Topographic and activity-dependent lateral inhibition

地形和活动依赖性侧向抑制

• 批准号: 7670250
• 负责人: ARMEN C AREVIAN
• 金额: $ 3.33万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7670250
• 关键词: Address; Affect; Cells; Classification; Clinical Pathology; Cognition Disorders; Effectiveness; Individual; Lateral; Location; Neurons; Odors; Output; Patch-Clamp Techniques; Pattern; Physiological; Population; Process; Property; Recruitment Activity; Relative (related person); Retina; Role; Schizophrenia; Simulate; Specific qualifier value; System; Time; base; design; extracellular; granule cell; improved; network models; olfactory bulb; postsynaptic; presynaptic; response; time interval

DESCRIPTION (provided by applicant): In this project we address key issues in the processing of olfactory information in the olfactory bulb. Specifically, we are investigating the mechanisms that could allow for specific and useful inhibitory interactions among neurons in the olfactory bulb. Our preliminary evidence suggests that the mechanism employed enables an activity-dependent form of lateral inhibition that could function to improve contrast enhancement between odor responses in a dynamic manner irrespective of the topographical organization within the bulb. This mechanism could be employed in many systems where the spatial location of neurons is not clearly related to their individual response profiles. Furthermore, a more thorough understanding of the functional role of physiologic neuronal properties such as lateral inhibition can be applied to principles governing multiple clinical pathologies such as Schizophrenia and other cognitive disorders.

描述（由申请人提供）：在这个项目中，我们解决了嗅球中嗅觉信息处理的关键问题。具体来说，我们正在研究可能允许嗅球神经元之间发生特定且有用的抑制相互作用的机制。我们的初步证据表明，所采用的机制能够实现一种活动依赖性形式的侧向抑制，可以以动态方式改善气味反应之间的对比度增强，而不管球茎内的地形组织如何。这种机制可以在许多系统中使用，其中神经元的空间位置与其各自的反应曲线没有明显的相关性。此外，对生理神经元特性（例如侧向抑制）的功能作用的更透彻理解可以应用于控制多种临床病理学（例如精神分裂症和其他认知障碍）的原理。