Project 2 - Mindfulness & Stress Arousal

项目 2 - 正念

基本信息

批准号：
7655421
负责人：
Susan Folkman
金额：
$ 29.49万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7655421
关键词：
Acute Affect Affective Arousal Attention Autonomic nervous system Biological Assay Blood Vessels CD4 Positive T Lymphocytes Cardiac Cell Count Cells Clinical Trials Cognitive Compatible Control Groups Daily Data Disease Progression Exposure to Figs - dietary Goals HIV HIV Infections Heart Rate Hormones Immune system Individual Intervention Laboratories Life Link Mediating Mediation Meditation Mental Depression Neurosecretory Systems Participant Pathway interactions Pattern Perception Persons Physiological Principal Investigator Process Recovery Regulation Resources Role Self Efficacy Shapes Staging Stress Stress and Coping T-Lymphocyte Testing Theoretical model Trier Social Stress Test Upper arm Viral Load result Waiting Lists Work antiretroviral therapy base biological adaptation to stress coping mindfulness-based stress reduction programs psychologic response stressor theories

项目摘要

Project 2, Mindfulness and Stress Arousal, extends the work of Project 1, the clinical trial of Mindfulness Based Stress Reduction (MBSR), by examining specific stress-related adaptive and maladaptive cognitive and affective mechanisms through which MBSR may influence neuroendocrine and autonomic nervous system activity. The hypotheses are based on Stress and Coping Theory (Lazarus & Folkman, 1984), which emphasizes the role of cognitive appraisal in shaping the psychological and physiological stress response. This framework is compatible with the principles of the MBSR program, which highlight the regulation of attention and perception as a way to reduce stress. Project 2 includes two studies. Study A will test hypotheses regarding the relationship between perceived stress and basal neuroendocrine activity (Specific Aim 1) and the extent to which the effects of MBSR on basal neuroendocrine activity are mediated by adaptive and maladaptive cognitive and affective pathways (Specific Aim 2). Subjects will include all the participants in the MBSR arm of Project 1 (N = 165) and participants in the wait-list control group (N=83). Psychological assessments will be made at baseline, post intervention, 6 months, and 12 months. Diurnal catabolic and anabolic hormones will be assayed at baseline, post intervention, and 12 months. In Study B, these same hypotheses will be tested in a controlled laboratory setting where participants will be exposed to an acute laboratory stressor (Trier Social Stress Test) post-intervention, while autonomic reactivity is assessed in additon to neuroendocrine reactivity (Specific Aim 3). The primary goal of Study B is to test whether people who take MBSR respond with a more adaptive physiological profile. Appraisal processes, and their attendant patterns of affective and physiological arousal, have also been linked to HIV disease progression. In Specific Aim 4, the relationship between adaptive and maladaptive arousal responses will be examined in relation to CD4+ T cell decline, HIV viral load, and depression. Project 2 will also provide data for Project 3 with which it can further explore the links between neuroendocrine response to both naturalistic and laboratory stress and immune system mediation.

项目2，正念和压力唤醒，扩展了项目1的工作，即基于正念的压力减轻（MBSR）的临床试验（MBSR），通过检查特定的与压力相关的适应性和适应性的认知和情感机制，MBSR可能会影响神经内分泌和自治神经系统活动。这些假设基于压力和应对理论（Lazarus＆Folkman，1984），该理论强调了认知评估在塑造心理和生理压力反应中的作用。该框架与MBSR计划的原理兼容，该框架强调了注意力和感知的调节，以减轻压力。项目2包括两项研究。研究A遗嘱测试关于感知到的压力与基础神经内分泌活性之间关系的假设（特定目标1）以及MBSR对基础神经内分泌活性的影响的程度是由适应性和适应性认知和情感途径（特定目标2）介导的。受试者将包括项目1的MBSR组中的所有参与者（n = 165）和等待名单对照组的参与者（n = 83）。心理评估将在基线，干预后，6个月和12个月进行。昼夜分解代谢和合成代谢激素将在基线，干预后和12个月进行测定。在研究B中，这些相同的假设将在受控的实验室环境中进行检验干预后，急性实验室压力源（TRIER社会压力测试），而自主反应性则是对神经内分泌反应性的Additon中评估的（特定目标3）。研究B的主要目标是测试服用MBSR的人是否以更适应性的生理形象做出反应。评估过程及其情感和生理唤醒的随之而来的模式也与HIV疾病进展有关。在特定的目标4中，将检查适应性和适应不良的唤醒反应之间的关系，以与CD4+ T细胞下降，HIV病毒载量和抑郁症有关。项目2还将提供项目3的数据，它可以进一步探讨神经内分泌反应与自然主义和实验室压力与免疫系统调解之间的联系。