Institutional Clinical and Translational Science Award

机构临床和转化科学奖

• 批准号: 10646280
• 负责人: GARRET A FITZGERALD
• 金额: $ 1024.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646280
• 关键词: Adult; Biological Models; Cells; Childhood; Clinical Sciences; Clinical and Translational Science Awards; Democracy; Discipline; Disease; Education; Fostering; Funding; Growth; Home; Human; Institution; Persons; Phenotype; Physiology; Research; Research Personnel; Resources; Science; Translational Research; clinical implementation; drug action; novel; programs; recruit; translational medicine; translational therapeutics

OVERALL ABSTRACT/SUMMARY The Institute for Translational Medicine and Therapeutics is the academic home for the CTSA in Penn. For the past decade and a half the objectives of ITMAT have been and remain (i) to increase the number of investigators capable of pursuing their research between proof of concept in cells and model systems and (ii) elucidation of the mechanisms of human physiology, disease or drug action through intense phenotyping in small numbers of people. The two priorities of our CTSA are to foster the field of translational therapeutics and to bridge the pediatric to adult divide across the entire spectrum of clinical and translational science. This section describes how these priorities have influenced the growth of this CTSA Hub and outlines our plans for the coming funding period.

全面的 摘要/总结 转化医学和治疗研究所是 CTSA 的学术所在地 佩恩。在过去的十五年里，ITMAT 的目标一直是并且仍然是 (i) 增加能够在证明之间进行研究的调查人员数量 细胞和模型系统中的概念以及（ii）阐明人类生理学机制， 通过对少数人进行强烈的表型分析来确定疾病或药物作用。两人 我们的 CTSA 的首要任务是培育转化疗法领域并弥合 从儿科到成人的划分跨越了整个临床和转化科学领域。这 部分描述了这些优先事项如何影响该 CTSA 中心的发展并概述 我们对未来资助期的计划。

项目成果

Longitudinal Validation of the Diastolic to Systolic Time-Velocity Integral Ratio as a Doppler-Derived Measure of Pulmonary Regurgitation in Patients with Repaired Tetralogy of Fallot.

舒张期与收缩期时间-速度积分比的纵向验证作为法洛四联症修复患者肺动脉瓣反流的多普勒衍生测量。

• 发表时间: 2017-02
• 影响因子: 1.6
• 作者: Bhat, Misha;Goldmuntz, Elizabeth;Fogel, Mark A;Rychik, Jack;Mercer
• 通讯作者: Mercer

Associations of Conventional Echocardiographic Measures with Incident Heart Failure and Mortality: The Chronic Renal Insufficiency Cohort.

传统超声心动图测量与心力衰竭和死亡率的关联：慢性肾功能不全队列。

• 发表时间: 2017-01-06
• 作者: Dubin, Ruth F;Deo, Rajat;Bansal, Nisha;Anderson, Amanda H;Yang, Peter;Go, Alan S;Keane, Martin;Townsend, Ray;Porter, Anna;Budoff, Matthew;Malik, Shaista;He, Jiang;Rahman, Mahboob;Wright, Jackson;Cappola, Thomas;Kallem, Radhakrishna;Roy, Ja
• 通讯作者: Roy, Ja

Preclinical models of radiation-induced cardiac toxicity: Potential mechanisms and biomarkers.

辐射引起的心脏毒性的临床前模型：潜在机制和生物标志物。

• 发表时间: 2022
• 作者: Dreyfuss, Alexandra D;Velalopoulou, Anastasia;Avgousti, Harris;Bell, Brett I;Verginadis, Ioannis I
• 通讯作者: Verginadis, Ioannis I

The Circadian Biology of Heart Failure.

心力衰竭的昼夜节律生物学。

• 发表时间: 2023-01-20
• 影响因子: 20.1
• 作者: El Jamal, Nadim;Lordan, Ronan;Teegarden, Sarah L;Grosser, Tilo;FitzGerald, Garret
• 通讯作者: FitzGerald, Garret

Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs.

非甾体抗炎药对严重急性呼吸综合征冠状病毒2疫苗接种的免疫反应的调节。

• 发表时间: 2023-08
• 作者: Skarke, Carsten;Lordan, Ronan;Barekat, Kayla;Naik, Amruta;Mathew, Divij;Ohtani, Takuya;Greenplate, Allison R;Grant, Gregory R;Lahens, Nicholas F;Gouma, Sigrid;Troisi, Elizabeth;Sengupta, Arjun;Weljie, Aalim M;Meng, Wenzhao;Luning Prak, Eline
• 通讯作者: Luning Prak, Eline