ARIC

阿里克

• 批准号: 7648798
• 金额: $ 163.72万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7648798
• 关键词: ARIC

Over the past 20 years, the Atherosclerosis Risk In Communities (ARIC) Study has provided important new information on risk factors for atherosclerosis and its progression, on risk factors for coronary heart disease and stroke, and on trends in community rates of cardiovascular disease. We herein propose continuation of ARIC from 2005 to 2012. There are separate proposals for each ARIC Field Center, the Coordinating Center, and the Laboratories. Our aims for renewal in response to the ARIC RFPs are: 1. Completion of 23 years of coronary heart disease (CHD) surveillance in the four ARIC communities, permitting detection of trends in CHD Incidence, case fatality, and mortality in racesex-specific subgroups. For 2005-2009, CHD Surveillance will expand to 75-84 year olds, and inpatient heart failure (55 years and older) and outpatient heart failure surveillance (65 years and older) will be undertaken. 2. Follow-up of ARIC's previously examined cohort for cardiovascular disease (CVD) morbidity and mortality over 23 years, to identify factors related to Incident CHD, stroke, and for 2005-2009, heart failure. 3. Identification and characterization of novel genetic and biochemical risk factors for CVD using stored blood, urine, and DNA samples from available subclinical disease cases, available and newly-occurring CVD cases and control subjects, and subgroups with rapid progression of subclinical disease. The genes and analytes to be measured will be identified via a pathway approach to atherosclerosis and CVD. An extension will enable ARIC to continue to (1) address community trends in CVD and (2) make use of its valuable database and biosample resource to address new questions on the etiology of cardiovascular disease. The Collaborative Studies Coordinating Center has served as the ARIC coordinating center (CC) and will continue providing the overall operation and scientific coordination for the ARIC study with special emphasis on statistical methodology. CC staff will participate in all the ARIC committees and subcommittees, will coordinate conference calls and take minutes. The CC staff will actively participate in writing manuscripts as lead and co-authors and provide statistical advice, analyses and review when needed. The CC will maintain and participate in development of manuals, forms, and instructions. Training sessions will be coordinated by CC staff. Data management, including systems for data entry and systems to prepare data files for analyses, will be maintained and created for HF and mortality and morbidity classification (MMCC) for CHD and HF. All MMCC activities will be coordinated by CC. Quality control reports will be prepared and monitoring visits to field centers and central agencies will be on going. The CC will respond to needs of community surveillance (CHD and HF), AFU, and laboratory studies (including case-cohort studies) as issues arise. The CC will maintain and update two websites for ARIC. The CC will coordinate ARIC's efforts to disseminate data to investigators within and outside the ARIC scientists.

在过去的20年中，社区的动脉粥样硬化风险（ARIC）研究提供了有关动脉粥样硬化及其进展的危险因素的重要新信息，冠心病和中风的危险因素以及心血管疾病社区率的趋势。我们在这里提出了从2005年到2012年的ARIC的延续。每个ARIC野外中心，协调中心和实验室都有单独的建议。 我们对ARIC RFP的续订的目标是： 1。在四个ARIC群落中完成23年冠心病（CHD）监测，允许发现Racesex特异性亚组中CHD发病率，病例死亡和死亡率的趋势。在2005年至2009年，CHD监视将扩大到75-84岁，住院心力衰竭（55岁以上）和门诊心力衰竭监测（65岁及65岁以上）。 2。在23年内，ARIC先前检查的心血管疾病（CVD）发病率和死亡率的随访，以识别与事件冠心病，中风和2005年至2009年有关的因素。 3。使用可用的亚临床疾病病例的储存的血液，尿液和DNA样本，可用的和新的CVD病例和对照组对CVD的新遗传和生化危险因素的鉴定和表征，以及具有快速进展亚细胞学疾病的亚组。要测量的基因和分析物将通过动脉粥样硬化和CVD的途径方法来鉴定。 扩展将使ARIC能够继续（1）解决CVD中的社区趋势，（2）利用其宝贵的数据库和生物样品资源来解决有关心血管疾病病因的新问题。 协作协调中心的协作研究中心已担任ARIC协调中心（CC），并将继续为ARIC研究提供整体运营和科学协调，并特别强调统计方法。 CC工作人员将参加所有ARIC委员会和小组委员会，将协调电话会议并花费几分钟。 CC的工作人员将积极参与编写手稿作为主管和合着者，并在需要时提供统计建议，分析和审查。 CC将维护并参与手册，表格和说明的开发。培训课程将由CC工作人员协调。数据管理（包括用于数据输入的系统以及准备用于分析的数据文件的系统），将为HF，死亡率和发病率分类（MMCC）维护和创建。所有MMCC活动将由CC协调。将准备质量控制报告，并将监视野外中心和中央机构的访问。 CC将响应社区监视（CHD和HF），AFU和实验室研究（包括病例研究）的需求。 CC将维护和更新两个ARIC的网站。 CC将协调ARIC将数据传播给ARIC科学家内外的研究人员的努力。