Training in Host-Pathogen Interactions

宿主与病原体相互作用的培训

基本信息

批准号：
10630267
负责人：
VINCENT T LEE
金额：
$ 13.99万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10630267
关键词：
Training pathogen

项目摘要

The Training Program in Host-Pathogen Interactions (HPI) has supported four (4) predoctoral students per year in the areas of microbial pathogenesis and host defense for the past 9 years. This renewal application seeks to continue our success at this same level and will build upon the many strengths that have been developed at UMCP over these first two funding periods. Our now 29 training faculty are remarkably interactive, allowing our trainees to be exposed to a variety of diverse research techniques and approaches. Multi-disciplinary methodologies to pathogen research will be emphasized to take advantage of our widespread expertise in diverse research areas including biomaterials and nanosciences, computational biology and genomics, microbiology and immunology, and microbial pathogenesis. Trainees in the HPI program will be exposed to a variety of career alternatives, and attend panels and workshops from previous trainees and other professionals who have positions in academia, government, biotech, scientific review, intellectual property, science writing, and entrepreneurship. The didactic component of this training program is organized through the Biological Sciences Training Program (BISI) and the research program is guided by a highly qualified team including the Training Program Co- Directors, an Internal Steering Committee, and an Outside Advisory Committee comprised of experts in bacterial pathogenesis, host defense and T32 administration. Predoctoral students are selected for this program from a large and increasingly qualified applicant pool. Of the 18 trainees supported by the HPI Training Program over the last 5 years, two (2) are from underrepresented populations (11%), and 9/18 trainees (50%) were women. Outcomes of these trainees have been outstanding, with an average of 4 papers per trainee. For the 7 who defended their PhD, the average is 5 papers each and all are now in postdoctoral fellowships (6) or research education (1). Of the 29 faculty trainers, 2 are from underrepresented populations (7%) and 6 are women (21%). This HPI training program takes advantage of the close proximity of UMCP to the NIH, FDA, WRAIR, and the Department of Homeland Security and we have sent students into laboratories from all of these institutions to learn techniques. Finally, our trainees present their research at local, national, and international meetings. Thus, the Training Program in Host- Pathogen Interactions plays a key role in the continued development of HPI at the University of Maryland, College Park.

宿主-病原体相互作用 (HPI) 培训计划已支持四 (4) 名博士前在过去的 9 年里，每年都有学生学习微生物发病机制和宿主防御领域的知识。此续订申请旨在继续我们在同一水平上的成功，并将建立在 UMCP 在前两个资助期间发展起来的许多优势。我们的现在 29 名培训师的互动非常活跃，让我们的学员能够接触到各种多样化的研究技术和方法。病原体的多学科方法将强调研究，以利用我们在不同研究领域广泛的专业知识领域包括生物材料和纳米科学、计算生物学和基因组学，微生物学和免疫学，以及微生物发病机制。 HPI 计划的学员将接触各种职业选择，并参加以前的小组和研讨会在学术界、政府、生物技术、科学界任职的学员和其他专业人士评论、知识产权、科学写作和创业。教学部分该培训计划是通过生物科学培训计划（BISI）组织的该研究计划由高素质团队指导，包括培训计划合作伙伴董事、内部指导委员会和外部咨询委员会由以下人员组成：细菌发病机制、宿主防御和 T32 管理方面的专家。博士前学生是从一个庞大且日益合格的申请者库中被选中参加该计划。 18名练习生中过去 5 年中，有两 (2) 名来自 HPI 培训计划的支持者来自代表性不足的国家人口（11%），9/18 学员（50%）是女性。这些学员的成果优秀，平均每位学员发表 4 篇论文。对于 7 名通过博士学位答辩的人来说，平均每人 5 篇论文，所有人现在都在接受博士后奖学金 (6) 或研究教育 (1).在 29 名教员培训师中，2 名来自代表性不足的人群 (7%)，6 名是女性 (21%)。该 HPI 培训计划利用了 UMCP 与 NIH 邻近的优势， FDA、WRAIR 和国土安全部，我们已将学生派往从所有这些机构的实验室学习技术。最后，我们的学员展示了他们的在地方、国家和国际会议上进行研究。因此，东道国的培训计划病原体相互作用在马里兰大学 HPI 的持续发展中发挥着关键作用马里兰州，大学公园市。

项目成果

期刊论文数量（41）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Extrinsic and intrinsic control of macrophage inflammatory responses.

巨噬细胞炎症反应的外在和内在控制。

DOI：
发表时间：
2013-11
期刊：
影响因子：
5.5
作者：
Cohen, Heather B;Mosser, David M
通讯作者：
Mosser, David M

Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling.

通过氧化还原信号对大肠杆菌中的基因表达和细胞行为进行电子控制。

DOI：
发表时间：
2017-01-17
期刊：
影响因子：
16.6
作者：
Tschirhart, Tanya;Kim, Eunkyoung;McKay, Ryan;Ueda, Hana;Wu, Hsuan;Pottash, Alex Eli;Zargar, Amin;Negrete, Alejandro;Shiloach, Joseph;Payne, Gregory F;Bentley, William E
通讯作者：
Bentley, William E

The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector.

利什曼原虫天然沙蝇载体主要发育阶段的转录组。

DOI：
发表时间：
2017
期刊：
影响因子：
6.4
作者：
Inbar, Ehud;Hughitt, V Keith;Dillon, Laura A L;Ghosh, Kashinath;El;Sacks, David L
通讯作者：
Sacks, David L

Engineering Escherichia coli for enhanced sensitivity to the autoinducer-2 quorum sensing signal.

对大肠杆菌进行工程改造，以增强对 autoinducer-2 群体感应信号的敏感性。

DOI：
发表时间：
2019
期刊：
影响因子：
2.9
作者：
Stephens, Kristina;Zargar, Amin;Emamian, Milad;Abutaleb, Nadia;Choi, Erica;Quan, David N;Payne, Gregory;Bentley, William E
通讯作者：
Bentley, William E

Electrogenetic Signal Transmission and Propagation in Coculture to Guide Production of a Small Molecule, Tyrosine.

共培养中的电遗传信号传输和传播指导小分子酪氨酸的生产。

DOI：
发表时间：
2022-02-18
期刊：
影响因子：
4.7
作者：
VanArsdale, Eric;Pitzer, Juliana;Wang, Sally;Stephens, Kristina;Chen, Chen;Payne, Gregory F;Bentley, William E
通讯作者：
Bentley, William E