HYPOXIA-INDUCIBLE FACTORS IN BPD

BPD 中的缺氧诱导因素

• 批准号: 7716092
• 负责人: Carl W White
• 金额: $ 2.26万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716092
• 关键词: Alveolar; Blood Vessels; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Gases; Gene Expression; Grant; Growth; Hypoxia; Hypoxia Inducible Factor; In Vitro; Institution; Newborn Infant; Phosphotransferases; Procollagen-Proline Dioxygenase; Proteins; Research; Research Personnel; Resources; Source; Structure of parenchyma of lung; United States National Institutes of Health; fetal; in vivo; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aims: (1) Compare effects of hypoxia and normoxia in fetal and newborn lung tissue as to HIFs, HIF-related gene expression, and vascular growth-related kinase activities, and to evaluate the in vitro effect of HIF prolyl hydroxylase domain-containing proteins PHD inhibition on these activities. (2) Examine the effect of PHD inhibition on HIF proteins, HIF-related gene products, and vascular growth-related kinase activities in vivo. (3) Evaluate the effect of PHD inhibition on pulmonary function, gas exchange, and vascular and alveolar development

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 具体目的： （1）比较缺氧和正常氧对HIF，HIF相关的基因表达以及血管生长相关激酶活性的影响，并评估含HIF的蛋白酶羟化酶结构蛋白的体外作用。 （2）检查PHD抑制对HIF蛋白，与HIF相关的基因产物和血管生长相关的激酶活性的影响。 （3）评估博士抑制对肺功能，气体交换以及血管和肺泡发育的影响