Data and Analytical Core

数据和分析核心

• 批准号: 10633812
• 负责人: Zhe Sage Chen
• 金额: $ 34.7万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-03 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10633812
• 关键词: Animals; Attention; Behavioral; Brain; Brain Diseases; Brain region; Cognition; Cognitive; Collaborations; Communication; Communities; Complex; Computer Models; Computer software; Data; Data Analyses; Data Analytics; Data Set; Decision Making; Dedications; Documentation; Electrophysiology (science); Functional Magnetic Resonance Imaging; Glues; Human; Image; Individual; Lead; Link; Machine Learning; Methods; Modeling; Monkeys; Multivariate Analysis; National Institute of Mental Health; Neurons; Neurosciences; Play; Population; Postdoctoral Fellow; Primates; Process; Publications; Pulvinar structure; Pythons; Recording of previous events; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Rodent; Role; Source; Structure; Techniques; Testing; Thalamic Nuclei; Thalamic structure; Travel; Tupaiidae; analytical tool; attentional control; cognitive control; data archive; data curation; data format; data pipeline; data sharing; executive function; high standard; human imaging; human-in-the-loop; innovation; machine learning method; meetings; multimodal data; multimodality; neural; neuroimaging; neuroregulation; statistical and machine learning; statistics; theories; tool; tool development; virtual; web site

The thalamus plays a critical role in attention, cognitive control and decision-making, serving as an important hub of temporal integration and coordination across nodes of large-scale cortical and subcortical networks. Identification of functional connectivity between thalamocortical networks across tasks and species is key to understanding complex thalamic computation at both single-unit and population levels. The Data and Analytic Core of the Conte Center project will contribute to attaining the Center objectives in multiple directions. We will establish a data curation/sharing pipeline and develop advanced statistical and data-driven machine learning tools for analyses of various sources of neural recordings from higher-order thalamic nuclei (especially the mediodorsal thalamus and pulvinar) in both nonhuman and human primates. In Aim 1, we will establish a semi-automated human-in-the-loop pipeline for data curation, documentation, and sharing. In Aim 2, we will develop multivariate data analysis toolkits with open-access software and documentation. In Aim 3, we will develop integrated tools to test the role of higher order thalamic nuclei in regulating thalamo-cortical functional connectivity. The Data and Analytic Core will collaborate with other project PIs and provide strong support for data sharing, analysis and tool development for both animals’ electrophysiological and humans’ neuroimaging data. Accomplishment of these aims will advance our understanding of thalamo- cortical communications in healthy and diseased brains.

丘脑在注意力、认知控制和决策中起着至关重要的作用， 大规模皮质节点间时间整合和协调的重要枢纽 和皮质下网络之间的功能连接的识别。 跨任务和物种的网络是理解复杂丘脑计算的关键 Conte 中心项目的数据和分析核心。 将在多个方向上为实现中心目标做出贡献 我们将建立一个数据。 管理/共享管道并开发先进的统计和数据驱动的机器学习 用于分析高阶丘脑核神经记录的各种来源的工具 非人类和人类灵长类动物（尤其是丘脑内侧丘脑和丘脑丘脑）。 目标 1，我们将建立一个半自动化的人机交互管道来进行数据管理， 在目标 2 中，我们将开发多元数据分析工具包。 在目标 3 中，我们将开发集成工具来测试开放获取软件和文档。 高阶丘脑核在调节丘脑皮质功能连接中的作用。 数据与分析核心将与其他项目PI合作，为项目提供强有力的支持 动物电生理学和人类电生理学的数据共享、分析和工具开发 神经影像数据的实现将增进我们对丘脑的理解。 健康和患病大脑中的皮质通讯。