Effects of Dietary Sodium and Potassium Intake on Subclinical and Clinical Cardio

膳食钠和钾摄入量对亚临床和临床心脏的影响

• 批准号: 7474170
• 负责人: Cheryl Ann Marie Anderson
• 金额: $ 14.09万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7474170
• 关键词: Advisory Committees; African American; Age; American; Antihypertensive Agents; Biomedical Research; Blood Pressure; Body Weight; Cardiovascular Diseases; Clinical; Clinical Research; Cohort Studies; Data Analyses; Data Collection; Development; Diet; Dietary Potassium; Dietary Sodium; Disease Outcome; Doctor of Philosophy; Elderly; Environment; Epidemiologist; Epidemiology; Excretory function; Faculty; Female; Funding; Gender; Goals; Health; Health behavior; Hour; Hypertension; Institution; Intake; International; K-Series Research Career Programs; Kidney Diseases; Left Ventricular Mass; Measures; Medical; Medicine; Mentors; Minority; Nutritional; Obesity; Observational Study; Overweight; Patients; Population Study; Positioning Attribute; Potassium; Proxy; Public Health Schools; Research; Research Personnel; Scientist; Sodium; Source; Subgroup; Testing; Training; Underserved Population; Universities; Weight; abstracting; blood pressure regulation; cardiovascular disorder prevention; career; cohort; interest; male; nutrition; prevent; professor; prospective; research and development; skills; urinary

DESCRIPTION (provided by applicant): This is Dr. Cheryl Anderson's application for a NHLBI Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01). Cheryl Anderson, PhD, MPH is a nutritional epidemiologist and has a faculty position as an Assistant Scientist in the department of Epidemiology at the Johns Hopkins University Bloomberg School of Public Health (Hopkins). Dr. Anderson's research interests center around nutrition as a means to prevent cardiovascular disease (CVD) in minority and underserved populations. Her long-term goal is to combine her interdisciplinary training in health behavior, epidemiology and nutritional sciences to conduct observational and clinical studies of CVD. In this application, Dr. Anderson outlines a career development and research plan that provides critical new scientific skills and extend her research capabilities, to enhance her development into an independent scientist. Lawrence Appel, MD, MPH will mentor Dr. Anderson in the proposed research. Dr. Appel is a recognized expert in CVD prevention through both pharmacologic and non-pharmacologic (diet) approaches. He is a professor of medicine, epidemiology and international health (nutrition) at the Johns Hopkins Medical Institutions. Dr. Anderson has also assembled an advisory committee of accomplished researchers to provide scientific and career development advice, as well as evaluate her progress. The objectives of Dr. Anderson's research plan are to examine the main and interactive effects of dietary sodium and potassium intake (measured by 24-hour urinary excretion) on echocardiographic left ventricular (LV) mass and clinical CVD. Her research will be conducted within the context of the NIH-funded African American Study of Kidney Disease and Hypertension (AASK) study. She will use do secondary analyses of data from both the AASK trial and AASK cohort study. The ongoing AASK cohort study is a prospective, observational study that is an extension of the AASK trial which tested the effects of three anti-hypertensive therapies and two levels of blood pressure control on progression of kidney disease. Dr. Anderson will also conduct additional (de-novo) data collection, in a subcohort of AASK, to characterize the sources of dietary sodium and potassium in the cohort - a highly relevant clinical issue. Dr. Anderson is in a supportive institutional environment at Hopkins that maximizes her potential to establish an independent, competitive research agenga that will support a prolific academic career. (End of Abstract)

描述（由申请人提供）： 这是谢丽尔·安德森 (Cheryl Anderson) 博士申请 NHLBI 指导职业发展奖以促进生物医学研究教师多样性 (K01)。 Cheryl Anderson 博士、公共卫生硕士是一位营养流行病学家，并在约翰霍普金斯大学布隆伯格公共卫生学院（霍普金斯）流行病学系担任助理科学家。安德森博士的研究兴趣集中在将营养作为预防少数民族和服务不足人群心血管疾病 (CVD) 的一种手段。她的长期目标是将她在健康行为、流行病学和营养科学方面的跨学科培训结合起来，进行心血管疾病的观察和临床研究。在此申请中，安德森博士概述了职业发展和研究计划，该计划提供关键的新科学技能并扩展她的研究能力，以促进她发展成为一名独立科学家。 Lawrence Appel（医学博士、公共卫生硕士）将在拟议的研究中指导安德森博士。 Appel 博士是通过药物和非药物（饮食）方法预防 CVD 的公认专家。他是约翰霍普金斯大学医疗机构的医学、流行病学和国际卫生（营养）教授。安德森博士还组建了一个由杰出研究人员组成的咨询委员会，提供科学和职业发展建议，并评估她的进展。安德森博士的研究计划的目标是检查膳食钠和钾摄入量（通过 24 小时尿液排泄测量）对超声心动图左心室 (LV) 质量和临床 CVD 的主要影响和交互影响。她的研究将在美国国立卫生研究院资助的非裔美国人肾脏疾病和高血压研究 (AASK) 的背景下进行。她将使用 AASK 试验和 AASK 队列研究的数据进行二次分析。正在进行的 AASK 队列研究是一项前瞻性观察性研究，是 AASK 试验的延伸，该试验测试了三种抗高血压疗法和两种血压控制水平对肾脏疾病进展的影响。安德森博士还将在 AASK 的一个子队列中进行额外的（从头）数据收集，以描述该队列中膳食钠和钾的来源——这是一个高度相关的临床问题。安德森博士在霍普金斯大学的支持性机构环境中，最大限度地发挥了她的潜力，建立了一个独立的、有竞争力的研究议程，以支持多产的学术生涯。 （摘要完）