Improving Brain-Behavior Markers of Preschool Executive Function through aGroup-Based Parenting Intervention for Low-Income Families

通过针对低收入家庭的团体育儿干预改善学前执行功能的大脑行为标志

• 批准号: 10663529
• 负责人: Jennifer Suor
• 金额: $ 20.21万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663529
• 关键词: 5 year old; Address; Adolescence; Aftercare; Age; Area; Award; Behavior; Behavioral; Behavioral Mechanisms; Brain; Caregivers; Chicago; Child; Child Rearing; Childhood; Chronic; Clinical Trials; Community Mental Health Services; Conduct Disorder; Control Groups; Data; Development; Diagnostic; Discipline; Disruptive Behavior Disorder; Electroencephalography; Eligibility Determination; Enrollment; Ensure; Etiology; Evaluation; Executive Dysfunction; Family; Goals; Health Services Research; Illinois; Impairment; Individual Differences; Influentials; Informal Social Control; Intervention; Interview; Investigational Therapies; Knowledge; Link; Longevity; Low income; Measures; Mediating; Medicaid eligibility; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modification; Monitor; National Institute of Mental Health; Neuronal Plasticity; Nursery Schools; Oppositional Defiant Disorder; Parents; Phase; Poverty; Prediction of Response to Therapy; Prevention program; Problem behavior; Psychiatry; Psychopathology; Publishing; Randomized; Recording of previous events; Reporting; Research; Research Domain Criteria; Risk; Sampling; Scientist; Stress; Surveys; Testing; Time; Training; Universities; Work; Youth; affective neuroscience; brain behavior; career; career development; clinical translation; cognitive control; cognitive performance; cognitive process; cognitive task; collaborative environment; community based research; comparison control; cost efficient; design; diagnostic criteria; dissemination science; early childhood; executive function; experience; follow-up; health disparity; implementation science; improved; indexing; lower income families; neural; neurophysiology; novel; parental influence; prevent; preventive intervention; programs; protective effect; psychosocial; randomized, clinical trials; recruit; scaffold; skills; theories; therapeutic target

PROJECT ABSTRACT Impairments in executive functioning (EF), cognitive processes that support self-regulation, disproportionately impact children living in poverty and increase vulnerability for childhood disruptive behavior disorders (DBDs; oppositional defiant disorder, conduct disorder), which trigger a cascade of mental health problems and psychosocial difficulties across the lifespan. Poverty-related stress and maladaptive parenting styles have been linked to alterations of neural and behavioral EF markers in children; despite this, no studies have studied if parenting prevention programs can directly target childhood EF, and through improving EF, reduce disruptive behaviors in at-risk children. This K23 Mentored Patient-Oriented Research Career Development Award application seeks to conduct a mechanistic randomized clinical trial to determine whether neural-behavioral indices of childhood EF is an experimental therapeutic target that can be modified via caregiver participation in the Chicago Parent Program (CPP; Aim 1). Consistent with the NIMH Research Domain Criteria framework, childhood EF will be assessed across multiple levels of analysis (electroencephalogram [EEG], behavior, survey). The project also seeks to evaluate whether increases in childhood neural-behavioral EF mediate the effects of CPP in reducing disruptive behavior problems over a short-term follow-up (Aim 2). The project will also explore whether increases in specific parenting practices (discipline, scaffolding), previously linked to individual differences in EF, mediate the effects of CPP in predicting change in childhood neural-behavioral EF (Aim 3). The sample will include 90 Medicaid eligible parent-child (ages 4-5 years old) dyads; and will employ a novel recruitment approach where the target child will have moderate-to-severe EF delays at baseline but does not meet diagnostic criteria for a DBD. Consistent with the candidate's translational clinical scientist career goals, the candidate seeks crucial training in: community-based research and dissemination and implementation science, advanced EEG methods to evaluate neural-behavioral EF targets of preventive interventions, and statistical skills to design and evaluate clinical trials. Training will occur in an outstanding interdisciplinary environment at the University of Illinois at Chicago, in the Department of Psychiatry and leverage the department's established strengths in community mental health services research, dissemination and implementation science, and affective neuroscience. Mentors Drs. Atkins, Fitzgerald and Bhaumik and consultants Drs. Klumpp, Wakschlag, Gross, and Handley have expertise in the training areas and extensive histories of early career mentorship, and will work together to ensure the candidate's successful transition to research independence. Study findings will support an R01 application to validate the results on a larger scale and launch the candidate's academic career as a preventive intervention scientist. Findings have significant potential to identify whether CPP, a cost-efficient parenting intervention, modifies neural-behavioral EF indices in urban poor children, a theorized etiological risk mechanism of DBDs, and therefore prevent DBDs.

项目摘要 执行功能（EF）、支持自我调节的认知过程严重受损 影响生活贫困的儿童并增加儿童破坏性行为障碍（DBD； 对立违抗性障碍（品行障碍），引发一系列心理健康问题 整个生命周期的心理社会困难。与贫困有关的压力和不适应的养育方式已经 与儿童神经和行为 EF 标记物的改变有关；尽管如此，还没有研究研究过 如果育儿预防计划可以直接针对儿童 EF，并通过改善 EF，减少破坏性的 高危儿童的行为。 K23 指导的以患者为中心的研究职业发展奖 该申请旨在进行机械随机临床试验，以确定神经行为是否 儿童 EF 指数是一个实验性治疗目标，可以通过护理人员的参与进行修改 芝加哥家长计划（CPP；目标 1）。与 NIMH 研究领域标准框架一致， 儿童 EF 将通过多个层面的分析进行评估（脑电图 [EEG]、行为、 民意调查）。该项目还试图评估儿童神经行为 EF 的增加是否会介导 CPP 在短期随访中减少破坏性行为问题的效果（目标 2）。该项目将 还探讨了特定的养育做法（纪律、脚手架）的增加是否与先前有关 EF 的个体差异介导 CPP 在预测儿童神经行为 EF 变化中的作用 （目标 3）。样本将包括 90 名符合医疗补助资格的亲子（4-5 岁）二人组；并将聘用一名 新颖的招募方法，目标儿童在基线时会有中度至重度的 EF 延迟，但不会 不符合 DBD 的诊断标准。与候选人的转化临床科学家职业生涯一致 目标，候选人寻求以下方面的重要培训：基于社区的研究和传播以及 实施科学、先进的脑电图方法来评估预防性的神经行为 EF 目标 设计和评估临床试验的干预措施和统计技能。培训将以出色的方式进行 伊利诺伊大学芝加哥分校精神病学系的跨学科环境 利用该部门在社区精神卫生服务研究、传播方面的既定优势 和实施科学，以及情感神经科学。导师博士。阿特金斯、菲茨杰拉德和鲍米克 顾问博士。 Klumpp、Wakschlag、Gross 和 Handley 拥有培训领域的专业知识和广泛的知识。 早期职业指导的历史，并将共同努力确保候选人成功过渡到 研究独立性。研究结果将支持 R01 应用以更大规模地验证结果 并开启候选人作为预防干预科学家的学术生涯。调查结果具有重大意义 确定 CPP（一种具有成本效益的育儿干预措施）是否可以改变神经行为 EF 指数的潜力 在城市贫困儿童中，建立了 DBD 的理论病因风险机制，从而预防 DBD。