Administrative Core

行政核心

• 批准号: 10663222
• 负责人: SUZANNE CRAFT
• 金额: $ 38.68万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663222
• 关键词: Achievement; Action Research; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Animal Welfare; Area; Award; Blood Vessels; Clinical; Clinical Sciences; Collaborations; Communities; Consultations; Creativeness; Data; Dementia; Development; Education; Ensure; Ethics; Feedback; Fostering; Goals; Growth; Infrastructure; Institution; Interdisciplinary Education; Interdisciplinary Study; Lead; Leadership; Metabolic; Mission; Nature; Participant; Performance; Phenotype; Policies; Process; Program Evaluation; Regulation; Research; Research Personnel; Resources; Risk; Role; Series; Services; Specimen; Translational Research; Universities; Vision; Work; career; data management; disease heterogeneity; forest; health disparity; human subject; imaging biomarker; innovation; member; model design; neuropathology; normal aging; novel; programs; repository; success; translational model; translational scientist; trial design; vascular factor

Administrative Core – Project Summary The Wake Forest Alzheimer’s Disease Research Center (WF ADRC) provides a comprehensive, integrated infrastructure to facilitate research aimed at identifying the causes of AD, and elucidating the role of vascular/metabolic factors in transitions from normal aging to AD and other dementias. The WF ADRC also provides resources to better understand disease heterogeneity and the multi-faceted impact of health disparities on AD risk. The Administrative Core ensures that ADRC scientific and programmatic goals are achieved by providing visionary oversight and effective governance to all Center activities, and scientific direction to the Center as a whole. The Core will be directed by an Executive Committee, whose members include the Director, Associate Directors, Core and Service Leaders, and the Program Manager. The Executive Committee will be guided by an Internal Advisory Committee (IAC) composed of institutional leaders who meet regularly to facilitate the achievement of ADRC aims and promote the growth of AD research at WF. The Core will be also guided by an External Advisory Committee (EAC), chosen in consultation with the NIA and consisting of members of other ADRCs and scientific leaders. The EAC will meet annually to review WF ADRC program goals and progress. We will also seek input about ADRC engagement with our community and participants through our Community and Participant Advisory Boards. Expansion of AD-related research and impactful utilization of valuable scientific resources are important goals for all ADRCs. The Administrative Core Committee for Resource Utilization and Research EXpansion (CRUX) oversees a coordinated series of activities to ensure that ADRC resources contribute to high-impact research and that new translational scientists are brought into the field. In the past cycle, the CRUX facilitated the rapid and successful integration of our new ADRC into the larger ADRC network, providing data and biospecimen resources to the National Alzheimer’s Coordinating Center (NACC), the National Centralized Repository for AD (NCRAD), other ADRCs and AD investigators world-wide. Through its distinctive theme and innovative phenotyping, our ADRC contributes to National Alzheimer’s Project Act (NAPA) Research Milestones involving metabolic/vascular factors, health disparities, translational models and trial design. WF ADRC’s ability to achieve its scientific and educational mission depends on the efficacy of its Administrative Core. In its inaugural cycle, Core leaders developed and led vigorous interdisciplinary research and educational programs. We have established effective Executive and Internal Advisory Committees, launched a successful pilot program that has drawn creative new investigators to AD research, and established multiple high-impact collaborations. Our comprehensive activities to date demonstrate that Administrative Core members have the vision, influence, and commitment to ensure the far-reaching success of the WF ADRC.

行政核心 – 项目摘要 维克森林阿尔茨海默病研究中心 (WF ADRC) 提供全面、综合的研究 基础设施，以促进旨在确定 AD 原因并阐明 AD 作用的研究 从正常衰老到 AD 和其他痴呆症的转变中的血管/代谢因素 WF ADRC 也。 提供资源以更好地了解疾病异质性和健康的多方面影响 行政核心确保 ADRC 的科学和计划目标是一致的。 通过对中心的所有活动提供有远见的监督和有效的治理以及科学的 整个中心的方向将由执行委员会指导，其成员包括： 包括总监、副总监、核心和服务领导以及项目经理。 执行委员会将接受内部咨询委员会（IAC）的指导，该委员会由机构组成 领导人定期会面以促进 ADRC 目标的实现并促进 AD 的发展 WF 的研究也将受到外部咨询委员会 (EAC) 的指导。 EAC 将与 NIA 进行磋商，并由其他 ADRC 成员和科学领袖组成。 每年举行一次会议，审查 WF ADRC 计划的目标和进展情况。我们还将征求有关 ADRC 的意见。 通过我们的社区和参与者咨询委员会与我们的社区和参与者互动。 扩大 AD 相关研究和有效利用宝贵的科学资源非常重要 所有 ADRC 的目标 资源利用和研究扩展行政核心委员会。 (CRUX) 监督一系列协调一致的活动，以确保 ADRC 资源有助于产生高影响力 在过去的周期中，CRUX 促进了研究和新的转化科学家进入该领域。 我们的新 ADRC 快速成功地集成到更大的 ADRC 网络中，提供数据和 生物样本资源提供给国家阿尔茨海默病协调中心 (NACC) AD 知识库 (NCRAD)、全球其他 ADRC 和 AD 调查人员通过其独特的主题和 创新表型分析，我们的 ADRC 为国家阿尔茨海默病项目法案 (NAPA) 研究做出贡献 涉及代谢/血管因素、健康差异、转化模型和试验设计的里程碑。 WF ADRC 实现其科学和教育使命的能力取决于其 行政核心。在其首个周期中，核心领导者开发并领导了积极的跨学科研究。 我们建立了有效的执行和内部咨询委员会， 启动了一项成功的试点计划，吸引了富有创造力的新研究者参与 AD 研究，并建立了 迄今为止，我们的多项高影响力合作表明了行政核心。 成员拥有远见、影响力和承诺，可确保 WF ADRC 取得深远的成功。