CEREBRAL VASOREGULATION IN ELDERLY WITH STROKE

中风老年人的脑血管调节

• 批准号: 7718890
• 负责人: VERA NOVAK
• 金额: $ 1.62万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718890
• 关键词: Activities of Daily Living; Blood Pressure; Cause of Death; Cerebral perfusion pressure; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Elderly; Funding; Goals; Grant; Infarction; Institution; Orthostatic Hypotension; Patients; Positioning Attribute; Research; Research Personnel; Resources; Site; Source; Stroke; United States National Institutes of Health; blood pressure regulation; cerebral hypoperfusion; disability; normotensive; white matter change

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Stroke is the third leading cause of death and the leading cause of disability in older people. The long-term goal of this study is to determine factors that effect cerebral vasoregulation after stroke. The primary hypothesis is that cerebral vasoregulation is impaired in older adults with stroke and cerebral blood flow is dependent on blood pressure. Therefore, cerebral perfusion pressure may be different in stroke-normotensive and stroke-hypertensive patients in upright position. The second hypothesis is that autonomic blood pressure control is altered after stroke, predisposing older people to orthostatic hypotension (OH) and cerebral hypoperfusion during activities of daily living. The third hypothesis is that regional distribution of impaired vasoreactivity may extend beyond the infarct site and cerebral blood flow may be further compromised by white matter changes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 中风是死亡的第三大主要原因，也是老年人残疾的主要原因。 这项研究的长期目标是确定影响中风后脑血管调节的因素。主要假设是，脑血管调节在中风和脑血流量的老年人中受到损害，取决于血压。因此，在直立位置的中风和中风 - 高血压患者中，脑灌注压力可能有所不同。第二个假设是，中风后自主性血压控制会改变，使老年人易于体位性低血压（OH）和日常生活活动期间的脑下降灌注。第三个假设是，受损的血管反应性的区域分布可能会超出梗塞部位，而白质变化可能会进一步损害大脑血流。