District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32)

哥伦比亚特区 T32 神经发育障碍研究 (DC NDD T32)

• 批准号: 10647900
• 负责人: Tarik F Haydar
• 金额: $ 51.65万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-02 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647900
• 关键词: District of Columbia; Neurodevelopmental Disability; Research

Project Summary/Abstract The main objective of our T32 Training Program is to train MD and PhD post-doctoral fellows in research focused on Neurodevelopmental Disabilities (NDDs). This program, the District of Columbia NDD T32, is associated with and fully integrated into our District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC). The rationale for this program is as follows: 1) Neurodevelopmental disabilities affect a significant percentage of the US population, and 10% of households live with an individual with an NDD, therefore these conditions represent a substantial financial and emotional burden in our society; 2) The biological causes of NDDs range from genetic to acquired insults, requiring an interdisciplinary neuroscience approach to define underlying causes and mechanisms of disease; and 3) There is significant overlap of symptoms amongst the various neurodevelopmental disorders, suggesting overlapping mechanisms. Our trainees and mentors use cutting-edge techniques, including genetic, cellular/molecular, physiological, functional/behavioral, and structural/dynamic imaging to engage in basic and translational NDD research projects. Multidisciplinary training is emphasized, based on the variety of training opportunities and core facilities available at the participating institutions. Children’s National Hospital (CNH) is particularly well positioned to lead this program, based on: 1) Strengths in basic, translational and clinical research, and in mentorship in all the proposed areas of NDD research; 2) Substantial institutional resources for research and training in NDDs; 3) Established, strong collaborations with all participating institutions; and 4) Its leading role in the DC-IDDRC and in many NIH awards focusing on conditions causing NDDs. Thirty mentors from CNH, George Washington, Howard and Georgetown Universities will be involved in the program to help develop and support careers of the trainees, including submission of a K Award application. We request funding for 3 postdoctoral fellows/year who participate in a 3- year program. The trainees will obtain: 1) specific and integrated training in NDDs and 2) formal and practical training in basic and essential skills required for independence, with a focus on research methodology, statistics, and rigor and reproducibility. The training components include a core curriculum consisting of: 1) Subject matter expertise; 2) Research and quantitative skills, and 3) Communication and writing skills. In addition, trainees will have customized and experiential components to deepen their training. These include a cross-training rotation for trainees (e.g., preclinical researchers rotate in the clinic and vice versa); a regular discussion group with a world-renowned leader and author in the field of NDDs (Mark Batshaw, MD); and we also offer trainees opportunities to participate in activities that are critical for broadening their perspective on how to conduct research by interacting with the community they are aiming to help in different venues beyond the lab or clinic, which will enhance relationships and promote advocacy for the NDD community.

项目概要/摘要 我们的 T32 培训计划的主要目标是培训 MD 和 Ph.D 博士后研究员 神经发育障碍 (NDD) 该计划（哥伦比亚特区 NDD T32）与相关。 并完全融入我们的哥伦比亚特区智力和发育障碍研究中心 (DC-IDDRC) 该计划的基本原理如下： 1) 神经发育障碍影响显着。 占美国人口的百分比，并且 10% 的家庭与患有 NDD 的人住在一起，因此这些 这些状况给我们的社会带来了巨大的经济和情感负担；2) 生物学原因 NDD 的范围从遗传性到后天性损伤，需要采用跨学科的神经科学方法来定义 疾病的根本原因和机制；以及 3) 症状之间存在显着重叠 各种神经发育障碍，表明我们的学员和导师使用重叠的机制。 尖端技术，包括遗传、细胞/分子、生理、功能/行为和 结构/动态成像参与基础和转化 NDD 研究项目。 强调的是，基于参与培训机会和核心设施的多样性 国家儿童医院 (CNH) 特别适合领导该项目，因为：1) 基础、转化和临床研究以及 NDD 所有拟议领域的指导方面的优势 研究；2) 用于 NDD 研究和培训的大量机构资源；3) 成熟、强大； 与所有参与机构的合作；以及 4) 在 DC-IDDRC 和许多 NIH 奖项中的领导作用 来自 CNH、乔治·华盛顿、霍华德和乔治敦大学的 30 名导师专注于导致 NDD 的条件。 大学将参与该计划，以帮助发展和支持学员的职业生涯，包括 提交 K 奖申请，我们要求每年资助 3 名参加 3- 项目的博士后研究员。 年计划。学员将获得：1）NDD 方面的具体和综合培训；2）正式和实践。 独立所需的基本技能培训，重点是研究方法、统计、 培训内容包括核心课程，包括： 1) 主题内容。 专业知识；2) 研究和定量技能，以及 3) 沟通和写作技能。 有定制和体验式的组件来加深他们的培训，其中包括交叉培训轮换。 对于实习生（例如，临床前研究人员在诊所轮流，反之亦然）； NDD 领域的世界知名领导者和作家（Mark Ba​​tshaw，医学博士）；我们还提供实习生； 参与活动的机会对于拓宽他们对如何开展工作的看法至关重要 通过与社区互动进行研究，他们希望在实验室或诊所之外的不同场所提供帮助， 这将加强 NDD 社区的关系并促进其宣传。

项目成果

The autism spectrum among transgender youth: default mode functional connectivity.

跨性别青年中的自闭症谱系：默认模式功能连接。

• 发表时间: 2023-05-24
• 作者: Strang, John F;McClellan, Lucy S;Li, Sufang;Jack, Allison E;Wallace, Gregory L;McQuaid, Goldie A;Kenworthy, Lauren;Anthony, Laura G;Lai, Meng;Pelphrey, Kevin A;Thalberg, Alexandra E;Nelson, Eric E;Phan, Jenny M;Sadikova, Eleonora;Fisch
• 通讯作者: Fisch

Comparison of psychosocial screeners in an epilepsy clinic.

癫痫诊所心理社会筛查仪的比较。

• 发表时间: 2023-11
• 作者: Sarlo, Gabrielle L;Haughton, Taylor;Rizakos, Eleni;Merwin, Stephanie;Havens, Kathryn A;Pasupuleti, Archana;Gaillard, William D;Berl, Madison M
• 通讯作者: Berl, Madison M