woman; diabetes risk; improved; new growth; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The poorly understood syndrome of Polycystic Ovary Syndrome (PCOS) affects 5-8% of reproductive age women and results in infertility as well as an increased risk of diabetes and heart disease. The long term objective of this proposal is to improve understanding of the pathophysiology of PCOS in order that more effective treatments can be developed. This proposal uses a new growth hormone antagonist as a physiological probe to isolate the effects of growth hormone in this complex and poorly understood disease. The short term goal of this proposal is to determine the contribution of growth hormone and IGF-1 to the excess insulin resistance and hyperandrogenism in PCOS.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 多囊卵巢综合征（PCOS）的综合征鲜为人知的综合征影响了5-8％的生殖年龄妇女，导致不孕症以及糖尿病和心脏病的风险增加。该建议的长期目标是提高对PCOS病理生理学的理解，以便可以开发出更有效的治疗方法。 该提案使用一种新的生长激素拮抗剂作为生理探针，以分离生长激素在这种复杂且知识熟悉的疾病中的影响。该提案的短期目标是确定生长激素和IGF-1对PCOS中过量胰岛素抵抗和超雄激素的贡献。