Impacts of nicotinamide riboside on functional capacity and muscle physiology in older Veterans

烟酰胺核苷对老年退伍军人功能能力和肌肉生理学的影响

• 批准号: 10642830
• 负责人: KENNETH LADD SELDEEN
• 金额: --
• 依托单位: KANSAS CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642830
• 关键词: Activities of Daily Living; Affect; Age; Age Years; Aging; Animals; Area; Biomass; Biopsy; Cardiovascular system; Cell Respiration; Cell physiology; Clinical; Clinical Trials; Cognition; Communities; Coupled; Data; Dementia; Double-Blind Method; Elderly; Exclusion; Exercise; Exhibits; Female; Fiber; Funding; Gait speed; Genus Hippocampus; Goals; Hand Strength; Health; Healthcare; Histologic; Histology; Hospitalization; Human; Impairment; Individual; Intramuscular; Link; Mediator; Messenger RNA; Mission; Mitochondria; Morphology; Mus; Muscle; Muscle Fibers; Muscle Mitochondria; Muscle function; Muscular Atrophy; Musculoskeletal; NADH; Nicotinamide adenine dinucleotide; Nutritional; Oxygen; Participant; Pathway Analysis; Performance; Persons; Physical Function; Physical Performance; Physical activity; Physiological; Placebos; Publishing; Publishing Peer Reviews; Quality of life; Randomized, Controlled Trials; Reporting; Research; Research Design; Resources; Risk; Safety; Serum; Signal Pathway; Signal Transduction; Skeletal Muscle; Supplementation; Syndrome; Telephone; Testing; Therapeutic; Time; VO2max; Veterans; Walking; Western Blotting; Woman; Work; actigraphy; aging population; biceps brachii muscle; cofactor; comorbidity; cost; differential expression; disability risk; extracellular; fall risk; frailty; health care service utilization; healthspan; human very old age (85+); improved; innovation; insight; men; mortality; muscle form; muscle physiology; muscle strength; muscular structure; nicotinamide riboside supplementation; nicotinamide-beta-riboside; novel; preclinical study; quadriceps muscle; recruit; resilience; response; restoration; sarcopenia; sex; stressor; study population; transcriptome sequencing; treadmill; uptake; vastus lateralis

Impacts of nicotinamide riboside on functional capacity and muscle physiology in older veterans Frailty is increasingly seen within the aging population and is driven largely by musculoskeletal declines. Nearly 9 million veterans are now 65 years of age or older with impairments in functional capacity, reduction in quality of life, and an increase in the use of health care services and associated costs. An estimated 45-50% of those over the age of 85 are frail, which could represent well over 1 million veterans. Aging, which significantly contributes to frailty, is highly correlated with reduced levels of nicotinamide adenine dinucleotide (NAD+), an essential mediator in mitochondrial function. Restoration of cellular NAD+ levels is gaining support as a therapeutic strategy to maintain and even enhance functional capacity during aging. Nicotinamide riboside (NR) - an NAD+ precursor - enhances physical activity and mitochondrial health in mice. Furthermore, NR was recently shown to be safe in human clinical trials for boosting NAD+, yet the benefits for human physical performance and muscle physiology are unknown. Therefore, the goal of this project is to establish a double-blind randomized control trial to assess the impacts of NR on functional capacity, muscle function and structure, and mRNA signaling in healthy older adults. Towards this goal, this study will investigate healthy older individuals between the ages of 65-85 who will receive NR or a placebo for a period of 3 months. Participants will be tested for frailty, gait speed, and muscle strength at each time point. Additionally, muscle biopsies and serum will be collected to assess changes in muscle fiber histology, mitochondrial biomass and activity, and mRNA profiles. This project will provide greater insight into NR supplementation as a therapeutic strategy to stave off frailty and maintain resilience during aging. HIIT enhances physical performance and reduces frailty during aging.

烟酰胺核苷对老年退伍军人功能能力和肌肉生理学的影响 在老龄化过程中，衰弱现象越来越明显 人口减少，主要是由肌肉骨骼衰退造成的。 目前有近 900 万退伍军人年龄在 65 岁或以上 功能能力受损，质量下降 生活的改善，以及医疗保健服务和医疗服务的使用的增加 相关费用。据估计，45-50%的人年龄超过 85 人身体虚弱，这可能代表超过 100 万人 退伍军人。衰老会导致身体虚弱， 与烟酰胺水平降低高度相关 腺嘌呤二核苷酸 (NAD+)，一种重要的介质 线粒体功能。细胞 NAD+ 水平的恢复是 获得支持作为维持和治疗的治疗策略 甚至增强衰老过程中的功能能力。烟酰胺 核苷 (NR) - 一种 NAD+ 前体 - 增强体力 小鼠的活性和线粒体健康。此外，NR 最近在人体临床试验中被证明是安全的 促进 NAD+，但对人体表现和肌肉生理学的好处是 未知。因此，本项目的目标是建立一项双盲随机对照试验 评估 NR 对功能能力、肌肉功能和结构以及 mRNA 信号传导的影响 健康的老年人。为了实现这一目标，本研究将调查健康的老年人 65-85岁的人将接受为期3个月的NR或安慰剂。参与者将接受测试 每个时间点的虚弱程度、步态速度和肌肉力量。此外，肌肉活检和血清 将收集以评估肌纤维组织学、线粒体生物量和活性的变化，以及 mRNA 概况。该项目将更深入地了解 NR 补充剂作为一种治疗方法 在衰老过程中避免虚弱并保持弹性的策略。 HIIT 增强身体表现 并减少衰老过程中的虚弱。