Molecular, Cellular, and Developmental Mechanisms

分子、细胞和发育机制

• 批准号: 10650331
• 负责人: David L. Van Vactor
• 金额: $ 106.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650331
• 关键词: Development; Molecular

Project Summary/Abstract In the 21st century, advances in knowledge, research technologies, and analytical tools have created unprecedented opportunities for major breakthroughs in our understanding of fundamental biological principles and their underlying mechanisms. We propose here a new interdisciplinary program in Molecular, Cellular, and Developmental Mechanisms (MCDM) at Harvard Medical School (HMS) that will build on our recent investments in science infrastructure, education, and training. Our goal is to educate a diverse, rigorous, and independent group of scientists who will identify novel essential questions in mechanistic biology and develop incisive tools for addressing them. Based on our successful predecessor T32 program, we plan to recruit a group of 20 trainees per year beginning in their second year of graduate study from the Biological and Biomedical Sciences umbrella program. These 20 trainees will distribute across a group of 80 MCDM preceptor laboratories. Our approach to cultivating a resilient and creative group of scholars will be both evidence-based and student-centered. We will bring innovative programming to an exceptionally talented pool of trainees. Through continuous improvements in mentorship practice, community engagement and inclusion, we will foster a collaborative community of scholars who are well-prepared to make confident and transformative contributions to life science research and the many research-related careers needed to convert new discoveries about fundamental biological mechanisms into biomedical and life-sciences applications.

项目概要/摘要 21世纪，知识、研究技术和分析工具的进步创造了 我们对基本生物学原理的理解有前所未有的重大突破机会 及其基本机制。我们在此提出一个新的分子、细胞和分子跨学科项目 哈佛医学院 (HMS) 的发育机制 (MCDM) 将建立在我们最近投资的基础上 科学基础设施、教育和培训。我们的目标是培养多元化、严谨、独立的人才 一群科学家将确定机械生物学中新颖的基本问题并开发精辟的工具 来解决他们的问题。基于我们之前成功的T32项目，我们计划招募一批20名学员 从生物和生物医学科学研究生第二年开始每年 程序。这 20 名学员将分布在 80 个 MCDM 导师实验室中。我们的方法 培养一支有韧性和创造力的学者群体将既以证据为基础，又以学生为中心。我们将 为才华横溢的学员带来创新的编程。通过持续改进 在指导实践、社区参与和包容方面，我们将培养一个协作社区 做好充分准备为生命科学研究做出自信和变革性贡献的学者 将基本生物机制的新发现转化为所需的许多与研究相关的职业 进入生物医学和生命科学应用。