EVALUATION OF VITAMIN D REQUIREMENTS DURING PREGNANCY

评估怀孕期间的维生素 D 需求

• 批准号: 7719576
• 负责人: CAROL L WAGNER
• 金额: $ 52.08万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719576
• 关键词: Blood; Child; Cholecalciferol; Computer Retrieval of Information on Scientific Projects Database; Diet; Dose; Effectiveness; Evaluation; Funding; Grant; Growth and Development function; Immune; Infant Development; Infection; Institution; Mothers; Osteogenesis; Pregnancy; Pregnant Women; Property; Purpose; Research; Research Personnel; Resources; Risk; Safety; Skin; Source; Sunlight; Sunscreening Agents; Supplementation; Time; United States Food and Drug Administration; United States National Institutes of Health; Vitamin D; Vitamin D Deficiency; Vitamins; Woman; child bearing; day; fighting; prenatal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to evaluate the effectiveness and safety of higher dose vitamin D in pregnant women. Both mother and baby may be at risk for vitamin D deficiency, even with prenatal vitamin supplementation. vitamin D is important for bone formation, immune (infection-fighting) properties of the body, and normal growth and development of an infant and child. Vitamin D deficiency is increasing in women during their childbearing years, particularly among darker skinned women. This may be due to less vitamin D in modern day diets and less sunlight exposure, espcially using sunscreens and less time spent outdoors. If the mother has low levels of vitamin D, the developing baby also will have low levels of vitamin D. Recent studies suggest that higher doses are necessary for normal blood levels, but exactly how much vitamin D a mother and her developing baby need during pregnancy to achieve and maintain normal vitamin D status is unknown. The Food and Drug Administration (FDA) considers the use of vitamin D3 in this study investigational.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是评估孕妇服用高剂量维生素 D 的有效性和安全性。 即使产前补充了维生素，母亲和婴儿也可能面临维生素 D 缺乏的风险。 维生素 D 对于骨骼形成、身体免疫（抗感染）特性以及婴儿和儿童的正常生长和发育非常重要。 育龄期女性维生素 D 缺乏症日益严重，尤其是肤色较深的女性。 这可能是由于现代饮食中维生素 D 含量较少、阳光照射较少（尤其是使用防晒霜）以及户外活动时间较少所致。 如果母亲的维生素 D 水平较低，那么发育中的婴儿的维生素 D 水平也会较低。最近的研究表明，正常血液水平需要更高的剂量，但母亲和发育中的婴儿在怀孕期间到底需要多少维生素 D达到并维持正常的维生素 D 状态尚不清楚。 美国食品和药物管理局 (FDA) 认为本研究中维生素 D3 的使用属于研究性质。