Infrastructure Improvements for the Sabana Seca Field Station of the Caribbean Pr

加勒比项目 Sabana Seca 现场站的基础设施改善

• 批准号: 7630746
• 负责人: Janis A. Gonzalez-Martinez
• 金额: $ 50万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-04 至 2013-03-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7630746
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Biomedical Research; Breeding; Caribbean region; Development; Elements; Funding; Genetic Status; Grant; Institution; Macaca mulatta; Monkeys; Operative Surgical Procedures; Output; Primates; Provider; Research; Research Infrastructure; Research Personnel; Research Project Grants; Testing; Vaccine Research; Water; animal care; nonhuman primate; prevent; programs; reproductive; therapeutic vaccine

DESCRIPTION (provided by applicant): For 38 years the Caribbean Primate Research Center (CPRC) has been supporting high-quality, productive research by providing high-quality rhesus macaques for research initiatives of National importance. During the past 8 years, the CPRC provided over 1,300 monkeys to PHS and NIH-sponsored biomedical research programs supporting over $142 million in federal grants. Over $76 million of this amount was for AIDS-related and vaccine research initiatives. The CPRC is the second largest SPF colony in the Nation, and one of the largest SPF rhesus macaque providers for AIDS related research projects. In order to maintain quality animal care standards and comply with regulatory agencies, the CPRC needs to renovate critical elements of the infrastructure support facilities at the Sabana Seca Field Station. Funds from this application will be used for the following: 1) upgrade of the electrical infrastructure, 2) renovation of the primary deep-water well and 3) renovation of animal enclosures. We foresee the increased need for non-human primates for testing newly developed therapeutics and vaccines, and our concern is that the lack of an adequate infrastructure could prevent the development of the animal care program and research initiatives at the CPRC. The proposed improvements will enhance the rhesus monkey breeding operation and this will result in an increase of the reproductive output of the colony. This will in turn assure that more Indian-origin rhesus macaques of defined virological and genetic status are made available to NIH-funded researchers and institutions.

描述（由申请人提供）：38年来，加勒比灵长类动物研究中心（CPRC）一直通过为国家重要性的研究计划提供高质量的恒河猕猴来支持高质量的生产研究。在过去的8年中，CPRC为PHS和NIH赞助的生物医学研究计划提供了1300多只猴子，为联邦赠款提供了超过1.42亿美元的支持。这笔款项的7600万美元用于与艾滋病有关的疫苗研究计划。 CPRC是美国第二大SPF殖民地，也是SPF恒河猴相​​关研究项目的最大的SPF Rhesus猕猴提供商之一。为了维持优质的动物护理标准并遵守监管​​机构，CPRC需要翻新Sabana Seca Field Station基础设施支持设施的关键要素。该应用程序的资金将用于以下：1）电气基础设施的升级，2）对主要深水井的翻新和3）动物外壳的翻新。我们预见到非人类灵长类动物对测试新开发的治疗剂和疫苗的需求增加，我们担心的是，缺乏适当的基础设施可以阻止CPRC的动物护理计划和研究计划的发展。拟议的改进将增强恒河猴的繁殖操作，这将导致菌落的生殖产量增加。反过来，这将确保更多的印度 - 原始恒河猕猴可供NIH资助的研究人员和机构提供。