Diverse drug lead compounds from bacterial symbionts in tropical marine mollusks

来自热带海洋软体动物细菌共生体的多种药物先导化合物

• 批准号: 7536918
• 负责人: Margo Genevieve Haygood
• 金额: $ 65.7万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7536918
• 关键词: Academy; Address; Adult; Anatomy; Animals; Archives; Area; Arts; Bacteria; Beds; Biodiversity; Bioinformatics; Biological Factors; Biology; Biomass; Biotechnology; Bivalvia; Cellulases; Chemicals; Chemistry; Collection; Communities; Conus genus; Data; Databases; Development; Diet; Distel; Eating; Ecology; Education; Ensure; Environment; Enzymes; Equipment and supply inventories; Eukaryota; Eukaryotic Cell; Exhibits; Family; Figs - dietary; Foundations; Future; Gap Junctions; Genome; Goals; Government; Habitats; Human; Individual; Lead; Link; Malignant Neoplasms; Malignant neoplasm of central nervous system; Maps; Marines; Metabolism; Methodology; Microbe; Microbiology; Natural Resources; Natural Sciences; Neuraxis; Nexus (resin cement); Numbers; Oceans; Oregon; Organ; Pathway interactions; Pattern; Pharmaceutical Preparations; Pharmacologic Substance; Philadelphia; Philippines; Plant Roots; Plants; Poaceae; Policies; Population; Predatory Behavior; Private Sector; Production; Research; Resources; Retinal Cone; Role; Sampling; Science; Scientist; Screening procedure; Sea; Site; Snail Venoms; Snails; Specimen; Standards of Weights and Measures; Structure; Students; Surveys; Symbiosis; Taxonomy; Technology; Technology Transfer; Testing; Time; Training; Transfer Agreement; Universities; Utah; Wood material; antimicrobial; cellulase; comparative; coral; drug discovery; interest; marine natural product; microbial; microbial community; microorganism; migration; outreach; programs; tool

DESCRIPTION (provided by applicant): The Philippine Mollusk Symbiont ICBG (PMS ICBG) project links a biodiversity survey of marine mollusks in one of the world's hotspots of diversity, with drug discovery and enzyme bioprospecting aimed at bacterial symbionts of mollusks. Mollusks constitute the most diverse marine eukaryotic group, occupying virtually every possible ecological niche. The diversity of microbes associated with mollusks is equally vast. Within the mollusks, three particular groups exhibit what we believe to be the highest biotechnological and scientific potential: the bivalve family Teredinidae (genus Teredo) and the gastropod superfamilies Conoidea (genus Conus) and Muricoidea (genus Murex). The project directly addresses the goals of the ICBG program and will yield drug leads in central nervous system, cancer and antimicrobial areas, as well as strains and enzymes for cellulosic biofuels production. The project will characterize symbiotic diversity and pharmaceutical and biofuels potential of mollusk-associated bacteria in a comparative framework for the first time. The plan focuses on training, conservation, and the development of drug discovery and biofuels programs within the Philippines. The Republic of the Philippines represents a unique nexus of exceptional biodiversity, dense human population with pressing societal and energy needs, consequent urgent conservation goals, and government and private sector commitment to education and technology to harness national human and natural resources for a sustainable future The project is led by Margo Haygood, marine microbiologist, Oregon Heath & Science University, in association with Gisela Concepcion, marine natural products chemist, University of the Philippines, Baldomero Olivera, biochemist, and Eric Schmidt, natural products chemist and biochemist, both of University of Utah, Gary Rosenberg, evolutionary biologist, Academy of Natural Sciences, Philadelphia, and Daniel Distel, marine microbiologist, Ocean Genome Legacy.

描述（由申请人提供）：菲律宾软体动物共生体 ICBG (PMS ICBG) 项目将世界多样性热点之一的海洋软体动物生物多样性调查与针对软体动物细菌共生体的药物发现和酶生物勘探联系起来。软体动物是最多样化的海洋真核生物群体，几乎占据了所有可能的生态位。与软体动物相关的微生物的多样性同样巨大。在软体动物中，我们认为三个特定类群表现出最高的生物技术和科学潜力：双壳类 Teredinidae（Teredo 属）和腹足动物总科 Conoidea（Conus 属）和 Muricoidea（Murex 属）。该项目直接实现了 ICBG 计划的目标，并将产生中枢神经系统、癌症和抗菌领域的先导药物，以及用于生产纤维素生物燃料的菌株和酶。该项目将首次在比较框架中描述软体动物相关细菌的共生多样性以及制药和生物燃料潜力。该计划的重点是菲律宾境内药物发现和生物燃料项目的培训、保护和开发。菲律宾共和国代表了一种独特的联系：卓越的生物多样性、人口稠密、紧迫的社会和能源需求、随之而来的紧迫的保护目标，以及政府和私营部门对教育和技术的承诺，以利用国家人力和自然资源实现可持续的未来。该项目由俄勒冈健康与科学大学海洋微生物学家 Margo Haygood 领导，与菲律宾大学海洋天然产物化学家 Gisela Concepcion、生物化学家 Baldomero Olivera 和 Eric 合作施密特（Schmidt）是犹他大学的天然产物化学家和生物化学家，加里·罗森伯格（Gary Rosenberg）是费城自然科学院的进化生物学家，丹尼尔·迪斯特（Daniel Distel）是海洋基因组遗产公司的海洋微生物学家。