HIV Clinical Tumor Biorepository

HIV临床肿瘤生物样本库

• 批准号: 10664027
• 负责人: Suki Subbiah
• 金额: $ 11.65万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664027
• 关键词: Academic Medical Centers; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Affect; African American; Ambulatory Care Facilities; Area; Articulation; Cancer Center; Cancer Diagnostics; Caring; Centers of Research Excellence; Characteristics; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communicable Diseases; Cytotoxic Chemotherapy; Data; Diagnosis; Drug Interactions; Drug resistance; Economics; Enrollment; Ensure; Environment; Epidemic; Ethics; Ethnic Origin; Funding; Genes; Genetic; Goals; Grant; HIV; HIV therapy; HIV-1; HIV/AIDS; Health; Healthcare Systems; Human; Human Resources; Immunologics; Incidence; Individual; Infection; Institution; Laboratories; Link; Louisiana; Malignant Neoplasms; Minority; Minority Groups; Neoplasms; Oncogenic Viruses; Oncology; Outcome; Patients; Performance; Persons; Pharmaceutical Preparations; Phase; Phenotype; Population; Positioning Attribute; Principal Investigator; Privacy; Public Health Schools; Research; Risk; Sampling; Services; System; Therapeutic; Toxic effect; Translational Research; Update; Viral; Viral Cancer; Virus; Virus Latency; Wood material; Work; anticancer research; biobank; biomedical referral center; cancer care; clinical translation; clinically relevant; co-infection; cost; epidemiologic data; health disparity; high risk; human subject protection; immune modulating agents; improved; minority health disparity; mortality; patient population; preference; programs; social; standard of care; stemness; tumor; tumor registry; underserved minority; virus related cancer; volunteer

Abstract: The HCTB Core will assist Junior Principal Investigators (JPIs) with the application of their promising research to the field of clinical viral oncology through prioritization of clinical data and biospecimen collection for JPIs in Phase 2 of Center for Translational Viral Oncology (CTVO). The CTVO will support personnel in the Core who will provide services to the JPIs at reduced/no cost. Consistent with the articulated theme of Phase 2 CTVO, the HCTB, organized and directed by Drs. Subbiah and Bonstaff, collects biospecimens from the HIV/AIDS Malignancy Program and from other oncology clinics that evaluate, diagnose and treat patients with viral associated malignancies. These patients are disproportionately minorities, mostly African American. The overarching goal of HCTB is to assist JPIs with performance of high-quality translational research utilizing linked biospecimens and clinical data from patients receiving care at the University Medical Center - Infectious Diseases Center (UMCNO-IDC) and its affiliated partner, HIV/AIDS Malignancy Program. Use of de-identified human samples will inform and ensure clinical relevance of mechanistic studies and promote clinical translation. Through this effort, we seek to improve health outcomes for underserved HIV+ patients at risk for virus-associated cancers. In addition, access to these unique samples provides JPI's with a competitive edge as they apply for independent grant funding. The HCTB Core will support proposed by JPI research through the following Specific Aims: 1) To expand a HIV outpatient clinic-based system for collection of linked clinical data and biospecimens from HIV+ patients in New Orleans who are at high risk for virus-associated cancers; 2) To ensure storage of high-quality HIV+ biospecimens for easy access by JPIs; 3) To perform timely delivery/shipment of HIV+ biospecimens to internal and external collaborators; 4) To promote collaboration between JPIs and the staff of the Louisiana Tumor Registry (LTR) at LSU School of Public Health to provide access to updated epidemiologic data and analyses on the distribution of viral tumors in underserved minority populations in our State. Funding to the CTVO will support personnel employed within the Core and allow services to be provided at reduced cost to the JPIs while also providing for institutional ethical compliance and insuring protection of human subjects and their privacy. Leveraging involvement of several Centers and Programs at LSUHSC ensures ongoing support and function of this Core following conclusion of the COBRE funding.

摘要：HCTB 核心将协助初级首席研究员 (JPI) 应用他们的研究成果 通过优先考虑临床数据和生物样本，在临床病毒肿瘤学领域开展有前景的研究 转化病毒肿瘤学中心 (CTVO) 第二阶段的 JPI 收集。 CTVO将支持 核心人员将以较低成本/免费向 JPI 提供服务。与铰接一致 第二阶段 CTVO 的主题是 HCTB，由 Drs 组织和指导。 Subbiah 和 Bonstaff，收集 来自艾滋病毒/艾滋病恶性肿瘤计划和其他肿瘤诊所的生物样本，用于评估， 诊断和治疗患有病毒相关恶性肿瘤的患者。这些患者比例不成比例 少数民族，主要是非裔美国人。 HCTB 的总体目标是协助 JPI 实现以下绩效： 利用关联的生物样本和接受护理的患者的临床数据进行高质量的转化研究 大学医学中心 - 传染病中心 (UMCNO-IDC) 及其附属合作伙伴， 艾滋病毒/艾滋病恶性肿瘤计划。使用去识别化的人类样本将告知并确保临床相关性 机制研究并促进临床转化。通过这一努力，我们寻求改善健康 服务不足的 HIV+ 患者面临病毒相关癌症风险的结果。此外，还可以访问这些 独特的样本为 JPI 申请独立拨款资金提供了竞争优势。这 HCTB 核心将通过以下具体目标支持 JPI 研究提出的建议： 1) 扩大艾滋病毒 基于门诊诊所的系统，用于收集来自艾滋病毒+患者的相关临床数据和生物样本 新奥尔良是病毒相关癌症的高危人群； 2) 确保储存高质量的HIV+ 便于 JPI 获取的生物样本； 3) 及时交付/运送 HIV+ 生物样本至 内部和外部合作者； 4) 促进 JPI 与路易斯安那州工作人员之间的合作 路易斯安那州立大学公共卫生学院肿瘤登记处 (LTR)，提供更新的流行病学数据和 对我国服务不足的少数群体中病毒肿瘤的分布进行分析。资助 CTVO 将支持核心内雇用的人员，并允许以降低的成本提供服务 JPI，同时还规定机构道德合规性并确保对人类受试者的保护 以及他们的隐私。利用 LSUHSC 多个中心和项目的参与，确保持续进行 COBRE 资助结束后，该核心的支持和职能。