The Adolescent Master Protocol (AMP) Up Series Project

青少年大师协议 (AMP) Up 系列项目

基本信息

批准号：
10663924
负责人：
Katherine K. Tassiopoulos
金额：
$ 23.6万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-18 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10663924
关键词：
15 year old 18 year old Address Adherence Adolescence Adolescent Adolescent and Young Adult Adult Age Aging Alcohol consumption Anti-Retroviral Agents Behavior Body Composition Bone Density Brain Cardiac Cardiopulmonary Cardiovascular Diseases Caring Centers for Disease Control and Prevention (U.S.)Cervical Child Clinic Clinic Visits Clinical Cohort Studies Data Data Collection Disease Disease remission Emotional Enrollment Ensure Epigenetic Process Family dynamics Generations Genetic Goals Growth Gynecologic HIV HIV Infections Health Health behavior and outcomes Healthcare Hearing Human Papillomavirus Immunologic Factors Individual Infant Inflammatory Influentials Intervention Kidney Language Lesion Long-Term Effects Longterm Follow-up Lung Medical Mental Health Metabolic Nervous System Physiology Neurocognitive Neurologic Nutritional Oral Oral health Organ Outcome Participant Pediatric HIV/AIDS Cohort Study Perinatal Persons Pharmaceutical Preparations Physical assessment Postpartum Period Productivity Protocols documentation Psyche structure Publications Research Research Design Role Self Management Series Sex Behavior Sexual Maturation Sexually Transmitted Diseases Social Functioning Social support Structure Tobacco use Toxic effect Viral Viremia Visit Vocation Woman antiretroviral therapy behavioral health bone cardiovascular disorder risk cardiovascular risk factor clinical care cohort comparison group design early childhood emotional functioning flexibility follow-up health care service utilization health management high risk innovation neurodevelopment pediatric human immunodeficiency virus perinatal HIV physical conditioning pubertal timing recreational drug use reproductive reproductive outcome scale up social social factors sociodemographics structural determinants substance use treatment adherence treatment response vaccine efficacy young adult

项目摘要

PROJECT SUMMARY The Centers for Disease Control and Prevention estimates that in 2016, there were 11,915 persons with perinatally-acquired HIV (PHIV) in the U.S., including 10,101 adolescents and young adults. Globally, 1.7 million children under the age of 15 are living with HIV and with effective antiretroviral medications (ARVs) are expected to survive into adolescence, young adulthood and beyond. The Adolescent Master Protocol (AMP) was designed to evaluate long-term effects of HIV infection and ARVs on multiple domains. AMP enrolled 451 children with PHIV between ages 7-16 years and 227 children living with perinatal HIV exposure but uninfected (PHEU) from 2007-09. The AMP Up and AMP Up Lite studies (AMP Up Series) were developed to allow for continued follow-up of young adults with PHIV (YAPHIV) beyond 18 years of age, including AMP participants, to assess physical and mental health as they transition to adulthood. These innovative studies share similar objectives and are designed to facilitate long- term follow-up with annual online and medical chart abstracted data collection. AMP has been highly productive with numerous influential publications. AMP Up has yielded important information – including the role of social support and ability to self-manage health care on a successful transition to adult clinical care, and the high risk of postpartum viremia and early HPV-associated cervical lesions. Yet the long-term effects of HIV and ARV on health in young adulthood are still unfolding. The comprehensive data collected since early childhood on a substantial subset of AMP Up participants previously in AMP provides the invaluable opportunity to assess how early HIV and ARV, mental health, neurocognitive function, and family dynamics impact adult outcomes. The specific aims of the AMP Up Series are to: 1. Define the impact of PHIV infection, ARVs, and individual, social and structural factors on: the transition to adulthood and adult care; brain structure and neurological functioning; academic, vocational, emotional and social functioning; mental health; medication and health care adherence; sexual behaviors; and substance use. 2. Identify infectious and non-infectious complications of HIV and their associations with ARVs and HIV. 3. Investigate genetic, epigenetic, virologic, inflammatory, and immunologic factors which impact the course of HIV infection, its complications, the response to treatment, and potential for HIV remission/cure.

项目概要美国疾病控制与预防中心估计，2016 年，有 11,915 人患有此病美国围产期感染艾滋病毒 (PHIV)，包括 10,101 名青少年和年轻人，全球感染率为 1.7。百万 15 岁以下儿童感染艾滋病毒并接受有效的抗逆转录病毒药物 (ARV) 预期能存活到青春期、青年期及以后。青少年主方案 (AMP) 旨在评估 HIV 感染的长期影响和 AMP 招募了 451 名年龄在 7-16 岁之间的 PHIV 儿童和 227 名儿童。 2007 年 9 月期间接触过艾滋病毒但未感染 (PHEU) 的 AMP Up 和 AMP Up Lite。研究（AMP Up 系列）的开发是为了对感染 PHIV 的年轻人进行持续随访 (YAPHIV) 18 岁以上（包括 AMP 参与者），以评估他们的身心健康状况这些创新研究有着相似的目标，旨在促进长期的过渡。通过年度在线和病历摘要数据收集进行学期随访。 AMP 的生产力很高，出版了许多有影响力的出版物。信息——包括社会支持的作用和自我管理医疗保健的能力对成功的向成人临床护理的过渡，以及产后病毒血症和早期 HPV 相关宫颈癌的高风险然而，艾滋病毒和抗逆转录病毒药物对青少年健康的长期影响仍在显现。之前从幼儿期开始收集的 AMP Up 参与者的重要子集的综合数据 AMP 提供了宝贵的机会来评估早期 HIV 和 ARV、心理健康、神经认知 AMP Up 系列的具体目标是： 1. 定义 PHIV 感染、抗逆转录病毒药物以及个人、社会和结构因素对以下方面的影响：成年期和成人护理；大脑结构和神经功能；社会功能；心理健康；药物和保健依从性；以及药物使用。 2. 识别艾滋病毒的感染性和非感染性并发症及其与抗逆转录病毒药物和艾滋病毒的关系。 3. 研究影响病程的遗传、表观遗传、病毒学、炎症和免疫学因素 HIV 感染、其并发症、治疗反应以及 HIV 缓解/治愈的潜力。