CLINICAL DISCOVERY CORE

临床发现核心

• 批准号: 7923746
• 负责人: David W Haas
• 金额: $ 61.14万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7923746
• 关键词: AIDS neuropathy; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Archives; Caring; Clinical; Clinical Research; Collaborations; Color; Communities; Data; Databases; Discipline; Education; Epidemiologic Studies; Epidemiology; Fostering; Gender; Genomics; Goals; HIV; Human; Infection; Interdisciplinary Study; International; Mission; Outcome; Outcomes Research; Pathogenesis; Positioning Attribute; Prevention; Research; Research Infrastructure; Research Personnel; Research Training; Specimen; Structure; Targeted Research; Training; bench to bedside; clinical care; clinical epidemiology; cohort; human DNA; human subject; improved; multidisciplinary; patient population; programs; repository; working group

The Vanderbilt-Meharry community benefits from strong programs in HIV/AIDS clinical care, research, and training. Particular strengths include access to a large, diverse patient population through established clinical research and outcomes research infrastructures, electronic databases and specimen archives for translational and outcomes research, accomplished outcomes and epidemiology programs suitable for studying HIV/AIDS, established HIV/AIDS clinical research programs, strength in human genomics relevant to HIV, and recent recruitment to Vanderbilt and Meharry of many accomplished HIV investigators who will expand the scope and impact of HIV research. A clear focus of the Clinical Discovery Core (CDC) is to foster multidisciplinary, high-impact translational and epidemiology/outcomes HIV research at Vanderbilt and Meharry. The CDC will build upon existing strengths to continue developing a program in HIV outcomes research, with an emphasis on training new investigators, collaborations with established investigators, and the study of racial and gender disparities. A long-term goal is to improve HIV clinical research and training capacity at Meharry, which includes its historic mission of training people of color to serve the under-served via care, education, and research. The two primary components of the CDC are The Epidemiology and Outcomes Unit and The Targeted Research Cohorts Unit. With this structure the CDC is ideally positioned to foster research that spans the continuum from bench to bedside to community. The CDC will focus particular effort in three special scientific programs that have great potential for high impact and multidisciplinary collaboration: 1) International HIV/AIDS Research; 2) Human Genomics Relevant to HIV/AIDS, and 3) Research in NeuroAIDS. These scientific programs, as well as other CDC activities, will be operationalized through dynamic, task-oriented working groups. The CDC will greatly accelerate the pace of discovery by all disciplines focused on HIV/AIDS in the Vanderbilt-Meharry community, and will ultimately improve understanding regarding pathogenesis, prevention, and treatment of this devastating infection.

Vanderbilt-Meharry社区受益于HIV/AIDS临床护理，研究和 训练。特定的优势包括通过既定的临床进入大型，多样化的患者人群 研究和结果研究基础架构，电子数据库和标本档案 转化和结果研究，成就的结果和流行病学计划适合 研究艾滋病毒/艾滋病，建立的艾滋病毒/艾滋病临床研究计划，人类基因组学的力量相关 给艾滋病毒，最近招募了许多成熟的艾滋病毒调查人员的范德比尔特和梅哈里 扩大艾滋病毒研究的范围和影响。临床发现核心（CDC）的明确重点是促进 范德比尔特和 梅哈里。疾病预防控制中心将基于现有的优势，以继续制定艾滋病毒结果计划 研究重点是培训新的研究人员，与既定研究者的合作以及 种族和性别差异的研究。一个长期目标是改善HIV临床研究和培训 梅哈里（Meharry）的能力，其中包括其历史使命，该任务是培训有色人种的人，以服务不足 通过护理，教育和研究。 CDC的两个主要组成部分是流行病学和 结果单位和目标研究队列单位。使用此结构，疾病预防控制中心是 促进了从长凳到床边再到社区的连续体的研究。疾病预防控制中心将特别关注 在三个特殊的科学计划中的努力，这些计划具有巨大的影响和多学科的潜力 合作：1）国际艾滋病毒/艾滋病研究； 2）与艾滋病毒/艾滋病有关的人类基因组学和3） 神经辅助研究。这些科学计划以及其他CDC活动将被运营 通过动态，面向任务的工作组。疾病预防控制中心将大大加速所有人的发现速度 学科专注于范德比尔特·梅哈里（Vanderbilt-Meharry）社区的艾滋病毒/艾滋病，并最终将改善 了解这种毁灭性感染的发病机理，预防和治疗。