ALPHA-HERPESVIRUS TRANSPORT IN AXONS

轴突中的α-疱疹病毒运输

基本信息

批准号：
10649492
负责人：
Gregory Allan Smith
金额：
$ 39.68万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-02-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10649492
关键词：
Afferent Neurons Alphaherpesvirinae Antiviral Agents Axon Axonal Transport Binding Binding Sites Brain Capsid Cell Nucleus Cells Centrosome Complex DNA Viruses Disease Dynein ATPase Encephalitis Experimental Designs Eye Family Family member Gene Delivery Genetic Genome Goals Herpes zoster disease Herpesviridae Herpesvirus 1 Herpesvirus Type 3 Human Herpesvirus 2 Immunocompetent Infection Injections Invaded Keratitis Kinesin Malignant Neoplasms Maps Microtubules Modeling Morbidity - disease rate Mothers Motion Motor Mutation Nervous System Neuroglia Neurons Newborn Infant Nuclear Pore Oncolytic Pattern Peripheral Production Property Proteins Research Resources Role Simplexvirus Site Structure Synapses Technology Tracer Trauma Ubiquitination Vaccines Varicellovirus Viral Viral Genome Viral Vector Virion Virus Virus Diseases design expectation human pathogen latent infection mad itch virus member mortality neonatal infection neural pathogen programs recruit repaired tissue tropism trafficking trait ubiquitin-protein ligase vector

项目摘要

Spread of neuroinvasive herpesviruses from sensory neurons to the eye, brain or from mother to newborn, are significant causes of morbidity and mortality. Herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PRV) are representative members of the two genuses of mammalian neuroinvasive herpesviruses (Simplexviruses & Varicelloviruses). These viruses are dependent upon spread to the nervous system to establish life-long latent infections, yet very little is known regarding the neuroinvasive mechanism that underlies this remarkable trait. We propose to study the virus neuroinvasive machinery with the intent to: (i) decipher how these viruses invade the nervous system, (ii) understand the intrinsic barriers to neural infection that these viruses evade, and (iii) produce and characterize viruses lacking the neuroinvasive property as potential vaccines. These studies are designed to decode the virus tactics used to establish neural infections and our corresponding nervous system’s defenses that keep most pathogens at bay.

神经侵袭性疱疹病毒从感觉神经元传播到眼睛、大脑或从母亲传播到新生儿，是发病和死亡的重要原因。1 型单纯疱疹病毒 (HSV-1) 和伪狂犬病病毒 (PRV) 是这两个属的代表性成员。哺乳动物神经侵袭性疱疹病毒（单纯病毒和水痘病毒）这些病毒依赖于传播到神经系统来建立终生潜伏感染，但人们对神经侵袭性知之甚少。我们建议研究病毒神经侵袭机制，目的是：（i）破译这些病毒如何侵入神经系统，（ii）了解这些病毒逃避的神经感染的内在障碍，以及（iii））生产和表征缺乏神经侵袭特性的病毒作为潜在的疫苗。这些研究旨在解码用于建立神经感染的病毒策略以及我们相应的神经系统的防御机制，以阻止大多数病原体。

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Crystal structure of the herpesvirus inner tegument protein UL37 supports its essential role in control of viral trafficking.

疱疹病毒内皮蛋白 UL37 的晶体结构支持其在控制病毒运输中的重要作用。

DOI：
发表时间：
2014-05
期刊：
影响因子：
0
作者：
Pitts, Jared D;Klabis, Jenifer;Richards, Alexsia L;Smith, Gregory A;Heldwein, Ekaterina E
通讯作者：
Heldwein, Ekaterina E

The Herpesvirus capsid surface protein, VP26, and the majority of the tegument proteins are dispensable for capsid transport toward the nucleus.

疱疹病毒衣壳表面蛋白 VP26 和大多数外皮蛋白对于衣壳向细胞核的运输是可有可无的。

DOI：
发表时间：
2006-06
期刊：
影响因子：
0
作者：
Antinone, Sarah E;Shubeita, George T;Coller, Kelly E;Lee, Joy I;Haverlock;Gross, Steven P;Smith, Gregory A
通讯作者：
Smith, Gregory A

Retrograde axon transport of herpes simplex virus and pseudorabies virus: a live-cell comparative analysis.

单纯疱疹病毒和伪狂犬病病毒的逆行轴突运输：活细胞比较分析。