CORE 2 DB1: DEGRADOMICS OF THE CENTROSOME

核心 2 DB1：中心体的降解组学

• 批准号: 7725958
• 负责人: Alex Y Strongin
• 金额: $ 7.71万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725958
• 关键词: Automobile Driving; Biological; Centrosome; Chromatids; Chromosomal Duplication; Computer Retrieval of Information on Scientific Projects Database; Cysteine Protease; Endopeptidases; Funding; Grant; Institution; Life; MMP14 gene; Mitosis; Pathway interactions; Peptide Hydrolases; Proteolysis; Research; Research Personnel; Resources; Sister Chromatid; Source; Thinking; United States National Institutes of Health; human MMP14 protein; separase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Driving Biological Project 1: A Proteolytic Pathway that Regulates Chromatid Separation. Chromosomal duplication and separation during mitosis is central to all of life. The separation of sister chromatids is thought to be controlled by a cysteine protease, called separase. Yet our preliminary results indicate that at least one other protease is involved, MT1-MMP. We will investigate the hypothesis that a coordinated cascade of proteolysis is involved in chromatid separation during mitosis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 推动生物项目 1：调节染色单体分离的蛋白水解途径。 有丝分裂期间的染色体复制和分离对于所有生命都至关重要。的分离 姐妹染色单体被认为是由一种称为分离酶的半胱氨酸蛋白酶控制的。然而我们的 初步结果表明至少还涉及另一种蛋白酶：MT1-MMP。我们将 研究染色单体涉及蛋白水解的协调级联的假设 有丝分裂期间的分离。