Effects of Dietary Sodium and Potassium Intake on Subclinical and Clinical Cardio

膳食钠和钾摄入量对亚临床和临床心脏的影响

• 批准号: 7474170
• 负责人: Cheryl Ann Marie Anderson
• 金额: $ 14.09万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7474170
• 关键词: Advisory Committees; African American; Age; American; Antihypertensive Agents; Biomedical Research; Blood Pressure; Body Weight; Cardiovascular Diseases; Clinical; Clinical Research; Cohort Studies; Data Analyses; Data Collection; Development; Diet; Dietary Potassium; Dietary Sodium; Disease Outcome; Doctor of Philosophy; Elderly; Environment; Epidemiologist; Epidemiology; Excretory function; Faculty; Female; Funding; Gender; Goals; Health; Health behavior; Hour; Hypertension; Institution; Intake; International; K-Series Research Career Programs; Kidney Diseases; Left Ventricular Mass; Measures; Medical; Medicine; Mentors; Minority; Nutritional; Obesity; Observational Study; Overweight; Patients; Population Study; Positioning Attribute; Potassium; Proxy; Public Health Schools; Research; Research Personnel; Scientist; Sodium; Source; Subgroup; Testing; Training; Underserved Population; Universities; Weight; abstracting; blood pressure regulation; cardiovascular disorder prevention; career; cohort; interest; male; nutrition; prevent; professor; prospective; research and development; skills; urinary

DESCRIPTION (provided by applicant): This is Dr. Cheryl Anderson's application for a NHLBI Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01). Cheryl Anderson, PhD, MPH is a nutritional epidemiologist and has a faculty position as an Assistant Scientist in the department of Epidemiology at the Johns Hopkins University Bloomberg School of Public Health (Hopkins). Dr. Anderson's research interests center around nutrition as a means to prevent cardiovascular disease (CVD) in minority and underserved populations. Her long-term goal is to combine her interdisciplinary training in health behavior, epidemiology and nutritional sciences to conduct observational and clinical studies of CVD. In this application, Dr. Anderson outlines a career development and research plan that provides critical new scientific skills and extend her research capabilities, to enhance her development into an independent scientist. Lawrence Appel, MD, MPH will mentor Dr. Anderson in the proposed research. Dr. Appel is a recognized expert in CVD prevention through both pharmacologic and non-pharmacologic (diet) approaches. He is a professor of medicine, epidemiology and international health (nutrition) at the Johns Hopkins Medical Institutions. Dr. Anderson has also assembled an advisory committee of accomplished researchers to provide scientific and career development advice, as well as evaluate her progress. The objectives of Dr. Anderson's research plan are to examine the main and interactive effects of dietary sodium and potassium intake (measured by 24-hour urinary excretion) on echocardiographic left ventricular (LV) mass and clinical CVD. Her research will be conducted within the context of the NIH-funded African American Study of Kidney Disease and Hypertension (AASK) study. She will use do secondary analyses of data from both the AASK trial and AASK cohort study. The ongoing AASK cohort study is a prospective, observational study that is an extension of the AASK trial which tested the effects of three anti-hypertensive therapies and two levels of blood pressure control on progression of kidney disease. Dr. Anderson will also conduct additional (de-novo) data collection, in a subcohort of AASK, to characterize the sources of dietary sodium and potassium in the cohort - a highly relevant clinical issue. Dr. Anderson is in a supportive institutional environment at Hopkins that maximizes her potential to establish an independent, competitive research agenga that will support a prolific academic career. (End of Abstract)

描述（由申请人提供）： 这是谢丽尔·安德森（Cheryl Anderson）博士申请NHLBI指导职业发展奖，以促进生物医学研究的教师多样性（K01）。 Cheryl Anderson博士，MPH是一名营养流行病学家，在约翰·霍普金斯大学彭博公共卫生学院（Hopkins）的流行病学系担任助理科学家。安德森博士的研究兴趣围绕营养，作为预防少数民族和服务不足人群中心血管疾病（CVD）的手段。她的长期目标是结合她在健康行为，流行病学和营养科学方面的跨学科培训，以进行CVD的观察和临床研究。在此应用程序中，安德森博士概述了一项职业发展和研究计划，该计划提供了至关重要的新科学技能并扩展了她的研究能力，从而将她的发展改善为独立的科学家。 MD，MPH的Lawrence Appel将在拟议的研究中指导Anderson博士。 Appel博士是通过药理学和非药物（饮食）方法公认的CVD预防专家。他是约翰·霍普金斯医学机构的医学，流行病学和国际健康（营养）教授。安德森（Anderson）博士还召集了一个成熟研究人员的咨询委员会，以提供科学和职业发展建议，并评估她的进步。安德森（Anderson）研究计划的目标是研究饮食中钠和钾摄入量（通过24小时尿液排泄）对超声心动图左心室（LV）质量和临床CVD的主要和交互作用。她的研究将在NIH资助的非裔美国人肾脏疾病和高血压研究（AASK）研究的背景下进行。她将使用来自AASK试验和AASK队列研究的数据进行辅助分析。正在进行的AASK队列研究是一项前瞻性，观察性的研究，是AASK试验的扩展，该研究测试了三种抗高血压疗法的影响以及两种水平的血压控制对肾脏疾病进展的影响。安德森博士还将在ASK的亚aask中进行额外的（De -Novo）数据收集，以表征同类中饮食中的钠和钾的来源，这是一个高度相关的临床问题。安德森（Anderson）博士处于霍普金斯（Hopkins）的支持性机构环境中，该环境最大程度地提高了她建立独立，竞争性研究的潜力，该研究将支持多产的学术生涯。 （抽象的结尾）