The Influence of Fitness on Brain and cognition

健身对大脑和认知的影响

• 批准号: 7557819
• 负责人: MARITZA ALVARADO
• 金额: $ 4.05万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7557819
• 关键词: Adult; Aerobic; Animal Experimentation; Brain; Brain region; C-reactive protein; Cognition; Cognitive; Diffusion Magnetic Resonance Imaging; Elderly; Epidemiology; Event; Exercise; Fellowship; Functional Magnetic Resonance Imaging; Gray unit of radiation dose; Growth Factor; Human; Imaging Techniques; Individual; Insulin-Like Growth Factor I; Interleukin-6; Intervention; Laboratories; Lead; Longevity; Measures; Medial; Motor Cortex; Names; Nature; Parietal; Pattern; Performance; Process; Public Health; Research; Research Proposals; Sensory; Structure; Testing; Training; age effect; aging brain; aging population; base; cognitive function; executive function; fitness; frontal lobe; improved; inflammatory marker; memory process; neural circuit; white matter

DESCRIPTION (provided by applicant): In order to reduce the decline in cognitive abilities in the aging population, this proposal will examine the effect of aerobic fitness training on human cognition, brain structure, and the brain function of older adults. The main specific aims of this proposal include: 1) To test the hypothesis that improvements in aerobic fitness of older adults will lead to improved performance on a variety of cognitive processes, especially those supported by the frontal regions of the brain, 2) To test the hypothesis that the improvements in cognitive processes engendered by enhanced aerobic fitness will be supported by changes in underlying neural circuits, as inferred from patterns of fMRI activation, 3) To test the hypothesis that improvements in aerobic fitness, over the course of a 1 year intervention, will result in increases in gray and white matter volume in regions of the human brain (i.e. primarily frontal, medial temporal and parietal regions), 4) To test the hypothesis that increased levels of insulin-like growth factor 1 (IGF1) and decreases in markers of inflammation (i.e. C-reactive protein and interleukin-6) engendered by improvements in aerobic fitness will moderate the fitness benefits observed on measures of cognition, brain function and structure.

描述（由申请人提供）：为了降低人口老龄化的认知能力下降，该提案将研究有氧健身训练对人类认知，大脑结构和老年人大脑功能的影响。该提案的主要特定目的包括：1）测试以下假设：老年人的有氧健身能力的改善将在各种认知过程中提高性能，尤其是那些受到大脑额叶区域支持的认知过程的表现，2）测试假设，即从增强的循环范围内的认知过程中的改善，而跨越了综合的循环，这是综合的，而跨越了，因为有机化的循环范围会变化。 activation, 3) To test the hypothesis that improvements in aerobic fitness, over the course of a 1 year intervention, will result in increases in gray and white matter volume in regions of the human brain (i.e. primarily frontal, medial temporal and parietal regions), 4) To test the hypothesis that increased levels of insulin-like growth factor 1 (IGF1) and decreases in markers of inflammation (i.e. C-reactive protein和白介素6）由有氧健身的改善而产生的，将适应认知，脑功能和结构的措施所观察到的适应性益处。