EFFECTS OF INTERMEDIATE CYCLIC HYPOXIA ON BLOOD PRESSURE

中度循环缺氧对血压的影响

• 批准号: 7718954
• 负责人: JAMES WOODROW WEISS
• 金额: $ 0.48万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718954
• 关键词: Altitude; Blood Pressure; Blood Vessels; Cardiac Output; Cardiovascular system; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease; End Point; Equilibrium; Exposure to; Functional disorder; Funding; Grant; Hour; Hypoxia; Institution; Mediating; Metabolic; Nerve; Obstructive Sleep Apnea; Pathology; Patients; Protocols documentation; Reporting; Research; Research Personnel; Resources; Source; Testing; Trees; United States National Institutes of Health; Vasoconstrictor Agents; Vasodilator Agents; Week; day; experience; glucose metabolism; hemodynamics; relating to nervous system; respiratory; response; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypoxia experienced environmentally or as a consequence of pathology causes changes in respiratory, cardiovascular, neural and metabolic function. In patients with obstructive sleep apnea, a disease characterized by chronic hypoxia, cardiovascular and metabolic dysfunctions are reported and hypoxia has been implicated as the main factor. Cardiovascular control is mediated locally and centrally and is different along the vascular tree. This study will examine metabolic, hemodynamic and sympathetic responses normal volunteers to a 2-week exposure to nocturnal, cyclic hypoxia (altitude equivalent of 13,000 ft alternating with normoxia). We will test the effect of cyclic nocturnal hypoxia on changes in local vasodilator and vasoconstrictor balance over an entire day and over a 14 day hypoxic exposure. We hypothesize that repeated 8-hour exposures to moderate hypoxia will result in increased sympathetic nerve activity in normal volunteers but also directly decrease vascular tone. Our primary endpoint is to determine blood pressure modulation following a cyclic nocturnal exposure. Subjects will have tests of sympathetic activity, hemodynamics, cardiac output, vascular function, and glucose metabolism at baseline, after exposure, and three days following the end of exposure. Subjects will serve as their own controls and will be followed longitudinally throughout the protocol.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 缺氧在环境上或由于病理的结果导致呼吸道，心血管，神经和代谢功能的变化。 在阻塞性睡眠呼吸暂停的患者中，以慢性缺氧为特征的疾病，据报道心血管和代谢功能障碍，缺氧已被视为主要因素。 心血管控制是在本地和集中介导的，沿血管树是不同的。 这项研究将检查代谢，血液动力学和交感神经反应正常的志愿者对夜间循环缺氧的2周暴露（高度等同于13,000英尺的高度与Normoxia交替）。 我们将在整天和14天的低氧暴露中测试环状夜间缺氧对局部血管扩张剂和血管收缩剂平衡变化的影响。 我们假设重复的8小时暴露于中度缺氧将导致正常志愿者的交感神经活动增加，但也直接降低了血管张力。 我们的主要终点是在循环夜间暴露后确定血压调节。 受试者将对基线，暴露后以及暴露结束后三天进行交感神经，血液动力学，心脏输出，血管功能和葡萄糖代谢的测试。 受试者将作为自己的控制，并将在整个协议中纵向遵循。