Examining the Gut Microbiome in Haitians Post-Migration to the United States

检查海地人移居美国后的肠道微生物组

基本信息

批准号：
10523853
负责人：
Dany Fanfan
金额：
$ 13.62万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10523853
关键词：
Acculturation Achievement Address Adopted Anxiety Area Asian population Behavior Behavior Therapy Bioinformatics Biological Process Characteristics Cohort Studies Country Cultural Characteristics Development Diet Habits Dietary Practices Economic Burden Education Employment Exposure to Fatigue Foundations Future Genomics Goals Haitian Health Health Promotion Healthy Eating Home Household Immigrant Immigration Income Intervention Knowledge Latino Population Length Life Style Link Mental Depression Mentors Nursing Research Outcome Pain Personal Satisfaction Persons Phylogenetic Analysis Physical activity Play Policies Population Psyche structure Quality of life Reduce health disparities Reporting Research Research Personnel Ribosomal RNA Risk Role Science Senior Scientist Services Social Environment Social Identification Stress Subgroup Symptoms Time Training Translating Underserved Population United States Work base biobehavior disability ethnic minority experience functional disability gut microbiome gut-brain axis health disparity health equity holistic approach improved microbial microbial genome microbiome composition microbiota migration perceived stress personalized intervention psychological distress psychosocial residence social culture social health determinants sociodemographic factors sociodemographics stool sample stressor symptom science tool translational research program

项目摘要

ABSTRACT. Haitians comprise one of the fastest growing subgroups of immigrants in the US. These immigrants experience high levels of psychological distress (i.e., depression, anxiety, fatigue, and pain), contributing to progressive functional impairment, disability, economic burden, and poor long-term health outcomes. Knowledge of factors contributing to psychological distress early in the post-migration period and longitudinally will help inform type and timing of interventions to reduce the disabling effects of psychological distress and improve quality of life for this underserved population. Yet no studies have examined psychological distress and its underlying biobehavioral, psychosocial, and cultural characteristics in Haitian immigrants within the first few months of residence in the US or over time. While multiple biological processes may be associated with psychological distress, rising evidence suggests that gut microbiome (GM) diversity and composition play an important role via the bidirectional microbiome-gut-brain axis. After migration, changes in GM composition and diversity embody changes in the social determinants of health ([SDoH]; e.g., stress, sociodemographic factors, lifestyle behaviors, dietary patterns, acculturation, environmental and sociocultural conditions) that also contribute to risk for psychological distress. With more time in the US, the GM of recent immigrants becomes more Westernized, with reductions of microbial phylogenetic diversity and native GM species as well as genera-level shifts in microbiota abundance. The SDoH that drive these GM changes are modifiable through culturally responsive interventions. The GM thus has the potential to serve as both an early indicator of risk for psychological distress and a tool to mitigate its effects. The overall goal for this longitudinal pilot cohort study is to investigate associations between psychological distress, GM composition/diversity, and post-migration SDoH in recent Haitian immigrants to the US. Specific aims are to 1) Characterize the GM in 60 recent Haitian immigrants by analyzing self-collected stool samples at T1 (< 6 months in the US) and T2 (6 months after T1) and describe changes in composition/diversity over time and 2) Examine longitudinal associations between post-migration SDoH, GM composition/diversity, and psychological distress among recent Haitian immigrants. I hypothesize that, in recent Haitian immigrants, a) migration to the US is associated with changes in GM composition and diversity over time, and b) changes in GM composition and diversity are associated with changes in post-migration SDoH and psychological distress. The PI has assembled an interdisciplinary mentoring team of senior scientists with expertise in symptom science, GM, biocultural approaches, immigrant health disparities, genomics, and bioinformatics. This project will provide the foundation for the PI to build an independent translational research program focused on developing culturally responsive targeted interventions that mitigate psychological distress, improve long-term health outcomes, reduce health disparities, and increase health equity in ethnic-minority immigrant populations.

抽象的。海地人是美国增长最快的移民群体之一。这些移民经历高度的心理困扰（即抑郁、焦虑、疲劳和疼痛），导致进行性功能障碍、残疾、经济负担和长期健康状况不佳结果。了解移民后早期造成心理困扰的因素，以及纵向将有助于了解干预措施的类型和时机，以减少心理障碍的致残影响为这些服务不足的人群减轻痛苦并提高他们的生活质量。但还没有研究检验过海地人的心理困扰及其潜在的生物行为、心理社会和文化特征移民在美国居住的头几个月内或随着时间的推移。虽然多种生物过程可能与心理困扰有关，越来越多的证据表明肠道微生物组 (GM) 多样性和组成通过双向微生物组-肠-脑轴发挥重要作用。迁移后，转基因成分和多样性的变化体现了健康社会决定因素的变化（[SDoH]；例如，压力、社会人口因素、生活方式、饮食模式、文化适应、环境和社会文化条件）也会导致心理困扰的风险。随着在美国的时间越来越长，新移民的转基因变得更加西化，微生物系统发育多样性减少，本土转基因物种以及微生物群丰度的属水平变化。推动这些 GM 的 SDoH 可以通过文化响应干预措施来改变变化。因此，总经理有潜力担任既是心理困扰风险的早期指标，也是减轻其影响的工具。总体目标为这项纵向试点队列研究旨在调查心理困扰、GM 之间的关联近期海地移民到美国的构成/多样性和移民后 SDoH。具体目标是 1) 通过分析 T1 时自行收集的粪便样本（< 6 在美国的几个月）和 T2（T1 后 6 个月）并描述成分/多样性随时间的变化以及 2) 检查迁移后 SDoH、GM 组成/多样性和心理之间的纵向关联新近海地移民的困境。我假设，在最近的海地移民中，a) 迁移到 US 与 GM 组成和多样性随时间的变化有关，b) GM 组成的变化多样性与移民后 SDoH 的变化和心理困扰有关。该PI有组建了一支由资深科学家组成的跨学科指导团队，他们在症状科学、转基因、生物文化方法、移民健康差异、基因组学和生物信息学。该项目将提供为 PI 建立一个专注于文化发展的独立转化研究项目奠定了基础响应性有针对性的干预措施，可减轻心理困扰，改善长期健康结果，缩小少数民族移民人口的健康差距，提高健康公平性。