Comprehensive NAU/AZCC Cancer Research Partnership

NAU/AZCC 癌症研究综合合作伙伴关系

• 批准号: 7691872
• 负责人: Diane M Stearns
• 金额: $ 20万
• 依托单位: NORTHERN ARIZONA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-20 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7691872
• 关键词: Address; American Indians; Arizona; Basic Science; Cancer Center; Chemicals; Clinical Trials; Collaborations; Communities; Community Outreach; Data; Development; Education and Outreach; Effectiveness; Face; Faculty; Future; Health Personnel; Healthcare; Industry; Institution; Link; Malignant Neoplasms; Mining; NCI Center for Cancer Research; Native Americans; Oncologist; Patients; Pilot Projects; Provider; Rate; Recording of previous events; Recruitment Activity; Research; Research Activity; Research Personnel; Reservations; Students; Training; Training Programs; Universities; anticancer research; cancer diagnosis; cancer education; career; improved; interest; mortality; programs

DESCRIPTION: (Applicant?s Description) In the face of improved US cancer survival, cancer mortality in American Indians is increasing. Cultural differences make addressing this disparity challenging. The paucity of American Indian health care providers, almost none oncologists, compounds the situation. American Indian patients, unable to effectively communicate with providers, become isolated from cancer diagnosis and treatment and are rarely recruited into clinical trials. While the need for American Indian oncologists is therefore urgent, few American Indians enter health care professions. While most universities have dismal recruitment and retention rates, Northern Arizona University (NAU) has a distinguished history of graduating Native American students. At NAU, however, there is no cancer research core to provide cancer education to American Indian students and communities. In this partnership, we will link research programs of the Arizona Cancer Center (AZCC) with American Indian student training programs and environmental research at NAU. While informal faculty interaction exists, there is currently no comprehensive plan to enhance cancer research at NAU or to coordinate American Indian student recruitment and retention at NAU and UofA/AZCC. The objectives of this proposal are to (1)initiate robust cancer research at NAU to enhance faculty career development and train students in cancer research fundamentals; (2) create stable, long-term cancer research, education, and outreach collaboration; and (3) improve institutional effectiveness in impacting the disparity in cancer in American Indians of the Southwest. Research programs will focus on the carcinogenic effects of chemicals associated with the mining industry on reservations. American Indian students have a vital interest in the data. Thus this vested interest greatly enhances our potential to recruit and retain these students and to provide future American Indian cancer researchers and oncologists. The program is guided by administrative, planning and developmental cores at each institution. Research activities include basic science, cancer education, and community outreach components. We propose 6 pilot projects, 4 full projects, and recruitment of 2 new faculty over the project lifetime.

描述：（申请人的描述）面对美国癌症的改善 生存，美洲印第安人的癌症死亡率正在增加。文化 差异使得解决这种差异挑战。很少 美洲印第安人医疗保健提供者，几乎没有肿瘤学家，使 情况。美洲印第安人，无法有效沟通 提供者，与癌症诊断和治疗隔离，很少是 招募到临床试验中。而对美洲印第安人的需求 因此，肿瘤学家很紧急，很少有美国印第安人进入医疗保健 专业。虽然大多数大学都有惨淡的招募和保留 费率，北亚利桑那大学（NAU）有着杰出的历史 即将毕业的美国原住民学生。但是，在NAU，没有癌症 研究核心向美洲印第安学生提供癌症教育，并 社区。在这种伙伴关系中，我们将链接 亚利桑那癌症中心（AZCC）与美洲印第安学生培训计划 和NAU的环境研究。尽管存在非正式的教师互动，但目前尚无综合计划来加强NAU或 协调美洲印第安学生在NAU的招聘和保留率， UOFA/AZCC。该提案的目标是（1）启动鲁棒性癌症 NAU的研究以增强教师职业发展并培训学生 癌症研究基础； （2）创建稳定的长期癌症研究， 教育和宣传合作； （3）改善机构 影响美国印第安人癌症差异的有效性 西南。研究计划将重点介绍 与采矿业相关的化学物质在保留方面。美国人 印度学生对数据具有重要的兴趣。因此这个既得利益 极大地增强了我们招募和保留这些学生的潜力 提供未来的美洲印第安癌症研究人员和肿瘤学家。这 计划在每个方面都以行政，规划和发展核心为指导 机构。研究活动包括基础科学，癌症教育和 社区外展组件。我们建议6个试点项目，4个完整项目， 并在项目寿命中招募了2个新教师。

项目成果

FlgM proteins from different bacteria exhibit different structural characteristics.

• DOI: 10.1016/j.bbapap.2013.01.010
• 发表时间: 2013-04
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
• 影响因子: 3.2
• 作者: Ma, Wai Kit;Hendrix, Rachel;Stewart, Claire;Campbell, Eric V.;Lavarias, Mitchell;Morris, Kolyn;Nichol, Shauna;Gage, Matthew J.
• 通讯作者: Gage, Matthew J.

Photoactivated uranyl ion produces single strand breaks in plasmid DNA.

• DOI: 10.1021/tx200410x
• 发表时间: 2011-11-21
• 期刊: Chemical research in toxicology
• 影响因子: 4.1
• 作者: George SA;Whittaker AM;Stearns DM
• 通讯作者: Stearns DM

Characterization of PM(2.5) collected during broadcast and slash-pile prescribed burns of predominately ponderosa pine forests in northern Arizona.

• DOI: 10.1016/j.atmosenv.2011.01.051
• 发表时间: 2011-04
• 期刊: ATMOSPHERIC ENVIRONMENT
• 影响因子: 5
• 作者: Robinson, Mann S.;Zhao, Min;Zack, Lindsay;Brindley, Christine;Portz, Lillian;Quarterman, Matthew;Long, Xiufen;Herckes, Pierre
• 通讯作者: Herckes, Pierre

Conformational detection of p53's oligomeric state by FlAsH Fluorescence.

通过 FlaAsH 荧光对 p53 寡聚状态进行构象检测。

• DOI: 10.1016/j.bbrc.2009.04.073
• 发表时间: 2009
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Webber,TawnyaM;Allen,AndrewC;Ma,WaiKit;Molloy,RhettG;Kettelkamp,CharisseN;Dow,CaitlinA;Gage,MatthewJ
• 通讯作者: Gage,MatthewJ

Toxicity of depleted uranium complexes is independent of p53 activity.

• DOI: 10.1016/j.jinorgbio.2010.10.010
• 发表时间: 2011-02
• 期刊: JOURNAL OF INORGANIC BIOCHEMISTRY
• 影响因子: 3.9
• 作者: Heintze, Ellie;Aguilera, Camille;Davis, Malia;Fricker, Avery;Li, Qiang;Martinez, Jesse;Gage, Matthew J.
• 通讯作者: Gage, Matthew J.