Promoting Genetic Counseling among African American Women with Hereditary Risk for Breast Cancer

促进有乳腺癌遗传风险的非裔美国女性的遗传咨询

基本信息

批准号：
10664032
负责人：
Vida Ann Henderson
金额：
$ 16.28万
依托单位：
FRED HUTCHINSON CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-10-16 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10664032
关键词：
Address Affect African American Applications Grants Award Awareness BRCA1 gene Behavioral Behavioral Model Breast Cancer Risk Factor Cancer Center Chicago Clinical Research Counseling Coupled DNA Sequence Alteration Data Decision Aid Decision Making Development Development Plans Diffusion Discipline Disparity Distress Early Diagnosis Educational workshop Ensure Epigenetic Process Family member Federally Qualified Health Center Funding General Population Genes Genetic Genetic Counseling Genetic Services Goals Grant Guidelines High Risk Woman Illinois Individual Inequity Inherited Intervention Knowledge Lead Malignant Neoplasms Mentors Mentorship Methods Minority Women Mission Multimedia Neighborhood Health Center Not Hispanic or Latino Pamphlets Participant Pathogenicity Pathway Analysis Physicians Population Heterogeneity Positioning Attribute Primary Health Care Productivity Provider Psychosocial Factor Public Health Public Health Schools Race Randomized, Controlled Trials Recommendation Research Research Activity Research Personnel Risk Scientist Self Determination Services Social Network Structure Testing Time Training Training Activity Translational Research United States United States Preventative Services Task Force Universities Variant Woman Work Writing cancer genetics cancer health disparity cancer prevention career career development cost design effectiveness testing emotional distress ethnic minority genetic risk assessment genetic testing health service use hereditary risk high risk high risk population hormone receptor-negative improved intrinsic motivation malignant breast neoplasm meetings minority communities mortality multidisciplinary precision medicine racial minority risk perception skill acquisition skills social social relationships socioeconomics systemic barrier theories tool tumor underserved minority uptake video coaching

项目摘要

1 The long-term career goal of this K01 project is to gain training and mentorship that will prepare me for a career 2 as an independent and successful externally funded investigator in the field of cancer health disparities. Over 3 the next 5 years, my career objectives are to: 1) develop and lead experimental interventions; 2) gain further 4 expertise in translational science; 3) acquire skills in quantitative analysis, including social network analysis; and 5 4) enhance my ability to write competitive grant applications and increase my scholarly productivity. With my 6 primary mentor, Dr. Marian Fitzgibbon, I have assembled a strong team of co-mentors and advisors (including a 7 biostatistician) to guide me through the proposed training and research activities. The proposed career 8 development plan is structured to ensure that I achieve training milestones through didactic coursework, career 9 development workshops, and attendance at national scientific meetings. The University of Illinois at Chicago 10 (School of Public Health and Cancer Center) are committed to supporting my career development and providing 11 the protected time needed to achieve my career and research goals. The overall objective of this K01 research 12 project is to test the effectiveness of a culturally targeted video, previously developed by our research team, on 13 promoting genetic counseling attendance among African American (AA) women determined to be at high risk for 14 breast cancer through cancer genetic risk assessment at a Federally Qualified Health Center. Uptake of genetic 15 services is particularly low among high-risk AA women, who carry a disproportionate burden of breast cancer 16 mortality. Further, although testing close relatives of individuals who test positive for a pathogenic variant might 17 curtail breast cancer disparities attributable to hereditary risk, it is unclear how counseled or tested individuals 18 influence their social and familial networks. Thus, my central hypothesis is that the culturally targeted video will 19 increase genetic counseling attendance among participants compared to those who receive a genetic counseling 20 brochure. The proposed Specific Aims are to: 1) compare the effects of the video and brochure on genetic 21 counseling attendance among AA women at high risk for breast cancer; 2) test how psychosocial factors 22 (knowledge, intrinsic motivation, risk perception, distress) affect relationships between intervention exposures 23 (video/brochure) and genetic counseling attendance; and 3) compare the impact of intervention exposures 24 (video/brochure) on diffusion of knowledge through social network analysis. My prior training, coupled with the 25 skills that I will acquire during the award period, will equip me to successfully conduct the proposed research 26 and position me to continue my work to address breast cancer disparities that persist among high-risk AA women. 27 28 29 30 31 32

1 这个 K01 项目的长期职业目标是获得培训和指导，为我的职业生涯做好准备 2 作为癌症健康差异领域独立且成功的外部资助研究者。超过 3 未来 5 年，我的职业目标是： 1）开发并领导实验干预措施； 2）进一步获得收益 4 转化科学方面的专业知识； 3）获得定量分析技能，包括社交网络分析；和 5 4) 增强我撰写有竞争力的资助申请的能力并提高我的学术生产力。与我的 6 首席导师 Marian Fitzgibbon 博士，我组建了一支强大的共同导师和顾问团队（包括 7 生物统计学家）指导我完成拟议的培训和研究活动。拟定职业制定了 8 个发展计划，以确保我通过教学课程、职业生涯实现培训里程碑 9 次开发研讨会，并出席国家科学会议。伊利诺伊大学芝加哥分校 10（公共卫生学院和癌症中心）致力于支持我的职业发展并提供 11 实现我的职业和研究目标所需的受保护时间。本次K01研究的总体目标 12 项目是测试我们的研究团队之前开发的针对文化的视频的有效性， 13 促进被确定患有遗传病高风险的非裔美国 (AA) 女性接受遗传咨询 14 通过联邦合格健康中心的癌症遗传风险评估发现乳腺癌。遗传基因的摄取 15 服务在高风险 AA 女性中尤其低，她们承受着不成比例的乳腺癌负担 16 死亡率。此外，尽管对致病性变异检测呈阳性的个体的近亲进行检测可能会 17 减少遗传风险导致的乳腺癌差异，目前尚不清楚如何对个人进行咨询或测试 18 影响他们的社交和家庭网络。因此，我的中心假设是，具有文化针对性的视频将 19 与接受遗传咨询的参与者相比，参与者的遗传咨询出席率有所提高 20 册。拟议的具体目标是： 1) 比较视频和手册对遗传的影响 21 名 AA 乳腺癌高危女性参加咨询； 2）测试心理社会因素如何 22（知识、内在动机、风险感知、痛苦）影响干预措施之间的关系 23（视频/小册子）和遗传咨询出席； 3）比较干预措施的影响 24（视频/小册子）关于通过社交网络分析传播知识。我之前的训练，再加上我将在奖励期间获得 25 项技能，使我能够成功地进行拟议的研究 26 并让我能够继续努力解决高风险 AA 女性中持续存在的乳腺癌差异。 27 号 28 29 30 31 32

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pilot study of a culturally sensitive intervention to promote genetic counseling for breast cancer risk.

一项文化敏感干预措施的试点研究，以促进乳腺癌风险的遗传咨询。

DOI：
发表时间：
2022-06-25
期刊：
影响因子：
2.8
作者：
Henderson, Vida;Madrigal, Jessica M;Kendall, Le' Chaun;Parekh, Pooja;Newsome, Jennifer;Chukwudozie, Ifeanyi Beverly;Comer;Coffey, Vickii;Grumbach, Giesela;Spencer, Shirley;Rodgers, Carolyn;Kaur, Ravneet;Balay, Lara;Maga, Tar
通讯作者：
Maga, Tar

Population screening to identify women at risk for hereditary breast cancer syndromes: The path forward or the road not taken?

通过人口筛查来识别有遗传性乳腺癌综合征风险的女性：前进的道路还是未走的道路？