Sleep and Metabolism in Obesity: Impact of Gender

睡眠和肥胖对新陈代谢的影响：性别的影响

• 批准号: 7678041
• 负责人: DAVID A EHRMANN
• 金额: $ 30.19万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7678041
• 关键词: Accounting; Address; Adipocytes; Adrenal Gland Hyperfunction; Adult; Adverse effects; Affect; Aftercare; Age; Aging; American; Beta Cell; Biopsy; Blood Pressure; Body fat; Brain; C-reactive protein; Cardiac; Cardiovascular system; Catecholamines; Characteristics; Chronic; Clinical; Communities; Condition; Continuous Positive Airway Pressure; Cushing Syndrome; Data; Data Set; Depth; Development; Diagnostic; Disease; Dyslipidemias; Electroencephalography; Elevation; Enrollment; Equilibrium; Fatty acid glycerol esters; Frequencies; Functional disorder; Gender; Glucocorticoids; Glucose; Goals; Gonadal Steroid Hormones; Health; Healthcare; Hepatic; Hydrocortisone; Hypertension; Hypoxia; Individual; Individual Differences; Inflammatory; Inpatients; Insulin Resistance; Interdisciplinary Study; Lead; Link; Lipids; Magnetic Resonance Imaging; Measures; Mental Depression; Metabolic; Metabolic syndrome; Metabolism; Non obese; Numbers; Obesity; Obstructive Sleep Apnea; Outcome; Output; Overweight; Pituitary-Adrenal System; Plasma; Play; Polysomnography; Premenopause; Prevalence; Prevention; Principal Investigator; Procedures; Protocols documentation; REM Sleep; Range; Recurrence; Regulation; Risk Factors; Role; Screening procedure; Sex Characteristics; Sleep; Sleep Apnea Syndromes; Sleep Fragmentations; Sleep Stages; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; Somatotropin; Study Subject; Testing; Therapeutic; Time; Today; Triglycerides; Woman; Work; adipokines; base; cardiovascular risk factor; cytokine; day; diabetes risk; glucose tolerance; improved; indexing; insight; insulin sensitivity; intravenous glucose tolerance test; men; non rapid eye movement; non-diabetic; programs; respiratory; sex; sleep regulation; subcutaneous; trait

Obesity is a major risk factor for obstructive sleep apnea (OSA), a condition characterized by repetitive respiratory disturbances, intermittent hypoxia, sleep fragmentation by frequent microarousals and low amounts of deep slow wave sleep [SWS]). Today, more than 10 million American women suffer from OSA. OSA has been identified as an independent risk factor for the metabolic syndrome. Because OSA is more prevalent in men than in women, a disproportionate number of studies of OSA and its consequences have been conducted in men. Thus, OSA has been characterized as a disorder associated with gender-based health care inequity. Recent evidence, including data from our group, suggests that reduced amounts and intensity of SWS (i.e.slow-wave activity [SWA]) may play a pivotal role in the development of metabolic and cardiovascular disturbances in obese men and women, particularly those with OSA. The present project will focus on sex differences in SWA and their relationship with daytime sleepiness and metabolic vulnerability in obese men and women with and without OSA. We propose to simultaneously characterize: 1. sleep-wake regulation; 2. measures of diabetes risk 3. measures of cardiovascular risk and 4. profiles of sex steroids, cortisol and adipokines in a. obese men without OSA, b. obese men with OSA before and after treatment with continuous positive airway pressure (CPAP), c. obese pre-menopausal women without OSA, and d. obese pre-menopausal women with OSA before and after CPAP treatment. The completion of these interdisciplinary studies will provide a unique data set contrasting in obese women versus obese men the relationships between sleep and the metabolic syndrome, OSA and the metabolic syndrome and the impact of CPAP treatment on the metabolic syndrome. The proposed work will provide important insights regarding the pathophysiology of OSA and its adverse consequences in obese men and women, and the basis for the development of effective sex-specific prevention and treatment strategies.

肥胖是阻塞性睡眠呼吸暂停（OSA）的主要危险因素，这种疾病以重复性为特征 呼吸障碍，间歇性缺氧，频繁微观的睡眠破碎和低 深度慢波睡眠量[SWS]）。如今，超过1000万美国妇女患有OSA。 OSA已被确定为代谢综合征的独立危险因素。因为OSA更多 男性的普遍比女性普遍，OSA及其后果的数量不成比例 是在男人中进行的。因此，OSA被描述为与基于性别的疾病 医疗保健不平等。最近的证据，包括来自我们小组的数据，表明数量减少和 SWS的强度（即Slow-Wave活动[SWA]）可能在代谢和代谢的发展中起关键作用 肥胖的男人和女性，尤其是患有OSA的男女心血管疾病。本项目将 专注于SWA的性别差异及其与白天嗜睡和代谢脆弱性的关系 肥胖的男人和女人，没有和没有OSA。我们建议同时表征：1。睡觉觉醒 规定; 2。糖尿病风险的度量3。心血管风险的度量和4。性类固醇的特征， 皮质醇和脂肪因子没有OSA的肥胖男人，b。治疗前后的OSA肥胖男人 持续正气道压力（CPAP），c。肥胖的没有OSA的绝经前妇女和d。 CPAP治疗前后，肥胖的绝经前妇女患有OSA。这些完成 跨学科研究将提供一个独特的数据集，与肥胖女性与肥胖男性相比 睡眠与代谢综合征，OSA和代谢综合征与影响之间的关系 代谢综合征的CPAP治疗。拟议的工作将提供有关有关的重要见解 OSA的病理生理及其对肥胖男女的不利后果，也是 制定有效的性别预防和治疗策略。