CORE 1 TRP4:THE PROTEOLYSIS MAP (PMAP)

核心 1 TRP4：蛋白水解图谱 (PMAP)

• 批准号: 7725957
• 负责人: Adam Godzik
• 金额: $ 20.57万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725957
• 关键词: Biological; Computer Retrieval of Information on Scientific Projects Database; Computing Methodologies; Data Set; Endopeptidases; Funding; Gene Expression Profiling; Grant; Institution; Learning; Maps; Pathway interactions; Pattern; Peptide Hydrolases; Pharmaceutical Preparations; Proteolysis; Proteome; Proteomics; Reporting; Research; Research Personnel; Research Project Grants; Resources; Scientist; Source; Stimulus; Substrate Specificity; United States National Institutes of Health; base; research study; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Technical Research Project 4, The Proteolysis Map (PMAP), will apply computational methods to develop an all-encompassing computational map of proteolytic networks. The Proteolysis Map will aid scientists in reasoning through the data sets by allowing one to computationally interrogate the effects of biological stimuli, drug inhibition, or pathophysiologic perturbations on proteolytic pathways. The Proteolysis Map will be created through an iterative learning-based approach, populated with information on i) the three dimensional structure of proteases, ii) their substrate specificity ii) results of degradomic experiments in whole proteomes, iv) all potential co-expression and/or co-localization patterns reported from gene expression profiling and from other proteomic studies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 技术研究项目4，蛋白水解图（PMAP）将应用计算方法 开发蛋白水解网络的无所不能的计算图。蛋白水解图将有助于 科学家通过允许一个人来计算询问该数据集的推理 生物刺激，药物抑制或病理生理性扰动对蛋白水解的影响 途径。蛋白水解图将通过基于迭代学习的方法创建 填充有关i）蛋白酶的三维结构的信息，ii）它们的底物 特异性ii）整个蛋白质组中降解实验的结果，iv）所有潜在的共表达 和/或来自基因表达分析和其他蛋白质组学研究的共定位模式。