Consequences of Maternal Vaping on Cerebrovascular Health in Offspring

母亲吸电子烟对后代脑血管健康的影响

• 批准号: 10537039
• 负责人: Amber Mills
• 金额: $ 4.68万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10537039
• 关键词: Adolescence; Adolescent; Adult; Adult Children; Aerosols; Alzheimer' s Disease; Arteries; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrovascular system; Chronic; Clinical; Data; Development; Electronic cigarette; Endothelium; Environment; Exposure to; Fetal Development; First Pregnancy Trimester; Functional disorder; Goals; Guidelines; Health; Health Personnel; Hypertension; Impairment; Individual; Inhalation Exposure; Knowledge; Life; Literature; Long-Term Effects; Maternal Exposure; Measurable; Neurocognitive Deficit; Nicotine; Outcome; Pattern; Pregnancy; Pregnant Women; Public Policy; Publishing; Recommendation; Recording of previous events; Regulation; Reporting; Resistance; Risk; Risk Factors; Rodent; Rodent Model; Second Pregnancy Trimester; Secondary to; Smoking; Structure; Testing; Third Pregnancy Trimester; Time; Toxic effect; Toxicology; Vascular Diseases; adolescent offspring; aged; base; cerebral microbleeds; cerebrovascular; cerebrovascular health; electronic cigarette use; expectation; in utero; maternal vaping; offspring; pre-clinical; preclinical study; prenatal exposure; response; smoking during pregnancy; stem; vaping; vascular abnormality; vascular risk factor

Project Summary/Abstract Electronic cigarettes (E-cigs) are promoted as an alternative to smoking during pregnancy, however the immediate and long-term effects are still unknown. Current estimates are that 5-16% of pregnant women will use e-cigs with the expectation that are either ‘reduced’ or ‘no’ risk to offspring health. Yet, inhalation exposures during pregnancy are of significant concern, because: 1) the developing fetus is at a vulnerable period, and 2) even ‘low-levels’ of smoking during pregnancy are known to have measurable vascular health risk to offspring. Thus, there is a critical need for preclinical studies to examine vascular related outcomes, particularly in the context of exposure during pregnancy. We have previously established the maternal vaping during pregnancy significantly impairs cerebral vascular function in offspring (even through adulthood). The goal of this proposal is to evaluate the direct effect of vape exposure on offspring born with prior history of in utero exposure due to maternal vaping, and secondly to determine whether full-term vs limited trimester exposure produces differences in cerebral vascular structure and function in offspring in adolescent and adult life. Based on our preliminary data, our overall hypothesis is that e- cig usage during pregnancy (irrespective of nicotine) creates a hostile gestational environment that leads to reduced cerebral vascularity and blunted vascular responses in offspring later in life. Aim 1 will combine direct e-cig exposure in adolescent- and adult-aged offspring that already have blunted cerebral vascular reactivity secondary to in utero exposure from maternal vaping. Aim 2 will use different exposure patterns of maternal vaping during pregnancy (full-term vs individual trimester exposures) to determine if there is critical exposure window that (more greatly) influences cerebral vascular structure and function in offspring. The proposed studies will identify consequences of maternal vaping combined with secondary direct exposure to offspring later in life; and identify what time frame during pregnancy that vaping might have the greatest influence on cerebral vascular health on offspring. We anticipate our data will provide toxicological and clinical evidence to inform clinicians and consumers on consequences of vaping during pregnancy, as well as information for regulatory agencies when establishing public policy, guidelines or regulations.

项目概要/摘要 电子烟（E-cigs）被宣传为怀孕期间吸烟的替代品， 然而，短期和长期影响仍未知，目前估计为 5-16%。 的孕妇会使用电子烟，期望“降低”或“无”风险 然而，怀孕期间的吸入暴露值得关注，因为：1) 发育中的胎儿正处于脆弱期，2）即使在怀孕期间也有“低水平”吸烟 众所周知，怀孕对后代有可测量的血管健康风险。 迫切需要临床前研究来检查血管相关结果，特别是在这种情况下 我们之前已经确定了母亲在怀孕期间吸电子烟的情况。 怀孕会显着损害后代（甚至成年后）的脑血管功能。 该提案的目标是评估电子烟暴露对出生时患有先天性电子烟的后代的直接影响 因母亲吸电子烟而在子宫内暴露的历史，其次是确定足月还是足月 有限的妊娠期暴露会导致脑血管结构和功能的差异 根据我们的初步数据，我们的总体假设是，e- 怀孕期间使用香烟（无论尼古丁如何）会造成恶劣的妊娠环境， 导致后代脑血管供应减少和血管反应减弱 目标 1 将把已经削弱的青少年和成年后代的直接电子烟暴露结合起来 目标 2 将使用因母亲电子烟在子宫内暴露而继发的脑血管反应。 母亲在怀孕期间接触电子烟的不同模式（足月与个别妊娠期） 曝光）以确定是否存在（更大）影响的关键曝光窗口 拟议的研究将确定后代的脑血管结构和功能。 母亲吸电子烟以及随后对后代的二次直接暴露的后果 生活；并确定电子烟对怀孕期间影响最大​​的时间段 我们预计我们的数据将提供毒理学和临床信息。 向消费者告知怀孕期间吸电子烟后果的证据，以及 作为监管机构制定公共政策、指南或法规时的信息。