BRAIN CHANGES AND RISK FACTORS

大脑变化和危险因素

• 批准号: 7719125
• 负责人: Leslie Wolfson
• 金额: $ 1.23万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719125
• 关键词: Anatomy; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Cross-Sectional Studies; Diffusion Magnetic Resonance Imaging; Disease; Elderly; Funding; Grant; Image; Impairment; Institution; Lesion; Link; Location; Magnetic Resonance Imaging; Measures; Numbers; Parietal; Pathway interactions; Predictive Value; Process; Quality of life; Rate; Research; Research Personnel; Resources; Risk; Risk Factors; Scanning; Signal Transduction; Site; Source; Students; United States National Institutes of Health; Vascular Diseases; disorder risk; follow-up; ischemic lesion; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mobility is a critical component of independence and the quality of life of older persons. A significant number of older persons with mobility impairment demonstrate ischemic lesions in brain white matter (WM). We hypothesize that: Students with a high level of vascular disease risk factors, will have a larger initial volume and higher accrual rate of white matter signal abnormality (WMSA); impaired mobility is caused by site-specific WMSA damaging fronto-parietal periventricular WM and WMSA accrual rate is stable allowing predication of Ss at risk" for large WMSA increases. The link between ischemic WM lesions, which appear on MRI as WM signal abnormality (WMSA), and vascular disease risk factors (VDRF), as a cause, requires better definition. We propose to link VDRF to mobility impairment associated with WMSA and then determine if the risk factors predict incident cases. This will allow us to assess the magnitude of the VDRF as a cause of mobility impairment in order to plan new treatment strategies. We will use quantitative Magnetic Resonance Imaging (MRI) and quantitative measures of mobility to link WMSA to mobility disorders. In preliminary studies, we separated older persons into groups with normal and impaired mobility. Automated quantitative segmentation of the MR images showed an accrual of WMSA is related to a disease process. Site-specific periventricular WMSA involving frontal and parieto-occipital regions were present in Students with impaired mobility. Follow-up MRIs on 14 Students, 20 months after the initial scan, showed WMSA accrual was related to WMSA volume at baseline suggesting a continuous process and that the volume of WMSA increased at a five-fold greater rate in mobility impaired compared to normal Students. We have recently determined that the quantitative measures of mobility are reliable. To move beyond correlation, we are proposing a 5-year project with 2 components: a cross-sectional analysis of 99 Students 70 years and older stratified by mobility, followed by a 4 year longitudinal follow-up. The cross-sectional component will determine the relationship of VDRF, WMSA volume, WMSA location, use diffusion tensor imaging to identify/quantify damage to WM pathways and quantitative measures of mobility. Using the same measures, the longitudinal component will: 1) establish the link between VDRF and mobility impairment; 2) establish clinical predictive value of imaging; 3) evaluate the causal relationship of WMSA to mobility; 4) refine our understanding of the anatomic substrate of mobility impairment; and 5) define the progression of this disorder.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 流动性是独立性和老年人生活质量的关键组成部分。 大量迁移障碍的老年人表明，脑白质（WM）中的缺血性病变。 我们假设这一点：具有高水平血管疾病危险因素的学生将具有较大的初始体积和更高的白质信号异常（WMSA）的应计率；受损的活动能力是由特定地点特异性的WMSA损坏额室周围WM和WMSA应计率稳定的，允许SS处于危险中的预测”，大大的WMSA增加。缺血性WM病变之间的联系，在MRI上作为WM信号异常（WMSA）和VCARINE疾病的链接出现在MRI上，以及VCarborIation Wistional the Wistions wistive Wistions（vscartar）疾病（vscartar Isfiely）（vscartar Isfiles）（vrff）（vrff）（a）（a）（vsculin wist）（vrfff）（a）（a）与WMSA相关的VDRF对移动性障碍，然后确定风险因素是否预测事件案件。 我们将使用定量磁共振成像（MRI）和迁移率的定量度量将WMSA与迁移率障碍联系起来。 在初步研究中，我们将老年人分为正常和流动性受损的群体。 MR图像的自动定量分割显示，WMSA的应计与疾病过程有关。 特定地点的室室周围WMSA涉及额叶和枕骨枕骨区域的学生存在受损的学生。 初次扫描后20个月的14名学生的随访MRIS显示，WMSA应计与基线时的WMSA量有关，这表明连续过程，与正常学生相比，WMSA的数量以损害的5倍速度增加了五倍。 我们最近确定了迁移率的定量度量是可靠的。 为了超越相关性，我们提出了一个为期5年的项目，其中有2个组成部分：对70岁及以上的99名学生通过移动性分层的横断面分析，然后进行4年的纵向随访。 横截面组件将确定VDRF，WMSA体积，WMSA位置，使用扩散张量成像的关系，以识别/量化WM途径的损害和迁移率的定量测量。 使用相同的措施，纵向部分将：1）建立VDRF与移动性障碍之间的联系； 2）建立成像的临床预测价值； 3）评估WMSA与移动性的因果关系； 4）完善我们对移动性障碍的解剖基质的理解； 5）定义这种疾病的进展。