CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME

核心 2 DB1：中心体的降解组学

• 批准号: 7725958
• 负责人: Alex Y Strongin
• 金额: $ 7.71万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725958
• 关键词: Automobile Driving; Biological; Centrosome; Chromatids; Chromosomal Duplication; Computer Retrieval of Information on Scientific Projects Database; Cysteine Protease; Endopeptidases; Funding; Grant; Institution; Life; MMP14 gene; Mitosis; Pathway interactions; Peptide Hydrolases; Proteolysis; Research; Research Personnel; Resources; Sister Chromatid; Source; Thinking; United States National Institutes of Health; human MMP14 protein; separase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 驱动生物学项目1：一种调节染色单体分离的蛋白水解途径。 有丝分裂期间的染色体复制和分离对于所有生命都是至关重要的。分离 姐妹染色单体被认为是由半胱氨酸蛋白酶（称为分离酶）控制的。但是我们的 初步结果表明，至少涉及其他蛋白酶，MT1-MMP。我们将 研究以下假设，即蛋白水解的协调级联反应参与染色单体 有丝分裂的分离。