South Carolina Cancer Disparities Research Center (SC CADRE)

南卡罗来纳州癌症差异研究中心 (SC CADRE)

• 批准号: 10650982
• 负责人: Marvella Elizabeth Ford
• 金额: $ 58.36万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10650982
• 关键词: Advanced Glycosylation End Products; Biometry; Cancer Center; Clinical Trials; Communities; Dissemination and Implementation; Evaluation; Faculty; Generations; Goals; Grant; Health; Historically Black Colleges and Universities; Institution; Island; Joints; Malignant Neoplasms; Malignant neoplasm of prostate; Medical; Medical center; Methods; Molecular; National Cancer Institute; Obesity; Outcome; Population; Recommendation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Resource Sharing; Sea; South Carolina; Structure; United States National Institutes of Health; Universities; anticancer research; biobank; cancer health disparity; community engagement; design; education research; inter-institutional; malignant breast neoplasm; novel marker; translational cancer research; undergraduate student

SUMMARY This five-year U54 proposal is a collaborative, inter-institutional partnership between South Carolina State University (SCSU), an Historically Black University (HBCU), and the Medical University of South Carolina Hollings Cancer Center (MUSC-HCC), a National Cancer Institute-designated cancer center. The partnership began in 2011 under the auspices of an NCI P20 CPACHE grant and has grown to produce this U54 South Carolina Cancer Disparities Research Center (SC CADRE) application. With input from their joint community partner, the Regional Medical Center of Orangeburg Mabry Cancer Center (RMC-MCC), investigators at both institutions collaborated to design the SC CADRE. The overarching goals of the SC CADRE are to increase SCSU's capacity to conduct transdisciplinary cancer research and to further strengthen and extend a longitudinal research education pipeline that will catalyze a new diverse generation of biomedical researchers focused on cancer disparities. The SC CADRE has three major themes. The first focuses on evaluating the relationship between obesity and prostate and breast cancer disparities. The second theme emphasizes evaluation of advanced glycation endproducts (AGEs) as a novel biomarker related to cancer, cancer disparities, and obesity. The third theme highlights the inclusion of a population unique to the US southeastern coastal region, the Sea Island (SI)/Gullah population. Within five years, the SC CADRE aims for: 1) further elucidation of molecular mechanisms contributing to cancer disparities; 2) an enhanced pipeline of diverse cancer researchers; 3) an increased number of NIH research proposals led by SCSU faculty as independent investigators; and 4) greater community engagement in cancer research. Due to the longstanding SCSU /MUSC-HCC academic partnership and each entity's research and educational strengths and community relationships, the SC CADRE is poised to transform cancer health outcomes for South Carolinians.

概括 这项为期五年的 U54 提案是南卡罗来纳州之间的一项协作性机构间伙伴关系 大学 (SCSU)、历史悠久的黑人大学 (HBCU) 和南卡罗来纳医科大学 霍林斯癌症中心 (MUSC-HCC)，国家癌症研究所指定的癌症中心。合作伙伴关系 于 2011 年在 NCI P20 CPACHE 资助下开始，现已发展到生产这款 U54 South 卡罗莱纳州癌症差异研究中心 (SC CADRE) 申请。根据他们的联合社区的意见 合作伙伴，奥兰治堡马布里癌症中心区域医疗中心 (RMC-MCC)，两家公司的研究人员 各机构合作设计了 SC CADRE。 SC CADRE 的总体目标是增加 SCSU 进行跨学科癌症研究并进一步加强和扩展癌症研究的能力 纵向研究教育渠道将促进新一代多样化的生物医学研究人员 重点关注癌症差异。 SC 干部有三大主题。第一个重点是评估 肥胖与前列腺癌和乳腺癌之间的关系差异。第二个主题强调 评估晚期糖基化终产物（AGE）作为与癌症、癌症相关的新型生物标志物 差异和肥胖。第三个主题强调包含美国东南部特有的人口 沿海地区，海岛 (SI)/Gullah 人口。五年内，SC CADRE 的目标是：1) 进一步 阐明导致癌症差异的分子机制； 2）丰富的多元化渠道 癌症研究人员； 3) 由 SCSU 教师作为独立领导领导的 NIH 研究提案数量增加 调查员； 4) 社区更多地参与癌症研究。由于 SCSU 历史悠久 /MUSC-HCC 学术合作伙伴关系以及每个实体的研究和教育优势以及社区 SC CADRE 有望改变南卡罗来纳州居民的癌症健康结果。