Prevention Epicenters Program: Protecting Patients from Infections, Antibiotic Resistance andOther Adverse Events

预防中心计划：保护患者免受感染、抗生素耐药性和其他不良事件的影响

• 批准号: 10650204
• 负责人: ANTHONY D HARRIS
• 金额: $ 142.4万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650204
• 关键词: Prevention; Epicenters; Program; Protecting; Patients

We have been a member of the Prevention Epicenters (Cycle II, RFA-CK-18-001) since 2015. Our core investigative group has over 430 publications in the area of healthcare-associated infections and antibiotic resistance which have been cited over 12,000 times. The leaders of our core projects have had more than 27 grants and contracts as principal investigators and have over 350 publications in the scientific expertise areas in the RFA. We have collaborated with the current Epicenter II sites on 53 publications since 2015 and have collaborated with current Epicenter I sites on 35 publications. One of our group’s greatest strengths is our ability to leverage our experience and expertise to complete collaborative projects among the existing Epicenters and other healthcare institutions. We propose core and collaborative projects that are innovative, feasible and responsive to CDC priority areas. Our core proposals are: 1. State-wide prevalence of multi-drug resistant Acinetobacter baumannii in ventilated patients in acute and long-term facilities. 2. Evaluation of use and usability of surveillance for hospital-onset bacteremia and fungemia in acute care facilities 3. Decreasing Transmission of Multi-drug Resistant Organisms in Chronic Ventilator Units in Nursing Homes 4. Assessing feasibility of a targeted approach to contact precautions for MRSA in the acute care setting 5. Improving clinician microbiology test interpretation and use in all healthcare settings Our collaborative project proposals are: 1. Risk factors associated with transmission of Candida auris in the acute care setting (Large Project) 2. Diagnostic Stewardship for Ventilator Associated Pneumonia: A cluster-randomized crossover trial of a hybrid order-review and laboratory reporting intervention in acute care facilities (Medium project) Through these projects and the development of other collaborative projects, we look forward to contributing to the Prevention Epicenters Program: Protecting Patients from Infections, Antibiotic Resistance and Other Adverse Events.

自 2015 年以来，我们一直是预防中心 (Cycle II, RFA-CK-18-001) 的成员。我们的核心 调查小组在医疗保健相关感染和抗生素领域发表了 430 多篇出版物 我们核心项目的领导者已被引用超过 27 次。 作为主要研究人员获得资助和合同，并在科学专业领域发表 350 多篇出版物 自 2015 年以来，我们已与当前的 Epicenter II 站点合作发表了 53 份出版物。 与当前的 Epicenter I 站点合作出版了 35 份出版物。 能够利用我们的经验和专业知识来完成现有合作项目 我们提出创新的核心和合作项目。 可行并响应 CDC 优先领域。 我们的核心建议是： 1.全州范围内急症和重症通气患者中多重耐药鲍曼不动杆菌的患病率 长期设施。 2. 急性护理中院内菌血症和真菌血症监测的使用和可用性评估 设施 3. 减少疗养院慢性呼吸机中多重耐药菌的传播 4. 评估在急症护理环境中针对 MRSA 采取有针对性的接触预防措施的可行性 5. 改善临床医生微生物学测试的解释和在所有医疗保健环境中的使用 我们的合作项目建议是： 1. 与急性护理环境中耳念珠菌传播相关的危险因素（大型项目） 2. 呼吸机相关肺炎的诊断管理：一项整群随机交叉试验 急症护理机构中的混合医嘱审查和实验室报告干预（中型项目） 通过这些项目和其他合作项目的开发，我们期待为 预防中心计划：保护患者免受感染、抗生素耐药性等 不良事件。