Continuation of Follow-up of DES-exposed Cohorts

继续对 DES 暴露组进行随访

• 批准号: 7693568
• 金额: $ 19.56万
• 依托单位: METHODIST HOSPITAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7693568
• 关键词: Continuation; Follow; up; DES; exposed

1. Maintain contact with the DES-exposed individuals and unexposed controls already being followed in our follow-up program. This will be accomplished through two questionnaires sent to the participants during the period of the contract. 2. Continue to identify new third generation female offspring whose mothers were exposed in utero to DES and to examine these young women in a manner similar to the examination performed on their mothers in enrollment in the DESAD project. 3. Continue to evaluate the incidence of genital tract neoplasia in the exposed and unexposed cohorts as well as the mothers who took DES during their pregnancies. 4. Continue to estimate the incidence of intra epithelial neoplasia of the cervix and vagina. 5. Continue to evaluate the incidence of other benign and malignant neoplasms found in the DES-exposed cohorts. 6. Continue to assess the immunologic status of the subjects by determining the life-time occurrence of autoimmune diseases of exposed individuals as compared to the unexposed. 7. Continue to monitor the occurrence of medical disease in the exposed and unexposed cohorts and to make comparisons among them with published disease rates. 8. Obtain and confirm information of the diagnosis of all reported neoplasms in the DES and control cohorts.

1。在我们的后续计划中保持与暴露的个体和未暴露的对照的联系。这将通过合同期间发送给参与者的两份问卷来完成。 2。继续确定新的第三代女性后代，其母亲在子宫内暴露于DES，并以类似于对母亲在DESAD项目入学的考试的方式检查这些年轻女性。 3。继续评估生殖道肿瘤在暴露和未暴露的队列中以及在怀孕期间接受DES的母亲的发生率。 4。继续估计子宫颈和阴道上皮内肿瘤的发生率。 5。继续评估暴露于DES的队列中其他良性和恶性肿瘤的发生率。 6。继续通过确定暴露个体的自身免疫性疾病的生命时间来评估受试者的免疫状态。 7。继续监测暴露和未暴露的队列中医学疾病的发生，并与已发表的疾病率进行比较。 8。获取并确认DES和对照组中所有报告的肿瘤诊断的信息。