Biomarkers of Kaposi sarcoma recrudescence in Zambia

赞比亚卡波西肉瘤复发的生物标志物

基本信息

批准号：
10649926
负责人：
Owen Ngalamika
金额：
$ 10万
依托单位：
UNIVERSITY OF ZAMBIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-16 至 2024-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10649926
关键词：
AIDS related cancer AIDS/HIV problem Affect African Age Age-Years Area Asia Biological Markers CD4 Positive T Lymphocytes CD8-Positive T-Lymphocytes Cancer Patient Chronic Clinical Country Developed Countries Developing Countries Development Disease Elderly Environment Ethics Etiology Functional disorder Goals HIV HIV Infections HIV Seronegativity HPV-High Risk Histologic Histopathologic Grade Human Human Papillomavirus Human papilloma virus infection Hygiene Immune Immune System Diseases Immune response Immunohistochemistry Immunologic Markers Immunologic Surveillance Immunophenotyping Impairment Incidence Individual Infection Inflammaging Inflammatory Kaposi Sarcoma Lead Lesion Malignant Neoplasms Malignant neoplasm of penis Mentors Mentorship Outcome Participant Patients Penile Neoplasms Persons Phimosis Play Prevalence Recrudescences Research Design Research Personnel Risk Role Sexually Transmitted Diseases Site Skin Tissue Smoking South America Standardization Subgroup T memory cell T-Cell Depletion Teaching Hospitals Training Trauma Tumor-Infiltrating Lymphocytes Universities Urologist Viral Load result Zambia antiretroviral therapy co-infection exhaustion immune reconstitution immunosenescence improved laboratory experiment male men mortality penis premature prevent programmed cell death ligand 1 programmed cell death protein 1 recruit responsible research conduct sexually active sociodemographics tumor tumor progression

项目摘要

PROJECT SUMMARY/ABSTRACT The “Role of Human papiloma vírus and HIV in Penile Cancer Progression” study will investigate the association between presence of human papilloma virus (HPV) in penile cancer tumors and HIV co-infection with stage at presentation of penile cancer. Penile cancer is an aggressive malignancy that develops in the skin and tissues of the penis. The etiology of penile cancer is not completely understood. However, several factors including infections (HIV, Human Papillomavirus (HPV), other sexually transmitted infections), poor hygiene, advanced age, smoking, trauma, and inflammatory conditions have been associated with penile cancer development. In our setting, penile cancer patients present at a much younger age, and mostly among HIV infected individuals, than in developed countries. Even though HPV is associated with penile cancer, the presence of HPV in penile cancer ranges from 20-80%. Despite HPV being thought to play a role in penile cancer development, some studies have found that the presence of high-risk HPV in penile tumors is associated with a better outcome. The main objective of this study is to investigate the role of HPV and HIV in penile cancer progression, and to recruit and train an early investigator in the area of HIV-associated malignancies. The site for this study has a high incidence of penile cancer patients. The long-term goal of this study is to determine how the immune response can be utilized in order to limit the progression of penile cancer. Three specific aims will be accomplished: 1) Recruit, support, and mentor Dr. Victor Mapulanga to Study Penile Cancer; 2) Recruit and characterize penile cancer patients clinically, histologically, and by HPV status; and 3) Compare the presence of tumor infiltrating lymphocytes, resident memory T cells, and markers of immune exhaustion in penile tumors by HPV and HIV status. In summary, this study will investigate the role of HPV and HIV in penile cancer stage at presentation.

项目概要/摘要 “人乳头瘤病毒和艾滋病毒在阴茎癌进展中的作用”研究将调查阴茎癌肿瘤中人乳头瘤病毒 (HPV) 的存在与 HIV 合并感染之间的关联阴茎癌是一种侵袭性恶性肿瘤，发生于阴茎癌。阴茎癌的病因尚不完全清楚。因素包括感染（HIV、人乳头瘤病毒 (HPV)、其他性传播感染）、不良卫生、高龄、吸烟、创伤和炎症与阴茎有关在我们的环境中，阴茎癌患者的发病年龄要小得多，而且大多数是男性。尽管 HPV 与阴茎癌相关，但 HIV 感染者的数量仍高于发达国家。尽管 HPV 被认为在阴茎癌中发挥着重要作用，但阴茎癌中 HPV 的存在率仍为 20-80%。一些研究发现，阴茎肿瘤中存在高危型HPV，与癌症的发展有关。本研究的主要目的是调查 HPV 和 HIV 在疾病中的作用。阴茎癌进展，并招募和培训艾滋病毒相关领域的早期研究人员这项研究的目标是阴茎癌患者的高发病率。研究的目的是确定如何利用免疫反应来限制阴茎的进展将实现三个具体目标：1) 招募、支持和指导 Victor Mapulanga 博士研究阴茎癌；2) 招募阴茎癌患者并通过临床、组织学和 HPV 进行表征状态；3) 比较肿瘤浸润淋巴细胞、常驻记忆 T 细胞和标记物的存在情况 HPV 和 HIV 状态对阴茎肿瘤免疫衰竭的影响总之，本研究将探讨其作用。目前阴茎癌阶段的 HPV 和 HIV 检测。