Pain in Hidradenitis Suppurativa: Phenotypes and Stakeholder Perspectives

化脓性汗腺炎的疼痛：表型和利益相关者的观点

基本信息

批准号：
10661836
负责人：
Lauren Anne Vigil Orenstein
金额：
$ 15.09万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-08 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10661836
关键词：
18 year old Abscess Absence of pain sensation Address Adult Advocate Affect African American population Analgesics Anxiety Applications Grants Behavioral Biometry Capital Caring Central Nervous System Chronic Cicatrix Classification Clinical Clinical Trials Communities Complex Data Dermatologic Dermatology Development Plans Disease Doctor of Philosophy Enrollment Environment Epidemiology Evaluation Frequencies Functional disorder Health Services Research Health system Heart Rate Heart failure Hidradenitis Suppurativa Impairment Inflammation Institution International Intervention Interview K-Series Research Career Programs Linear Regressions Measurement Measures Mental Depression Mentors Methods Mission Mood Disorders National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Needs Assessment Nerve Neuropathy Nociception Numeric Rating Scale Outcome Outcomes Research Pain Pain Measurement Pain interference Pain management Pain quality Palliative Care Participant Patient Outcomes Assessments Patients Pattern Persistent pain Phenotype Prevalence Prognosis Prospective Studies Prospective, cohort study Quality of life Recommendation Recurrence Research Research Design Research Personnel Resources Role Safety Sampling Sensory Severities Statistical Data Interpretation Stimulus Structure Surveys Symptoms Techniques Testing Time Training Validation Woman Work care preference career career development chronic inflammatory skin daily functioning daily pain design effective therapy experience improved improved outcome intervention mapping medical schools medical specialties multidisciplinary multimodality opioid use pain outcome pain reduction painful neuropathy patient oriented personalized medicine pharmacologic preference professor recruit research and development skills skin disorder social somatosensory stakeholder perspectives suicidal risk systemic inflammatory response therapy development tissue injury treatment response

项目摘要

PROJECT SUMMARY/ABSTRACT Candidate: This K23 career development award will prepare Lauren Orenstein, MD MS to understand pain mechanisms and trajectories in hidradenitis suppurativa (HS) in order to develop and evaluate targeted interventions that reduce pain and improve quality of life (QoL) in serious skin diseases. Through this K23, she will pursue three career development objectives: (1) develop expertise in the conduct and statistical analysis of prospective studies, (2) obtain skills in mixed methods, and (3) gain practical experience in stakeholder engaged research for intervention development and evaluation. Mentoring and Environment: Dr. Orenstein has assembled an internationally renowned mentor team with complementary expertise and an outstanding track record of mentoring junior investigators. Her primary mentors are: Rachel Patzer, PhD MPH (expertise: prospective study design, statistical techniques, outcome validation, health services research) and Dio Kavalieratos, PhD (expertise: mixed methods, stakeholder-engaged research, design and evaluation of complex behavioral and health systems interventions). Her co-mentors are: Suephy Chen, MD MS (patient-reported outcomes in skin disease), Amit Garg, MD (HS epidemiology and outcome metrics) and Daniel Harper, PhD (pain mechanisms and quantitative sensory testing). Consultants include: John Ingram, MA MSc DM FRCP FAcadMedEd (pain measurement in HS), Kimberly Curseen, MD (palliative care), Anne-Marie McKenzie-Brown, MD (pain management), and Dong Li MD, MD PhD (biostatistics). As an Assistant Professor of Dermatology, Dr. Orenstein will have access to the Dermatology Center for Outcomes Research and Safety unit and the resources and institutional capital of Emory School of Medicine. Research: HS is a chronic inflammatory skin disease affecting ~0.4% of adults that causes recurrent, painful scarring abscesses leading to poor QoL. Pain is rated by HS patients as their most important symptom, yet little is known about its mechanisms, trajectory, best practices for measuring HS pain, or effective treatments. Specific Aims: In a prospective cohort study, we will identify HS pain mechanisms, determine the influence of pain mechanisms on pain interference with daily activities, establish HS pain trajectory patterns, and optimize HS pain measurement for clinical trials. In a separate study, we will use a mixed methods design to understand domains of suffering, unmet pain needs, and pain care preferences in HS patients and their care partners. We will present these data to a stakeholder panel consisting of HS patients, community advocates, and clinical experts who will use Intervention Mapping techniques to generate recommendations for designing and evaluating complex intervention(s) that reduce pain in HS. The proposed research will provide Dr. Orenstein with the preliminary data and training to apply for an R01 focused on HS pain mechanisms and an R21 and subsequent R01 to develop, pilot, and evaluate complex interventions to mitigate pain and suffering in HS.

项目概要/摘要候选人：K23 职业发展奖将使 Lauren Orenstein（医学博士、硕士）了解化脓性汗腺炎 (HS) 的疼痛机制和轨迹，以便开发和评估有针对性的干预措施，可减轻严重皮肤病的疼痛并提高生活质量 (QoL)。通过在此K23中，她将追求三个职业发展目标：（1）培养行为方面的专业知识和前瞻性研究的统计分析，（2）获得混合方法的技能，（3）获得实践利益相关者参与干预措施开发和评估研究的经验。指导与环境：奥伦斯坦博士召集了一位国际知名的导师团队具有互补的专业知识和指导初级研究人员的出色记录。她的主要导师是：Rachel Patzer，PhD MPH（专业知识：前瞻性研究设计、统计技术、结果验证、卫生服务研究）和 Dio Kavalieratos 博士（专业知识：混合方法、利益相关者参与的复杂行为和行为的研究、设计和评估卫生系统干预措施）。她的共同导师是：Suephy Chen，MD MS（患者报告的结果皮肤病），Amit Garg 医学博士（HS 流行病学和结果指标）和 Daniel Harper 博士（疼痛机制和定量感觉测试）。顾问包括：John Ingram，文学硕士、理学硕士 FRCP FAcadMedEd（HS 疼痛测量）、Kimberly Curseen，医学博士（姑息治疗）、Anne-Marie McKenzie-Brown 医学博士（疼痛管理）和李东医学博士、医学博士博士（生物统计学）。作为助理皮肤病学教授奥伦斯坦博士将有权进入皮肤病学结果中心研究和安全部门以及埃默里医学院的资源和机构资本。研究：HS 是一种慢性炎症性皮肤病，影响约 0.4% 的成年人，导致复发性疼痛疤痕脓肿导致生活质量差。热射病患者将疼痛视为最重要的症状，但人们对其机制、轨迹、测量 HS 疼痛的最佳实践或有效治疗知之甚少。具体目标：在一项前瞻性队列研究中，我们将确定 HS 疼痛机制，确定以下因素的影响：疼痛干扰日常活动的疼痛机制，建立HS疼痛轨迹模式，并优化用于临床试验的 HS 疼痛测量。在一项单独的研究中，我们将使用混合方法设计来理解 HS 患者及其护理伙伴的痛苦领域、未满足的疼痛需求和疼痛护理偏好。我们将向由 HS 患者、社区倡导者和临床人员组成的利益相关者小组提供这些数据专家将使用干预图技术来生成设计和建议评估可减轻 HS 疼痛的复杂干预措施。拟议的研究将为奥伦斯坦博士提供有了初步数据和培训，可以申请专注于 HS 疼痛机制的 R01 和 R21 以及随后的 R01 旨在开发、试点和评估复杂的干预措施，以减轻 HS 的疼痛和痛苦。