Career Enhancement Core

职业提升核心

基本信息

批准号：
10540786
负责人：
JORDAN W SMOLLER
金额：
$ 11.06万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10540786
关键词：
Address Advocacy Arizona Award Behavior Biology Biomedical Engineering Brain Brain Diseases Center for Translational Science Activities Clinical Clinical Research Clinical Sciences Collaborations Colorado Development Disease Early Intervention Educational Curriculum Educational Status Environmental Risk Factor Etiology Faculty Family Family member Fostering Funding Future Gender Genes Genetic Genomics Health Healthcare Healthcare Systems Heart Home Hormones Hospitals Human Immune Individual Infrastructure Institution Interdisciplinary Study Longevity Major Depressive Disorder Massachusetts Medical Medicine Mental disorders Mentors Mentorship Metabolic Methodology Methods Modeling Moods Morbidity - disease rate Outcome Participant Pathology Pathway interactions Pattern Persons Physiology Play Policies Population Pregnancy Complications Prevention Proteomics Public Health Schools Recording of previous events Research Research Personnel Research Project Grants Resources Rest Role Schools Science Scientist Sex Differences Site Strategic Planning Structure Supervision System Therapeutic Therapeutic Research Training Training and Infrastructure Translating Translational Research Translations United States National Institutes of Health Universities Woman Women&apos s Health Work attenuation biomedical resource career career development didactic education disability empowerment experience fetal programming gender disparity health care service utilization health difference health disparity heart function imaging facilities improved insight interest knowledge translation medical schools metabolomics multidisciplinary new technology next generation novel strategies offspring personalized medicine pre-clinical research precision medicine preclinical study prenatal stress programs research and development sex skills social steroid hormone success translational model

项目摘要

The Career Enhancement Core (CEC) will contribute to training the next generation of scientists and clinician- scientists as leaders in the fields of women's health and sex differences in medicine. They will be empowered to contribute to understanding sex-dependent vulnerabilities to major psychiatric and associated medical disorders. Our SCORE focuses on understanding sex differences in major depression and associated autonomic physiology and translation of this knowledge into the development of sex-dependent therapeutics. Defining the impact of gender in addition to sex, will prepare our participants to think about translation of scientific findings to policy and advocacy. Training the next generation as to the importance of sex and gender in understanding medicine and healthcare will be critical in realizing the national strategic plan to develop precision or personalized medicine. The SCORE faculty have a long history of training people to think about sex and gender in medicine. We will integrate the training infrastructures of the SCORE partners focused on women's health and sex differences in diseases to provide new opportunities, expand resources, add new faculty, and educate trainees with regard to new technologies and approaches. The CEC will capitalize on a long tradition of interdisciplinary research collaborations on sex differences and women's health among investigators across these institutions, including a previous ORWH P50 SCOR that focused on sex differences in major depression across HMS, CSU, and the University of Arizona. We have made available to our mentees a vast array of biomedical resources across institutions that address scientific questions essential to improving women's health. To enhance the careers of SCORE trainees, the CEC will specifically: 1) Integrate levels of training and thought about etiologic mechanisms at basic and clinical levels for sex differences, and for gender and health disparities at the policy level. 2) Mentor trainees from a team perspective that exposes them to different levels of analysis from mentors with complementary expertise. 3) Provide access to material and faculty resources that will enhance the success of the initial group of candidates. The CEC infrastructure will provide a model that can be generalized to others in the future, playing a convening/integrative role in training the next generation across fields, methodologies and institutions. We are also committed to training a diverse biomedical workforce, as exemplified by the first set of participants and investigators included in this SCORE. Two junior faculty will serve as initial models for implementing this CEC based on their interests in sex differences in immune pathways in the brain, fetal programming and offspring brain development, and impact of pregnancy complications on offspring brain and cardiac function. Finally, we will (4) provide seed funding to supplement work with the preclinical studies and ultimately translate to the human studies. In summary, this core will create individually-tailored curricula that will take advantage of mentorship strengths across institutions and foster the professional skills of a next generation of rising stars for women's health research.

职业增强核心（CEC）将有助于培训下一代科学家和临床医生-科学家是女性健康和医学性别差异领域的领导者。他们将是有权帮助了解主要精神科和相关疾病的性别依赖性脆弱性医疗疾病。我们的 SCORE 侧重于了解重度抑郁症和相关抑郁症的性别差异自主生理学以及将这些知识转化为性别依赖性疗法的发展。除了性别之外，定义性别的影响将使我们的参与者准备好考虑翻译科学发现到政策和宣传。培训下一代了解性和性别的重要性了解医药卫生对于实现国家发展战略规划至关重要精准或个性化医疗。 SCORE 教师在培养人们思考方面有着悠久的历史性和医学中的性别。我们将整合 SCORE 合作伙伴的培训基础设施，重点关注妇女健康和疾病中的性别差异提供新的机会、扩大资源、增加新的教师，并对学员进行新技术和方法方面的教育。 CEC 将利用关于性别差异和妇女健康的跨学科研究合作的悠久传统这些机构的调查员，包括之前关注性别差异的 ORWH P50 SCOR HMS、CSU 和亚利桑那大学的重度抑郁症患者。我们已经向我们的学员提供了跨机构的大量生物医学资源，解决对改善疾病至关重要的科学问题女性健康。为了提升 SCORE 学员的职业生涯，CEC 将具体： 1) 整合 SCORE 学员的水平关于性别差异和性别的基础和临床病因机制的培训和思考以及政策层面的健康差异。 2）从团队的角度指导学员，让他们接触到来自具有互补专业知识的导师的不同级别的分析。 3) 提供获取材料和教师资源将提高第一批候选人的成功率。 CEC基础设施将提供一个将来可以推广到其他人的模型，在培训中起到召集/整合作用跨领域、方法论和机构的下一代。我们还致力于培养多元化的生物医学人员，如本 SCORE 中包含的第一组参与者和研究人员所示。两名初级教师将根据他们对性的兴趣作为实施该 CEC 的初始模型大脑免疫通路、胎儿编程和后代大脑发育的差异及其影响妊娠并发症对后代大脑和心脏功能的影响。最后，我们将 (4) 提供种子资金补充临床前研究的工作，并最终转化为人体研究。综上所述，这核心将创建个性化的课程，充分利用各个领域的指导优势机构并培养下一代女性健康研究新星的专业技能。