VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Data and Biostatistics Core

VA-DoD 军事相关脑损伤联盟 (LIMBIC) 的长期影响：数据和生物统计学核心

• 批准号: 10534111
• 负责人: Mary Jo Pugh
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534111
• 关键词: Academia; Acute; Address; Area; Basic Science; Biological Markers; Biometry; Biostatistics Core; Brain; Brain Injuries; Caring; Characteristics; Chronic; Chronic Care; Clinical; Clinical Research; Collaborations; Core Facility; Data; Data Security; Dementia; Diagnostic; Elements; Enrollment; Epidemiology; Family member; Functional disorder; Funding; Funding Mechanisms; General Population; Guidelines; Head; Healthcare; Infrastructure; Knowledge; Late Effects; Leadership; Link; Long-Term Effects; Mental Health; Military Personnel; Mission; NIH Program Announcements; Nature; Nerve Degeneration; Nervous System Trauma; Neurocognitive Deficit; Neurodegenerative Disorders; Neurologic; Neurologic Signs; Neurosciences; Outcome; Pain; Phenotype; Population; Population Characteristics; Post-Traumatic Stress Disorders; Prevalence; Private Sector; Quality Control; Research; Research Personnel; Risk Factors; Sensory Disorders; Sleep; Support System; Symptoms; Therapeutic; Time; Veterans; Woman; Work; care systems; chronic pain; cohort; combat; comorbidity; data management; experience; follow-up; health economics; improved; knowledge translation; mild traumatic brain injury; neuroimaging; neurosensory; patient oriented; protective factors; research study; service member; tool

The Chronic Effects of Neurotrauma Consortium (CENC; W81XWH-13-2-0095) has been a highly productive, coordinated, multicenter, basic science-to-bedside, research collaboration led by VCU/VA researcher David Cifu, MD and jointly funded since 2013 by the DoD and VA. CENC linked basic, translational, epidemiologic, and clinical neuroscience researchers from the VA, military, academia, and private sector to effectively address the diagnostic challenges and therapeutic ramifications of mild traumatic brain injury (mTBI) and its potential long-term effects. Experienced and proven researchers from the CENC comprise the LIMBIC team at the level of Consortium Leadership, Core Facility, and Research Study Directors. This proven team of leaders, infrastructure supporters and researchers will initiate targeted, expanded research studies that extend CENC research findings, address all priorities (required and secondary research elements) detailed in the program announcement, and will produce deliverables for the clinicians in the field. The four infrastructure Cores (Biomarkers, Neuroimaging, Data and Biostatistics, Clinical Studies) will work in concert to accomplish three overarching, interrelated aims: Aim 1. Transition and expand CENC to LIMBIC -- Enroll and expand sizes of relevant cohorts of Veterans and Servicemembers; expand data points collected; collect data in accordance with established guidelines; and identify and describe key characteristics of populations to guide rigorous studies on the nature and degree of mTBI late effects in combat Vs/SMs over time. Aim 2. Comorbidities & Neurologic sequela -- Determine prevalence and associations of mTBI with important comorbidities and neurologic sequela, such as dementia and neurodegenerative disease, pain, psychological health including PTSD, and neurosensory deficits. Determine nature and degree of mTBI late effects over time. Aim 3. Phenotypes -- Identify characteristics (e.g., repetitive mTBI, deployment-only mTBI, frequent low level blast or other subconconcussive head/brain impact exposure, baseline neurocognitive deficits, presence of neurologic signs, presence of symptoms), pathophysiology, biomarkers, and subpopulations (e.g., women) that serve as risk or protective factors for long-term outcomes such as neurodegeneration, symptom burden and health economics. LIMBIC will continue the mission begun by CENC, which has the Veterans, Service Members, and their family members at the center of the work performed, to develop, deploy, and disseminate patient-centered health care tools and strategies. Work conducted to-date has expanded knowledge in the areas of chronic pain, sleep, sensory disorders, psychological health, and return to work. Knowledge translation underway includes improving both care and systems of care to the population, translatable to both military and the general public populations. We are poised to achieve LIMBIC’s intent to “improve acute TBI care and subsequent support systems for chronic care following mTBI”.

神经创伤联盟（CENC；W81XWH-13-2-0095）的慢性影响是一个高产、 由 VCU/VA 研究员 David 领导的协调、多中心、从基础科学到临床的研究合作 Cifu，医学博士，自 2013 年起由 DoD 和 VA 联合资助，将基础、转化、流行病学、 以及来自退伍军人管理局、军队、学术界和私营部门的临床神经科学研究人员，以有效解决 轻度创伤性脑损伤 (mTBI) 的诊断挑战和治疗后果及其潜力 LIMBIC 团队由 CENC 经验丰富且经过验证的研究人员组成。 由联盟领导层、核心设施和研究总监组成的这个久经考验的领导团队， 基础设施支持者和研究人员将启动有针对性的扩展研究，以扩展 CENC 研究结果，解决计划中详细说明的所有优先事项（必需的和次要的研究要素） 公告，并将为该领域的资深人士提供可交付成果。 四个基础设施核心（生物标记、神经影像、数据和生物统计学、临床研究）将在 音乐会以实现三个相互关联的总体目标： 目标 1. 将 CENC 过渡并扩展到 LIMBIC——注册并扩大相关退伍军人群体的规模 军人；扩大收集的数据点；按照既定准则收集数据； 识别和描述人口的关键特征，以指导对人口的性质和程度的严格研究 随着时间的推移，mTBI 对战斗 Vs/SM 的后期影响。 目标 2. 合并症和神经系统后遗症——确定 mTBI 的患病率以及与重要疾病的关联 合并症和神经系统后遗症，例如痴呆和神经退行性疾病、疼痛、心理 确定 mTBI 后期影响的性质和程度。 目标 3. 表型——识别特征（例如，重复性 mTBI、仅部署 mTBI、频繁低水平 爆炸或其他亚脑震荡性头部/大脑撞击暴露、基线神经认知缺陷、存在 神经体征、症状的存在）、病理生理学、生物标志物和亚群（例如女性） 作为长期结果的风险或保护因素，例如神经退行性变、症状负担和 卫生经济学。 LIMBIC 将继续执行由退伍军人、现役军人及其家人组成的 CENC 发起的使命 成员处于所执行工作的中心，开发、部署和传播以患者为中心的健康 迄今为止进行的工作扩大了慢性疼痛领域的知识， 正在进行的知识转化包括睡眠、感觉障碍、心理健康和重返工作岗位。 改善对民众的护理和护理系统，适用于军队和公众 我们准备实现 LIMBIC 的“改善急性 TBI 护理和后续支持”的意图。 mTBI 后的慢性护理系统。