EVAL OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ADRENOMEDULLARY FUNCTION

下丘脑-垂体-肾上腺轴和肾上腺髓质功能的评估

• 批准号: 7982157
• 负责人: MITCHELL GEFFNER
• 金额: $ 2.2万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982157
• 关键词: Adrenal Glands; Affect; CRH gene; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Corticotropin; Disease; Epinephrine; Funding; Glucocorticoids; Grant; Hydrocortisone; Institution; Measures; Metanephrine; Patients; Pharmaceutical Preparations; Plasma; Research; Research Personnel; Resources; Simulate; Source; Stress; United States National Institutes of Health; hypothalamic-pituitary-adrenal axis; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In patients with non classical adrenal hyperlasia, the hypothalamic-pituitary-adrenal axis is midly affected by the disease and only minimally further suppressed by the administration of glucocorticoid medication. It is unknown whether adrenomedullary function is also compromised in these patients. We hypothesize that these patients can mount an appropriate endogenous cortisol response to stress and that their adrenomedullary function is intact. The study purpose is: 1; To examine ACTH and cortisol responses under stress ;simulated by CRH administration& in patients with NCAH, 2; To measure plasma total metanephrine, free metanephrine, and epinephrine under similar stress conditions, 3; To extrapolate from thse findings as to whether glucocorticoid coverage during periods of stress is necessary for patients with NCAH.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在非经典性肾上腺高质症的患者中，下丘脑 - 垂体 - 肾上腺轴中间受该疾病的影响，只有受到糖皮质激素药物的给药而进一步抑制。 在这些患者中，肾上腺替代功能是否也受到损害，尚不清楚。 我们假设这些患者可以对应激的适当内源性皮质醇反应施加适当的内源性皮质醇反应，并且他们的肾上腺肾上腺肾上腺素功能完好无损。 研究目的是：1;在压力下检查ACTH和皮质醇反应；由CRH给药和NCAH患者模拟2；在类似的应力条件下，测量血浆总倍肽，游离属肾上腺素和肾上腺素，3；为了推断出关于NCAH患者在压力期间是否需要糖皮质激素覆盖范围的发现。