Women's Health Initiative Field Center

妇女健康倡议现场中心

• 批准号: 7648750
• 金额: $ 26.52万
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7648750
• 关键词: Women; Health; Initiative; Field; Center

The purpose of the Women's Health Initiative (WHI) is to address cardiovascular disease, cancers of the breast and colon/rectum, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women. The major components of the WHI are: a randomized controlled clinical trial of postmenopausal Hormone Therapy (HT), Dietary Modification (DM), and Calcium/Vitamin D supplementation (CaD); and a companion observational study (OS). The Clinical Trials and Observational Study components were completed in 2005; the WHI Extension Study continues to follow all consenting participants for health outcomes and selected exposures. The purpose of this additional follow-up is to describe the longer term effects of the original interventions, to document change in hormone use in participants from the HT trials, to expand the range of scientific questions that can be reliably addressed in the WHI, and to provide an infrastructure able to support additional investigations requiring some of the unique resources of a very large longitudinal study of postmenopausal women.

妇女健康倡议 (WHI) 的目的是解决心血管疾病、乳腺癌和结肠/直肠癌以及骨质疏松症等绝经后妇女死亡、残疾和生活质量受损的最常见原因。 WHI 的主要组成部分是：绝经后激素治疗 (HT)、饮食调整 (DM) 和钙/维生素 D 补充剂 (CaD) 的随机对照临床试验；和一项伴随观察研究（OS）。临床试验和观察研究部分于 2005 年完成； WHI 扩展研究继续跟踪所有同意的参与者的健康结果和选定的暴露情况。这一额外后续行动的目的是描述原始干预措施的长期影响，记录 HT 试验参与者激素使用的变化，扩大 WHI 中可以可靠解决的科学问题的范围，以及提供能够支持额外调查的基础设施，这些调查需要对绝经后妇女进行大规模纵向研究的一些独特资源。