Advanced acoustic field measurements of shock wave lithotripters

冲击波碎石机的先进声场测量

• 批准号: 7588478
• 负责人: Jeffrey Ketterling
• 金额: $ 19.08万
• 依托单位: RIVERSIDE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7588478
• 关键词: Acoustics; Address; Adult; Boston; CHRM3 gene; Calculi; Calibration; Classification; Clinical; Complex; Device Designs; Device or Instrument Development; Devices; Dimensions; Electrodes; Electromagnetics; Elements; Ensure; FDA approved; Failure; Frequencies; Future; Goals; Gold; Image; Incidence; Indium; Injury; Intervention; Kidney; Kidney Calculi; Laboratories; Length of Stay; Lithotripsy; Location; Marketing; Measurement; Measures; Medical; Membrane; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Operative Surgical Procedures; Outcome; Patients; Pattern; Performance; Process; Property; Safety; Shock; System; Techniques; Testing; Theoretical model; Tissues; Transducers; Translating; Trauma; Ultrasonography; Universities; Ureter; Variant; Washington; Work; aged; base; clinical efficacy; design; improved; in vivo; novel; physical process; pressure; public health relevance; research study; simulation; sound; standard care

DESCRIPTION (provided by applicant): The goal of this project is to measure the instantaneous acoustic field of shock wave lithotripters (SWL) using a linear hydrophone array. All previous measurements of SWL acoustic fields have been performed with single-element hydrophones which are only effective if the sound field does not vary from shock to shock. Specifically, we propose to 1) fabricate linear hydrophone arrays based on techniques developed for high-frequency imaging arrays, 2) characterize the arrays electrically and acoustically, 3) drive the arrays to failure to determine durability, and 4) test the arrays in SWL devices to improve the understanding of the instantaneous acoustic field. The proposed measurements would represent the first instantaneous "snapshot" of an SWL acoustic field and would have broad implications for lithotripter device design, theoretical models of stone fragmentation, device calibration, and patient management. SWL has been employed for nearly 25 years to non-invasively treat kidney stones and is utilized in H 50% of the treatments when medical intervention is required. According to the National Institute of Diabetes and Digestive and Kidney Diseases, 5.2% of adults aged 20 to 74 have had kidney stones and H 171,000 adults require a hospital stay each year to undergo treatment of "calculus of kidney and ureters." Even though "improved" SWL systems have come to market, the original Dornier HM3 is still considered the gold standard in treatment. However, the acoustic field of the HM3, when measured at a single point, varies by as much as 50%. This variation is thought to improve stone fragmentation but it also increases the likelihood of trauma to the surrounding kidney tissue. The proposed linear hydrophone array will be fabricated at RRI by Dr. Ketterling. The initial array design will have 20 elements and span 18 mm. After validating the basic operation of the array at RRI, additional arrays will be fabricated and sent to Dr. Cleveland at Boston University and Dr. Bailey at the University of Washington. The arrays will then be employed to make the first instantaneous acoustic field measurements of the three major classes of SWL systems: electrohydraulic, electromagnetic, and piezoelectric lithotripters. The measurements will yield important information about the dimensions and peak pressure location of the instantaneous acoustic field, the effect on the acoustic field of different reflectors, and the performance of new versus old electrodes. A successful outcome of this project will, ultimately, help improve clinical efficacy through more efficient stone fragmentation and improve clinical safety by reducing tissue damage. PUBLIC HEALTH RELEVANCE: The ultimate goal of this work is to improve the efficacy of shock wave lithotripsy (SWL) treatment of kidney stones by more efficiently fragmenting the stones while exposing the surrounding kidney tissue to minimal trauma. The proposed measurements would represent the first instantaneous acoustic field measurements of SWL systems and would provide valuable information that could be used to improve lithotripter devices, theoretical models of stone fragmentation, device calibration, and patient management.

描述（由申请人提供）：该项目的目的是使用线性水文阵列测量冲击波岩石纤维（SWL）的瞬时声场。 SWL声场的所有先前测量都已使用单元素言进行，只有在声场不随冲击和冲击而变化时，这些水音器才有效。具体而言，我们建议1）基于为高频成像阵列开发的技术制造线性水文阵列，2）2）用电气和声学表征阵列，3）3）使阵列无法确定耐用性，4）4）测试SWL设备中的阵列以提高对即时声学场的理解。所提出的测量值将代表SWL声场的第一个瞬时“快照”，并将对岩石夹器设备设计，石材碎片，设备校准和患者管理的理论模型具有广泛的影响。 SWL已雇用了将近25年的非侵入性治疗肾结石，并在需要医疗干预时在H 50％的治疗方法中使用。根据国家糖尿病和消化研究所和肾脏疾病的研究，20至74岁的成年人中有5.2％患有肾结石，H 171,000名成年人每年需要住院，以接受“肾脏和输尿管的计算”。即使“改进”的SWL系统已上市，但原始的Dornier HM3仍被认为是治疗的黄金标准。但是，当单点测量时，HM3的声场变化多达50％。人们认为这种变化可以改善石材碎片化，但也增加了周围肾脏组织创伤的可能性。提出的线性水文阵列将由Ketterling博士在RRI上制造。初始阵列设计将具有20个元素，并跨度18毫米。在验证了RRI阵列的基本操作之后，将制造其他阵列并将其发送给波士顿大学的克利夫兰博士和华盛顿大学的贝利博士。然后，将使用阵列进行三个主要类别SWL系统的首个瞬时声场测量值：电氢气，电磁和压电岩石纤维。测量结果将产生有关瞬时声场的尺寸和峰值压力位置的重要信息，对不同反射器的声场的影响以及新电极与旧电极的性能。最终，该项目的成功结果将有助于通过更有效的石材碎片化来提高临床功效，并通过减少组织损伤来改善临床安全性。公共卫生相关性：这项工作的最终目的是通过更有效地碎裂石头，同时将周围的肾脏组织暴露于最小的创伤，从而提高肾结石的冲击波碎石（SWL）处理的功效。所提出的测量值将代表SWL系统的第一个瞬时声场测量值，并将提供可用于改善岩石夹设备，石材碎片化的理论模型，设备校准和患者管理的有价值的信息。