UPDATE AND EXPAND VITAL RESOURCES

更新和扩展重要资源

• 批准号: 7959202
• 负责人: ROBERT P DOTTIN
• 金额: $ 31.04万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959202
• 关键词: 10 year old; Accreditation; Address; Animals; Area; Behavior; Caring; Cellular Structures; Censuses; Certification; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Data; Development; Drug abuse; Electron Microscope; Electron Microscopy; Funding; Gene Structure; Genes; Grant; IACUC; Image; Imagery; Immunology; Institution; Internet; Investigation; Laboratory Animals; Lasers; Microscope; Modeling; Molecular; Monitor; Nanotechnology; Nervous system structure; Neurobiology; Organic Chemistry; Output; Pain; Recruitment Activity; Research; Research Personnel; Resources; Running; Sampling; Scanning; Scientist; Source; Time; United States National Institutes of Health; Update; Vertebrates; Veterinarians; Video Microscopy; analog; animal care; animal facility; base; bioimaging; college; digital; digital imaging; experimental analysis; gene function; health disparity; image processing; instrument; meetings; programs; protein structure function; repaired; research study; transmission process; 10 year old; Accreditation; Address; Animals; Area; Behavior; Caring; Cellular Structures; Censuses; Certification; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Data; Development; Drug abuse; Electron Microscope; Electron Microscopy; Funding; Gene Structure; Genes; Grant; IACUC; Image; Imagery; Immunology; Institution; Internet; Investigation; Laboratory Animals; Lasers; Microscope; Modeling; Molecular; Monitor; Nanotechnology; Nervous system structure; Neurobiology; Organic Chemistry; Output; Pain; Recruitment Activity; Research; Research Personnel; Resources; Running; Sampling; Scanning; Scientist; Source; Time; United States National Institutes of Health; Update; Vertebrates; Veterinarians; Video Microscopy; analog; animal care; animal facility; base; bioimaging; college; digital; digital imaging; experimental analysis; gene function; health disparity; image processing; instrument; meetings; programs; protein structure function; repaired; research study; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Scientists at the Center for Study of Gene Structure and Function (Gene Center) at Hunter College use animals in their outstanding research programs. Their investigations are monitored by an active Institutional Animal Care and Use Committee (IACUC) committee and supported by a well run Animal Facility. The facility maintains a variety of vertebrate animal species. We have made major efforts during the past funding period to upgrade and expand the Animal Care Facility. Because of the increased research involving animals, the animal census has increased significantly. To maintain adequate care and surveillance of the animals, it is now essential to hire a full-time veterinarian. We plan to recruit and hire a veterinarian with RCMI grant funds. At the end of the next five year period, the institution will provide a permanent line for this hire. These improvements will enable research scientists at the Gene Center to be more productive, especially in research that addresses health disparities. The planned improvements, including the full-time veterinarian, will also bring the facility in line with Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) standards for certification. The Digital Bio-Imaging Core Facility, established in 1995, offers visualization of sub-cellular structures with digital image processing and video microscopy. The facility also provides for laser scanning analysis of experimental data. Gene Center Researchers use the facility to conduct pioneering research in the following areas: Damage and Repair of the Nervous System, Neurobiology of Drug Abuse, Molecular Mechanism of Pain, Protein Structure and Function, Molecular Basis of Behavior, Immunology and Development, Nanotechnology and Bio-Organic Chemistry. Our plan is to replace an obsolete ten-year-old confocal microscope with an instrument that meets our research needs. We also plan to purchase a digital transmission electron microscope (TEM) to replace a very old and obsolete analog model so that we may serve the needs of our researchers. The two microscopes will be located in the Digital Bioimaging Core Facility, which will be renovated using institutional funds to accommodate the instruments (see appendix 27. We are also requesting RCMI grant support to hire a research assistant with expertise in preparing samples for electron microscopy. This research assistant will be supervised by Dr. Lloyd Williams, the manager of the facility. The proposed improvements will significantly upgrade the facility, while making it possible to perform sophisticated and quantitative experiments and to share research results through the internet in real time. These improvements will make a major impact on the research output of the Gene Center.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 基因结构和功能研究中心的科学家（基因中心）在其杰出的研究计划中使用动物。他们的调查由活跃的机构动物护理和使用委员会（IACUC）委员会监控，并得到运行良好的动物设施的支持。该设施维持各种脊椎动物。在过去的资金期间，我们已经付出了重大努力，以升级和扩大动物护理设施。由于涉及动物的研究增加，动物的人口普查已大大增加。为了维持对动物的足够护理和监视，现在必须聘请全职兽医。我们计划通过RCMI赠款资金招募和聘请兽医。在接下来的五年期结束时，该机构将为这份雇用提供永久性的线路。这些 改进将使基因中心的研究科学家提高生产力，尤其是在解决健康差异的研究中。包括全职兽医在内的计划的改进还将使该设施与协会进行评估和认证实验室动物护理（AAAALAC）的认证标准。 建立于1995年的数字生物成像核心设施可视化具有数字图像处理和视频显微镜的亚细胞结构。该设施还提供了实验数据的激光扫描分析。基因中心研究人员使用该设施进行开创性研究 区域：神经系统的损害和修复，药物滥用的神经生物学，疼痛的分子机制，蛋白质结构和功能，行为的分子基础，免疫学和发育，纳米技术和生物有机化学。我们的计划是用满足我们研究需求的仪器代替过时的十年共聚焦显微镜。我们还计划购买数字传输电子显微镜（TEM），以替换一个非常旧的和过时的模拟模型，以便我们可以满足研究人员的需求。这两个显微镜将位于数字生物成像核心设施中，该设施将使用机构资金进行翻新以容纳这些乐器（请参阅附录27。我们还请求RCMI Grant 支持聘请具有专业知识的研究助理，以准备电子显微镜样品。该研究助理将由该设施经理劳埃德·威廉姆斯（Lloyd Williams）博士进行监督。拟议的改进将大大升级该设施，同时可以进行复杂和定量的实验，并实时通过互联网共享研究结果。这些改进将对基因中心的研究产出产生重大影响。